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Growth-cone attraction to netrin-1 is converted to repulsion by laminin-1.
Höpker VH, Shewan D, Tessier-Lavigne M, Poo M, Holt C. Höpker VH, et al. Nature. 1999 Sep 2;401(6748):69-73. doi: 10.1038/43441. Nature. 1999. PMID: 10485706
Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells.
Qi Y, Zhang XJ, Renier N, Wu Z, Atkin T, Sun Z, Ozair MZ, Tchieu J, Zimmer B, Fattahi F, Ganat Y, Azevedo R, Zeltner N, Brivanlou AH, Karayiorgou M, Gogos J, Tomishima M, Tessier-Lavigne M, Shi SH, Studer L. Qi Y, et al. Nat Biotechnol. 2017 Feb;35(2):154-163. doi: 10.1038/nbt.3777. Epub 2017 Jan 23. Nat Biotechnol. 2017. PMID: 28112759 Free PMC article.
A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death.
Wetzel-Smith MK, Hunkapiller J, Bhangale TR, Srinivasan K, Maloney JA, Atwal JK, Sa SM, Yaylaoglu MB, Foreman O, Ortmann W, Rathore N, Hansen DV, Tessier-Lavigne M; Alzheimer's Disease Genetics Consortium, Mayeux R, Pericak-Vance M, Haines J, Farrer LA, Schellenberg GD, Goate A, Behrens TW, Cruchaga C, Watts RJ, Graham RR. Wetzel-Smith MK, et al. Nat Med. 2014 Dec;20(12):1452-7. doi: 10.1038/nm.3736. Epub 2014 Nov 24. Nat Med. 2014. PMID: 25419706 Free PMC article.
CRISPR-Cas9 screens in human cells and primary neurons identify modifiers of C9ORF72 dipeptide-repeat-protein toxicity.
Kramer NJ, Haney MS, Morgens DW, Jovičić A, Couthouis J, Li A, Ousey J, Ma R, Bieri G, Tsui CK, Shi Y, Hertz NT, Tessier-Lavigne M, Ichida JK, Bassik MC, Gitler AD. Kramer NJ, et al. Nat Genet. 2018 Apr;50(4):603-612. doi: 10.1038/s41588-018-0070-7. Epub 2018 Mar 5. Nat Genet. 2018. PMID: 29507424 Free PMC article.
Defining the ligand specificity of the deleted in colorectal cancer (DCC) receptor.
Haddick PC, Tom I, Luis E, Quiñones G, Wranik BJ, Ramani SR, Stephan JP, Tessier-Lavigne M, Gonzalez LC. Haddick PC, et al. PLoS One. 2014 Jan 6;9(1):e84823. doi: 10.1371/journal.pone.0084823. eCollection 2014. PLoS One. 2014. PMID: 24400119 Free PMC article.
APP binds DR6 to trigger axon pruning and neuron death via distinct caspases.
Nikolaev A, McLaughlin T, O'Leary DD, Tessier-Lavigne M. Nikolaev A, et al. Nature. 2009 Feb 19;457(7232):981-9. doi: 10.1038/nature07767. Nature. 2009. PMID: 19225519 Free PMC article.
Alternative splicing of the Robo3 axon guidance receptor governs the midline switch from attraction to repulsion.
Chen Z, Gore BB, Long H, Ma L, Tessier-Lavigne M. Chen Z, et al. Neuron. 2008 May 8;58(3):325-32. doi: 10.1016/j.neuron.2008.02.016. Neuron. 2008. PMID: 18466743
Recognition of the neural chemoattractant Netrin-1 by integrins alpha6beta4 and alpha3beta1 regulates epithelial cell adhesion and migration.
Yebra M, Montgomery AM, Diaferia GR, Kaido T, Silletti S, Perez B, Just ML, Hildbrand S, Hurford R, Florkiewicz E, Tessier-Lavigne M, Cirulli V. Yebra M, et al. Dev Cell. 2003 Nov;5(5):695-707. doi: 10.1016/s1534-5807(03)00330-7. Dev Cell. 2003. PMID: 14602071
Directional guidance of interneuron migration to the cerebral cortex relies on subcortical Slit1/2-independent repulsion and cortical attraction.
Marín O, Plump AS, Flames N, Sánchez-Camacho C, Tessier-Lavigne M, Rubenstein JL. Marín O, et al. Development. 2003 May;130(9):1889-901. doi: 10.1242/dev.00417. Development. 2003. PMID: 12642493
PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates.
Lu X, Borchers AG, Jolicoeur C, Rayburn H, Baker JC, Tessier-Lavigne M. Lu X, et al. Nature. 2004 Jul 1;430(6995):93-8. doi: 10.1038/nature02677. Nature. 2004. PMID: 15229603
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