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Page 1
Tesofensine, a monoamine reuptake inhibitor for the treatment of obesity.
Bello NT, Zahner MR. Bello NT, et al. Curr Opin Investig Drugs. 2009 Oct;10(10):1105-16. Curr Opin Investig Drugs. 2009. PMID: 19777399 Review.
Tesofensine, a monoamine reuptake inhibitor, is under development by NeuroSearch A/S for the potential treatment of obesity. ...Overall, tesofensine was associated with minor adverse events. Tesofensine caused dose-dependent elevations in heart rate, with sig …
Tesofensine, a monoamine reuptake inhibitor, is under development by NeuroSearch A/S for the potential treatment of obesity. ...Overa …
Tesofensine, a novel antiobesity drug, silences GABAergic hypothalamic neurons.
Perez CI, Luis-Islas J, Lopez A, Diaz X, Molina O, Arroyo B, Moreno MG, Lievana EG, Fonseca E, Castañeda-Hernández G, Gutierrez R. Perez CI, et al. PLoS One. 2024 Apr 24;19(4):e0300544. doi: 10.1371/journal.pone.0300544. eCollection 2024. PLoS One. 2024. PMID: 38656972 Free PMC article.
In Vgat-ChR2 and Vgat-IRES-cre transgenic mice, we found for the first time that tesofensine inhibited a subset of LH GABAergic neurons, reducing their ability to promote feeding behavior, and chemogenetically silencing them enhanced tesofensine's food-suppressing e …
In Vgat-ChR2 and Vgat-IRES-cre transgenic mice, we found for the first time that tesofensine inhibited a subset of LH GABAergic neuro …
Tesofensine and weight loss.
Sommet A, Pathak A, Montastruc JL. Sommet A, et al. Lancet. 2009 Feb 28;373(9665):719; author reply 720. doi: 10.1016/S0140-6736(09)60433-5. Lancet. 2009. PMID: 19249626 No abstract available.
Tesofensine and weight loss.
Tsai AG. Tsai AG. Lancet. 2009 Feb 28;373(9665):719; author reply 720. doi: 10.1016/S0140-6736(09)60432-3. Lancet. 2009. PMID: 19249625 No abstract available.
Weight loss produced by tesofensine in patients with Parkinson's or Alzheimer's disease.
Astrup A, Meier DH, Mikkelsen BO, Villumsen JS, Larsen TM. Astrup A, et al. Obesity (Silver Spring). 2008 Jun;16(6):1363-9. doi: 10.1038/oby.2008.56. Epub 2008 Mar 20. Obesity (Silver Spring). 2008. PMID: 18356831 Free article.
OBJECTIVE: Tesofensine (TE) is a norepinephrine, dopamine, and serotonin reuptake inhibitor. We conducted a meta-analysis of TE's effect on body weight in trials investigating its potential for treatment of Parkinson's or Alzheimer's disease. ...
OBJECTIVE: Tesofensine (TE) is a norepinephrine, dopamine, and serotonin reuptake inhibitor. We conducted a meta-analysis of TE's eff …
Tesofensine, a novel triple monoamine reuptake inhibitor, induces appetite suppression by indirect stimulation of alpha1 adrenoceptor and dopamine D1 receptor pathways in the diet-induced obese rat.
Axel AM, Mikkelsen JD, Hansen HH. Axel AM, et al. Neuropsychopharmacology. 2010 Jun;35(7):1464-76. doi: 10.1038/npp.2010.16. Epub 2010 Mar 3. Neuropsychopharmacology. 2010. PMID: 20200509 Free PMC article.
Tesofensine is a novel monoamine reuptake inhibitor that inhibits both norepinephrine, 5-HT, and dopamine (DA) reuptake function. ...Tesofensine (0.5-3.0 mg/kg, s.c.) induced a dose-dependent and marked decline in food intake with an ED(50) of 1.3 mg/kg. ...
Tesofensine is a novel monoamine reuptake inhibitor that inhibits both norepinephrine, 5-HT, and dopamine (DA) reuptake function. ... …
Tesofensine induces appetite suppression and weight loss with reversal of low forebrain dopamine levels in the diet-induced obese rat.
Hansen HH, Jensen MM, Overgaard A, Weikop P, Mikkelsen JD. Hansen HH, et al. Pharmacol Biochem Behav. 2013 Sep;110:265-71. doi: 10.1016/j.pbb.2013.07.018. Epub 2013 Aug 7. Pharmacol Biochem Behav. 2013. PMID: 23932919
Tesofensine is a triple monoamine reuptake inhibitor which inhibits noradrenaline, 5-HT and dopamine reuptake. ...In conclusion, tesofensine produces weight loss together with reversal of lowered forebrain dopamine levels in DIO rats, suggesting that tesofensine …
Tesofensine is a triple monoamine reuptake inhibitor which inhibits noradrenaline, 5-HT and dopamine reuptake. ...In conclusion, t …
Under-reporting of adverse effects of tesofensine.
Astrup A, Madsbad S, Breum L, Jensen TJ, Kroustrup JP, Larsen TM. Astrup A, et al. Lancet. 2013 Jul 13;382(9887):127. doi: 10.1016/S0140-6736(13)61563-9. Lancet. 2013. PMID: 23849924 No abstract available.
Triple monoamine inhibitor tesofensine decreases food intake, body weight, and striatal dopamine D2/D3 receptor availability in diet-induced obese rats.
van de Giessen E, de Bruin K, la Fleur SE, van den Brink W, Booij J. van de Giessen E, et al. Eur Neuropsychopharmacol. 2012 Apr;22(4):290-9. doi: 10.1016/j.euroneuro.2011.07.015. Epub 2011 Sep 1. Eur Neuropsychopharmacol. 2012. PMID: 21889317
The novel triple monoamine inhibitor tesofensine blocks dopamine, serotonin and norepinephrine re-uptake and is a promising candidate for the treatment of obesity. ...Four groups of 15 DIO rats were randomized to one of the following treatments for 28 days: 1. tesofensi …
The novel triple monoamine inhibitor tesofensine blocks dopamine, serotonin and norepinephrine re-uptake and is a promising candidate …
55 results