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135 results

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Page 1
The Balance of Th17 versus Treg Cells in Autoimmunity.
Lee GR. Lee GR. Int J Mol Sci. 2018 Mar 3;19(3):730. doi: 10.3390/ijms19030730. Int J Mol Sci. 2018. PMID: 29510522 Free PMC article. Review.
T helper type 17 (Th17) cells and pTreg cells, which share a common precursor cell (the naive CD4 T cell), require a common tumor growth factor (TGF)-beta signal for initial differentiation. However, terminally differentiated cells fulfill opposite fun …
T helper type 17 (Th17) cells and pTreg cells, which share a common precursor cell (the naive CD4 T cell), require a co …
The Function and Role of the Th17/Treg Cell Balance in Inflammatory Bowel Disease.
Yan JB, Luo MM, Chen ZY, He BH. Yan JB, et al. J Immunol Res. 2020 Dec 15;2020:8813558. doi: 10.1155/2020/8813558. eCollection 2020. J Immunol Res. 2020. PMID: 33381606 Free PMC article. Review.
Inflammatory bowel disease (IBD) is a chronic, inflammatory, and autoimmune disorder. The pathogenesis of IBD is not yet clear. Studies have shown that the imbalance between T helper 17 (Th17) and regulatory T (Treg) cells, which differentiate from CD4 …
Inflammatory bowel disease (IBD) is a chronic, inflammatory, and autoimmune disorder. The pathogenesis of IBD is not yet clear. Studi …
Gut microbiota-derived metabolites modulate Treg/Th17 balance: novel therapeutic targets in autoimmune diseases.
Li G, Xiong Y, Li Z, Yu Q, Li S, Xie J, Zeng S, Yu D, Yang Y, Yu J. Li G, et al. Front Immunol. 2025 Nov 10;16:1710733. doi: 10.3389/fimmu.2025.1710733. eCollection 2025. Front Immunol. 2025. PMID: 41293163 Free PMC article. Review.
Dysregulation of the homeostasis between regulatory T cell (Treg) and T helper 17 cell (Th17) is increasingly recognized as a pivotal mechanism in the pathogenesis of autoimmune diseases. ...This Review synthesizes recent clinical and preclinical findings on …
Dysregulation of the homeostasis between regulatory T cell (Treg) and T helper 17 cell (Th17) is increasingly recognized as a …
Gut Microbiota as Regulators of Th17/Treg Balance in Patients With Myasthenia Gravis.
Chen P, Tang X. Chen P, et al. Front Immunol. 2021 Dec 23;12:803101. doi: 10.3389/fimmu.2021.803101. eCollection 2021. Front Immunol. 2021. PMID: 35003133 Free PMC article. Review.
Among the numerous factors influencing the balance of Th17/Treg cells, the gut microbiota have received attention from scholars. Gut microbial dysbiosis and altered microbial metabolites have been seen in patients with MG. Therefore, correcting Th17 …
Among the numerous factors influencing the balance of Th17/Treg cells, the gut microbiota have received attentio …
Notch3 destabilizes regulatory T cells to drive autoimmune neuroinflammation in multiple sclerosis.
Benamar M, Contini P, Schmitz-Abe K, Lanzetta O, Getachew F, Bachelin C, Leyva Castillo JM, Wang M, Oktelik FB, Perrot O, Batamack Y, Arbag SN, Stephen-Victor E, Harb H, Agrawal PB, Louapre C, Ivaldi F, Uccelli A, Inglese M, Angelini C, Zujovic V, De Palma R, Chatila TA. Benamar M, et al. Immunity. 2025 Nov 11;58(11):2753-2768.e6. doi: 10.1016/j.immuni.2025.09.007. Epub 2025 Oct 2. Immunity. 2025. PMID: 41043415
Notch3(+) Treg cells were induced by the gut microbiota via Toll-like receptor (TLR)-dependent mechanisms. ...Notch3 interacted with delta-like ligand 1 (DLL1) on microglia to subvert Treg cells into T helper 17 (Th17) cells. Notch …
Notch3(+) Treg cells were induced by the gut microbiota via Toll-like receptor (TLR)-dependent mechanisms. ...Notch3 in …
Microbiota-produced immune regulatory bile acid metabolites control central nervous system autoimmunity.
Antonini Cencicchio M, Montini F, Palmieri V, Massimino L, Lo Conte M, Finardi A, Mandelli A, Asnicar F, Pavlovic R, Drago D, Ungaro F, Andolfo A, Segata N, Martinelli V, Furlan R, Falcone M. Antonini Cencicchio M, et al. Cell Rep Med. 2025 Apr 15;6(4):102028. doi: 10.1016/j.xcrm.2025.102028. Epub 2025 Mar 17. Cell Rep Med. 2025. PMID: 40101713 Free PMC article.
Deoxycholic acid (DCA) and lithocholic acid (LCA) are secondary bile acid metabolites (BAMs) produced from primary bile acids by gut microbiota that play key immune regulatory functions by promoting FOXP3(+) regulatory T (Treg) cell differentiation at the expense of …
Deoxycholic acid (DCA) and lithocholic acid (LCA) are secondary bile acid metabolites (BAMs) produced from primary bile acids by gut micr …
T Cells in Fibrosis and Fibrotic Diseases.
Zhang M, Zhang S. Zhang M, et al. Front Immunol. 2020 Jun 26;11:1142. doi: 10.3389/fimmu.2020.01142. eCollection 2020. Front Immunol. 2020. PMID: 32676074 Free PMC article. Review.
Although the roles of macrophages in fibrogenesis have been studied for many years, the underlying mechanisms concerning the manner in which T cells regulate fibrosis are not completely understood. The T cell receptor (TCR) engages the antigen and shapes the repertoire of …
Although the roles of macrophages in fibrogenesis have been studied for many years, the underlying mechanisms concerning the manner in which …
Maidong Dishao Decoction mitigates submandibular gland injury in NOD mice through modulation of gut microbiota and restoration of Th17/Treg immune balance.
Zhang Y, Wu Y, Guan Y, Lu Y, Zhu W, Ping F, Wang Y. Zhang Y, et al. Heliyon. 2024 Sep 25;10(21):e38421. doi: 10.1016/j.heliyon.2024.e38421. eCollection 2024 Nov 15. Heliyon. 2024. PMID: 39524804 Free PMC article.
OBJECTIVE: This study aims to investigate the effects of MDDST on gut microbiota, short-chain fatty acids (SCFAs), and the Th17/Treg immune balance in non-obese diabetes (NOD) mice. ...CONCLUSION: In summary, MDDST demonstrates protective effects against pSS …
OBJECTIVE: This study aims to investigate the effects of MDDST on gut microbiota, short-chain fatty acids (SCFAs), and the Th17 …
Indole-3-Acetic Acid Alters Intestinal Microbiota and Alleviates Ankylosing Spondylitis in Mice.
Shen J, Yang L, You K, Chen T, Su Z, Cui Z, Wang M, Zhang W, Liu B, Zhou K, Lu H. Shen J, et al. Front Immunol. 2022 Feb 4;13:762580. doi: 10.3389/fimmu.2022.762580. eCollection 2022. Front Immunol. 2022. PMID: 35185872 Free PMC article.
The effects of IAA on AS mice were evaluated by examining disease severity, intestinal barrier function, aryl hydrocarbon receptor (AhR) pathway, T-helper 17 (Th17)/T regulatory (Treg) balance, and inflammatory cytokine levels. The intestinal microbiota compo …
The effects of IAA on AS mice were evaluated by examining disease severity, intestinal barrier function, aryl hydrocarbon receptor (AhR) pat …
Autoimmune thyroid diseases and Th17/Treg lymphocytes.
Shao S, Yu X, Shen L. Shao S, et al. Life Sci. 2018 Jan 1;192:160-165. doi: 10.1016/j.lfs.2017.11.026. Epub 2017 Nov 20. Life Sci. 2018. PMID: 29158050 Review.
Years of researches have demonstrated that the imbalance of Th17 and Tregs contribute to the thyroid autoimmunity and the severity of autoimmune thyroid disease (AITD). The underlying mechanism comprises inherent genetic predisposition, abnormality of Th17 …
Years of researches have demonstrated that the imbalance of Th17 and Tregs contribute to the thyroid autoimmunity and the seve …
135 results