First-in-human results of terbium-161 [(161)Tb]Tb-PSMA-I&T dual beta-Auger radioligand therapy in patients with metastatic castration-resistant prostate cancer (VIOLET): a single-centre, single-arm, phase 1/2 study.
Buteau JP, Kostos L, Jackson PA, Xie J, Haskali MB, Alipour R, McIntosh LE, Emmerson B, MacFarlane L, Martin CA, Chan J, Williams SE, Jewell KE, Eifer M, Hamilton AJ, Harris WQ, Akhurst T, Au L, Cardin AJ, Furic L, Kashyap RK, Kong G, Ravi Kumar AS, Murphy DG, Ravi R, Saghebi J, Sandhu S, Tran B, Azad AA, Hofman MS.
Buteau JP, et al.
Lancet Oncol. 2025 Aug;26(8):1009-1017. doi: 10.1016/S1470-2045(25)00332-8. Epub 2025 Jul 3.
Lancet Oncol. 2025.
PMID: 40617237
Clinical Trial.
BACKGROUND: Terbium-161 ((161)Tb) emits beta-radiation similar to lutetium-177 ((177)Lu), with additional radiation over ultra-short path lengths from Auger electrons. (161)Tb has shown superior in-vitro and in-vivo efficacy compared with (177)Lu. ...
BACKGROUND: Terbium-161 ((161)Tb) emits beta-radiation similar to lutetium-177 ((177)Lu), with additional radiation over ultra …