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Discovery of novel spirocyclic inhibitors of fatty acid amide hydrolase (FAAH). Part 1: identification of 7-azaspiro[3.5]nonane and 1-oxa-8-azaspiro[4.5]decane as lead scaffolds.
Meyers MJ, Long SA, Pelc MJ, Wang JL, Bowen SJ, Walker MC, Schweitzer BA, Madsen HM, Tenbrink RE, McDonald J, Smith SE, Foltin S, Beidler D, Thorarensen A. Meyers MJ, et al. Among authors: tenbrink re. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6538-44. doi: 10.1016/j.bmcl.2011.08.055. Epub 2011 Aug 22. Bioorg Med Chem Lett. 2011. PMID: 21924614
Thienopyrimidine-based P2Y12 platelet aggregation inhibitors.
Kortum SW, Lachance RM, Schweitzer BA, Yalamanchili G, Rahman H, Ennis MD, Huff RM, TenBrink RE. Kortum SW, et al. Among authors: tenbrink re. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5919-23. doi: 10.1016/j.bmcl.2009.08.059. Epub 2009 Aug 20. Bioorg Med Chem Lett. 2009. PMID: 19748783
Structure based design of novel irreversible FAAH inhibitors.
Wang JL, Bowen SJ, Schweitzer BA, Madsen HM, McDonald J, Pelc MJ, Tenbrink RE, Beidler D, Thorarensen A. Wang JL, et al. Among authors: tenbrink re. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5970-4. doi: 10.1016/j.bmcl.2009.07.101. Epub 2009 Jul 25. Bioorg Med Chem Lett. 2009. PMID: 19765986
Potent and selective isophthalamide S2 hydroxyethylamine inhibitors of BACE1.
Kortum SW, Benson TE, Bienkowski MJ, Emmons TL, Prince DB, Paddock DJ, Tomasselli AG, Moon JB, LaBorde A, TenBrink RE. Kortum SW, et al. Among authors: tenbrink re. Bioorg Med Chem Lett. 2007 Jun 15;17(12):3378-83. doi: 10.1016/j.bmcl.2007.03.096. Epub 2007 Apr 3. Bioorg Med Chem Lett. 2007. PMID: 17434734
Identification of N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases.
Vazquez ML, Kaila N, Strohbach JW, Trzupek JD, Brown MF, Flanagan ME, Mitton-Fry MJ, Johnson TA, TenBrink RE, Arnold EP, Basak A, Heasley SE, Kwon S, Langille J, Parikh MD, Griffin SH, Casavant JM, Duclos BA, Fenwick AE, Harris TM, Han S, Caspers N, Dowty ME, Yang X, Banker ME, Hegen M, Symanowicz PT, Li L, Wang L, Lin TH, Jussif J, Clark JD, Telliez JB, Robinson RP, Unwalla R. Vazquez ML, et al. Among authors: tenbrink re. J Med Chem. 2018 Feb 8;61(3):1130-1152. doi: 10.1021/acs.jmedchem.7b01598. Epub 2018 Jan 23. J Med Chem. 2018. PMID: 29298069
Inhibitors of the protease from human immunodeficiency virus: synthesis, enzyme inhibition, and antiviral activity of a series of compounds containing the dihydroxyethylene transition-state isostere.
Thaisrivongs S, Turner SR, Strohbach JW, TenBrink RE, Tarpley WG, McQuade TJ, Heinrikson RL, Tomasselli AG, Hui JO, Howe WJ. Thaisrivongs S, et al. Among authors: tenbrink re. J Med Chem. 1993 Apr 16;36(8):941-52. doi: 10.1021/jm00060a001. J Med Chem. 1993. PMID: 8478908
Arylformamidines with antinociceptive properties.
Gall M, McCall JM, TenBrink RE, Von Voigtlander PF, Mohrland JS. Gall M, et al. Among authors: tenbrink re. J Med Chem. 1988 Sep;31(9):1816-20. doi: 10.1021/jm00117a023. J Med Chem. 1988. PMID: 3411603
25 results