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Lipofuscin: mechanisms of age-related accumulation and influence on cell function.
Brunk UT, Terman A. Brunk UT, et al. Among authors: terman a. Free Radic Biol Med. 2002 Sep 1;33(5):611-9. doi: 10.1016/s0891-5849(02)00959-0. Free Radic Biol Med. 2002. PMID: 12208347 Review.
The accumulation of lipofuscin within postmitotic cells is a recognized hallmark of aging occurring with a rate inversely related to longevity. ...Lipofuscin is a fluorochrome and may sensitize lysosomes to visible light, a process potentially importan …
The accumulation of lipofuscin within postmitotic cells is a recognized hallmark of aging occurring with a rate inversely rela …
Lysosomal iron, iron chelation, and cell death.
Terman A, Kurz T. Terman A, et al. Antioxid Redox Signal. 2013 Mar 10;18(8):888-98. doi: 10.1089/ars.2012.4885. Epub 2012 Oct 9. Antioxid Redox Signal. 2013. PMID: 22909065 Review.
Macroautophagy-generated increase of lysosomal amyloid β-protein mediates oxidant-induced apoptosis of cultured neuroblastoma cells.
Zheng L, Terman A, Hallbeck M, Dehvari N, Cowburn RF, Benedikz E, Kågedal K, Cedazo-Minguez A, Marcusson J. Zheng L, et al. Among authors: terman a. Autophagy. 2011 Dec;7(12):1528-45. doi: 10.4161/auto.7.12.18051. Autophagy. 2011. PMID: 22108004 Free PMC article.
Autophagy in cardiac myocyte homeostasis, aging, and pathology.
Terman A, Brunk UT. Terman A, et al. Cardiovasc Res. 2005 Dec 1;68(3):355-65. doi: 10.1016/j.cardiores.2005.08.014. Epub 2005 Oct 6. Cardiovasc Res. 2005. PMID: 16213475 Review.
Autophagy is involved in the most important cardiac pathologies including myocardial hypertrophy, cardiomyopathies, and ischemic heart disease, a fact that has led to increasing attention to this process....
Autophagy is involved in the most important cardiac pathologies including myocardial hypertrophy, cardiomyopathies, and ischemic heart disea …
Is aging the price for memory?
Terman A, Brunk UT. Terman A, et al. Biogerontology. 2005;6(3):205-10. doi: 10.1007/s10522-005-7956-3. Biogerontology. 2005. PMID: 16041624 Review.
We assume that the development of long-lived postmitotic cells, now found in the overwhelming majority of species, represented a useful evolutionary change. ...
We assume that the development of long-lived postmitotic cells, now found in the overwhelming majority of species, represented a usef …
Mitochondrial recycling and aging of cardiac myocytes: the role of autophagocytosis.
Terman A, Dalen H, Eaton JW, Neuzil J, Brunk UT. Terman A, et al. Exp Gerontol. 2003 Aug;38(8):863-76. doi: 10.1016/s0531-5565(03)00114-1. Exp Gerontol. 2003. PMID: 12915208
Mitochondrial enlargement may result from impaired fission, a possibility supported by depressed DNA synthesis in large mitochondria. ...
Mitochondrial enlargement may result from impaired fission, a possibility supported by depressed DNA synthesis in large mitochondria. …
Myocyte aging and mitochondrial turnover.
Terman A, Brunk UT. Terman A, et al. Exp Gerontol. 2004 May;39(5):701-5. doi: 10.1016/j.exger.2004.01.005. Exp Gerontol. 2004. PMID: 15130664 Review.
Mitochondrial turnover and aging of long-lived postmitotic cells: the mitochondrial-lysosomal axis theory of aging.
Terman A, Kurz T, Navratil M, Arriaga EA, Brunk UT. Terman A, et al. Antioxid Redox Signal. 2010 Apr;12(4):503-35. doi: 10.1089/ars.2009.2598. Antioxid Redox Signal. 2010. PMID: 19650712 Free PMC article. Review.
It is now generally accepted that aging and eventual death of multicellular organisms is to a large extent related to macromolecular damage by mitochondrially produced reactive oxygen species, mostly affecting long-lived postmitotic cells, such as neurons and cardiac myocy …
It is now generally accepted that aging and eventual death of multicellular organisms is to a large extent related to macromolecular …
Lipofuscin.
Terman A, Brunk UT. Terman A, et al. Int J Biochem Cell Biol. 2004 Aug;36(8):1400-4. doi: 10.1016/j.biocel.2003.08.009. Int J Biochem Cell Biol. 2004. PMID: 15147719 Review.
Over time, postmitotic cells accumulate a non-degradable intralysosomal substance, lipofuscin, which forms due to iron-catalyzed oxidation/polymerization of protein and lipid residues. Lipofuscin is often considered a hallmark of aging, showing an accumulation rate …
Over time, postmitotic cells accumulate a non-degradable intralysosomal substance, lipofuscin, which forms due to iron-catalyzed oxid …
The involvement of lysosomes in myocardial aging and disease.
Terman A, Kurz T, Gustafsson B, Brunk UT. Terman A, et al. Curr Cardiol Rev. 2008 May;4(2):107-15. doi: 10.2174/157340308784245801. Curr Cardiol Rev. 2008. PMID: 19936285 Free PMC article.
As a consequence, cardiac myocytes gradually undergo pronounced age-related alterations which, furthermore, occur at a rate that inversely correlates with the longevity of species. ...Lysosomal destabilization is of importance in the induction and/or execution of pr …
As a consequence, cardiac myocytes gradually undergo pronounced age-related alterations which, furthermore, occur at a rate th …
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