Augmentation of antitumor effects of p53 gene therapy by combination with HDAC inhibitor.
Takimoto R, Kato J, Terui T, Takada K, Kuroiwa G, Wu J, Ohnuma H, Takahari D, Kobune M, Sato Y, Takayama T, Matsunaga T, Niitsu Y.
Takimoto R, et al. Among authors: terui t.
Cancer Biol Ther. 2005 Apr;4(4):421-8. doi: 10.4161/cbt.4.4.1620. Epub 2005 Apr 21.
Cancer Biol Ther. 2005.
PMID: 15846102
We have previously shown that the HDAC inhibitors (HDACI) activate the p53 molecule through acetylation of 320 and 373 lysine residues, upregulate PIG3 and NOXA and induce apoptosis in cancer cells expressing wild and pseudo-wild type p53 genes (Terui T, et al. Canc …
We have previously shown that the HDAC inhibitors (HDACI) activate the p53 molecule through acetylation of 320 and 373 lysine residues, upre …