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Glutathione transporters.
Bachhawat AK, Thakur A, Kaur J, Zulkifli M. Bachhawat AK, et al. Among authors: thakur a. Biochim Biophys Acta. 2013 May;1830(5):3154-64. doi: 10.1016/j.bbagen.2012.11.018. Epub 2012 Nov 30. Biochim Biophys Acta. 2013. PMID: 23206830 Review.
MAJOR CONCLUSIONS: The molecular identity of a few glutathione transporters has been unambiguously established but there is a need to identify the transporters of other systems and organelles. ...This article is part of a Special Issue entitled Cellular funct …
MAJOR CONCLUSIONS: The molecular identity of a few glutathione transporters has been unambiguously established but there is a
Substrate specificity and mapping of residues critical for transport in the high-affinity glutathione transporter Hgt1p.
Zulkifli M, Yadav S, Thakur A, Singla S, Sharma M, Bachhawat AK. Zulkifli M, et al. Among authors: thakur a. Biochem J. 2016 Aug 1;473(15):2369-82. doi: 10.1042/BCJ20160231. Epub 2016 Jun 1. Biochem J. 2016. PMID: 27252386
To understand the structural features required for interaction with Hgt1p, a quantitative investigation of substrate specificity of Hgt1p was carried out. ...An ab initio model of Hgt1p was built and refined using these mutagenic data that yielded a helical arrangem …
To understand the structural features required for interaction with Hgt1p, a quantitative investigation of substrate specificity of H …
Charged/Polar-residue scanning of the hydrophobic face of transmembrane domain 9 of the yeast glutathione transporter, hgt1p, reveals a conformationally critical region for substrate transport.
Thakur A, Bachhawat AK. Thakur A, et al. G3 (Bethesda). 2015 Mar 16;5(5):921-9. doi: 10.1534/g3.115.017079. G3 (Bethesda). 2015. PMID: 25784163 Free PMC article.
Unraveling the mechanistic workings of membrane transporters has remained a challenging task. We describe a novel strategy that involves subjecting the residues of the hydrophobic face of a transmembrane helix to a charged/polar scanning mutagenesis. . …
Unraveling the mechanistic workings of membrane transporters has remained a challenging task. We describe a novel strategy tha …
Mutations in the N-terminal region of the Schizosaccharomyces pombe glutathione transporter pgt1⁺ allows functional expression in Saccharomyces cerevisiae.
Thakur A, Bachhawat AK. Thakur A, et al. Yeast. 2013 Feb;30(2):45-54. doi: 10.1002/yea.2939. Epub 2012 Dec 20. Yeast. 2013. PMID: 23280723
Pgt1p encodes a glutathione transporter in Schizosaccharomyces pombe, orthologous to the Saccharomyces cerevisiae glutathione transporter, Hgt1p. ...In the present study we employed a genetic strategy to investigate the reason behind the non-functionality of pgt1⁺ i …
Pgt1p encodes a glutathione transporter in Schizosaccharomyces pombe, orthologous to the Saccharomyces cerevisiae glutathione transpo …
Glutathione utilization by Candida albicans requires a functional glutathione degradation (DUG) pathway and OPT7, an unusual member of the oligopeptide transporter family.
Desai PR, Thakur A, Ganguli D, Paul S, Morschhäuser J, Bachhawat AK. Desai PR, et al. Among authors: thakur a. J Biol Chem. 2011 Dec 2;286(48):41183-94. doi: 10.1074/jbc.M111.272377. Epub 2011 Oct 12. J Biol Chem. 2011. PMID: 21994941 Free PMC article.
Biochemical studies on OPT7 using radiolabeled GSH uptake revealed a K(m) of 205 μm, indicating that it was a high affinity glutathione transporter. ...In vivo experiments using a systemic model of candidiasis failed to detect expression of OPT7 in vivo, and …
Biochemical studies on OPT7 using radiolabeled GSH uptake revealed a K(m) of 205 μm, indicating that it was a high affinity gl …
Pgt1, a glutathione transporter from the fission yeast Schizosaccharomyces pombe.
Thakur A, Kaur J, Bachhawat AK. Thakur A, et al. FEMS Yeast Res. 2008 Sep;8(6):916-29. doi: 10.1111/j.1567-1364.2008.00423.x. Epub 2008 Jul 24. FEMS Yeast Res. 2008. PMID: 18662319
The Schizosaccharomyces pombe ORF, SPAC29B12.10c, a predicted member of the oligopeptide transporter (OPT) family, was identified as a gene encoding the S. pombe glutathione transporter (Pgt1) by a genetic strategy that exploited the requirement of the cys1aD …
The Schizosaccharomyces pombe ORF, SPAC29B12.10c, a predicted member of the oligopeptide transporter (OPT) family, was identified as …
The role of transmembrane domain 9 in substrate recognition by the fungal high-affinity glutathione transporters.
Thakur A, Bachhawat AK. Thakur A, et al. Biochem J. 2010 Aug 1;429(3):593-602. doi: 10.1042/BJ20100240. Biochem J. 2010. PMID: 20477749
Phe523 was found to be critical for glutathione recognition, since F523A mutants showed a 4-fold increase in Km without affecting expression or localization. ...Sequence alignments revealed that Phe523 and Gln526 were conserved in a cluster of OPT homologues from di …
Phe523 was found to be critical for glutathione recognition, since F523A mutants showed a 4-fold increase in Km without affecting exp …
Structure and genetic diversity of natural populations of Morus alba in the trans-Himalayan Ladakh region.
Bajpai PK, Warghat AR, Sharma RK, Yadav A, Thakur AK, Srivastava RB, Stobdan T. Bajpai PK, et al. Among authors: thakur ak. Biochem Genet. 2014 Apr;52(3-4):137-52. doi: 10.1007/s10528-013-9634-5. Epub 2013 Nov 16. Biochem Genet. 2014. PMID: 24243146
At a regional level, partitioning of variability assessed using analysis of molecular variance (AMOVA), revealed 80% variation within and 20% among collection sites. Pattern appeared in STRUCTURE, BARRIER, and AMOVA, clearly demonstrating gene flow between the Indus and Su …
At a regional level, partitioning of variability assessed using analysis of molecular variance (AMOVA), revealed 80% variation within …
Convalescent plasma in the management of moderate covid-19 in adults in India: open label phase II multicentre randomised controlled trial (PLACID Trial).
Agarwal A, Mukherjee A, Kumar G, Chatterjee P, Bhatnagar T, Malhotra P; PLACID Trial Collaborators. Agarwal A, et al. BMJ. 2020 Oct 22;371:m3939. doi: 10.1136/bmj.m3939. BMJ. 2020. PMID: 33093056
Genetic diversity in leafy mustard (Brassica juncea var. rugosa) as revealed by agro-morphological traits and SSR markers.
Sharma D, Nanjundan J, Singh L, Singh SP, Parmar N, Sujith Kumar MS, Singh KH, Mishra AK, Singh R, Verma KS, Thakur AK. Sharma D, et al. Among authors: thakur ak. Physiol Mol Biol Plants. 2020 Oct;26(10):2005-2018. doi: 10.1007/s12298-020-00883-2. Epub 2020 Sep 21. Physiol Mol Biol Plants. 2020. PMID: 33088045
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