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Temporal Control of Mammalian Cortical Neurogenesis by m(6)A Methylation.
Yoon KJ, Ringeling FR, Vissers C, Jacob F, Pokrass M, Jimenez-Cyrus D, Su Y, Kim NS, Zhu Y, Zheng L, Kim S, Wang X, Doré LC, Jin P, Regot S, Zhuang X, Canzar S, He C, Ming GL, Song H. Yoon KJ, et al. Cell. 2017 Nov 2;171(4):877-889.e17. doi: 10.1016/j.cell.2017.09.003. Epub 2017 Sep 28. Cell. 2017. PMID: 28965759 Free PMC article.
Further analysis uncovers previously unappreciated transcriptional prepatterning in cortical neural stem cells. m(6)A signaling also regulates human cortical neurogenesis in forebrain organoids. ...Our study identifies an epitranscriptomic mechanism in height …
Further analysis uncovers previously unappreciated transcriptional prepatterning in cortical neural stem cells. m(6)A signaling also …
Ythdf2-mediated m6A mRNA clearance modulates neural development in mice.
Li M, Zhao X, Wang W, Shi H, Pan Q, Lu Z, Perez SP, Suganthan R, He C, Bjørås M, Klungland A. Li M, et al. Genome Biol. 2018 May 31;19(1):69. doi: 10.1186/s13059-018-1436-y. Genome Biol. 2018. PMID: 29855337 Free PMC article.
Most recently, it was shown that the Mettl3-Mettl14 writer complex of this mark is required for the temporal control of cortical neurogenesis. The m(6)A reader protein Ythdf2 promotes mRNA degradation by recognizing m(6)A and recruiting the mRNA decay …
Most recently, it was shown that the Mettl3-Mettl14 writer complex of this mark is required for the temporal control of cor