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Genetic influences on the development of childhood psychiatric disorders.
Thapar A, Stergiakouli E. Thapar A, et al. Psychiatry. 2008 Jul;7(7):277-281. doi: 10.1016/j.mppsy.2008.05.009. Psychiatry. 2008. PMID: 22427711 Free PMC article.
The genetic aetiology of childhood depression: a review.
Rice F, Harold G, Thapar A. Rice F, et al. J Child Psychol Psychiatry. 2002 Jan;43(1):65-79. doi: 10.1111/1469-7610.00004. J Child Psychol Psychiatry. 2002. PMID: 11848337 Review.
Adoption studies show little evidence for a genetic influence on depressive symptoms. CONCLUSIONS: MDD in young people is familial although control group and study design affect the magnitude of the familial risk. ...
Adoption studies show little evidence for a genetic influence on depressive symptoms. CONCLUSIONS: MDD in young people is familial al …
Assessing the effects of age, sex and shared environment on the genetic aetiology of depression in childhood and adolescence.
Rice F, Harold GT, Thapar A. Rice F, et al. J Child Psychol Psychiatry. 2002 Nov;43(8):1039-51. doi: 10.1111/1469-7610.00231. J Child Psychol Psychiatry. 2002. PMID: 12455925
BACKGROUND: Depressive symptoms and disorder are experienced by a significant proportion of young people and have long-lasting deleterious effects. ...There was a significant effect of gender for self-rated depressive symptoms. For boys, genetic factors were of grea …
BACKGROUND: Depressive symptoms and disorder are experienced by a significant proportion of young people and have long-lasting delete …
Depressive symptoms in children and adolescents: changing aetiological influences with development.
Scourfield J, Rice F, Thapar A, Harold GT, Martin N, McGuffin P. Scourfield J, et al. J Child Psychol Psychiatry. 2003 Oct;44(7):968-76. doi: 10.1111/1469-7610.00181. J Child Psychol Psychiatry. 2003. PMID: 14531579
METHOD: Parent and self-report questionnaire data were used to examine the genetic and environmental influences on depressive symptoms in a UK sample of 670 twin pairs aged 5-17. Age effects were examined cross-sectionally and longitudinally using data collected over a
METHOD: Parent and self-report questionnaire data were used to examine the genetic and environmental influences on depressive symptoms in …
Negative life events as an account of age-related differences in the genetic aetiology of depression in childhood and adolescence.
Rice F, Harold GT, Thapar A. Rice F, et al. J Child Psychol Psychiatry. 2003 Oct;44(7):977-87. doi: 10.1111/1469-7610.00182. J Child Psychol Psychiatry. 2003. PMID: 14531580
METHOD: Questionnaires were sent to the families of a population-based sample of twins aged between 8 and 17 years. Parents of all the twins and adolescents aged 11 and over were asked to complete the Mood and Feelings Questionnaire (Costello & Angold, 1988) and a
METHOD: Questionnaires were sent to the families of a population-based sample of twins aged between 8 and 17 years. Parents of all th …
Maternal smoking during pregnancy and attention deficit hyperactivity disorder symptoms in offspring.
Thapar A, Fowler T, Rice F, Scourfield J, van den Bree M, Thomas H, Harold G, Hay D. Thapar A, et al. Am J Psychiatry. 2003 Nov;160(11):1985-9. doi: 10.1176/appi.ajp.160.11.1985. Am J Psychiatry. 2003. PMID: 14594745
METHOD: Children's ADHD symptoms (parent- and teacher-rated), maternal smoking during pregnancy, conduct disorder symptoms, and family adversity were assessed with questionnaires for a population-based sample of twins (1,452 twin pairs 5-16 years of age). RESULTS: Although …
METHOD: Children's ADHD symptoms (parent- and teacher-rated), maternal smoking during pregnancy, conduct disorder symptoms, and family adver …
The Child Attention-Deficit Hyperactivity Disorder Teacher Telephone Interview (CHATTI): reliability and validity.
Holmes J, Lawson D, Langley K, Fitzpatrick H, Trumper A, Pay H, Harrington R, Thapar A. Holmes J, et al. Br J Psychiatry. 2004 Jan;184:74-8. doi: 10.1192/bjp.184.1.74. Br J Psychiatry. 2004. PMID: 14702231 Clinical Trial.
AIMS: To examine the stability, test-retest reliability and criterion validity of the CHATTI for children referred with a suspected diagnosis of ADHD. ...CONCLUSIONS: The CHATTI appears to be a promising tool for assessing ADHD symptoms in a school setting an …
AIMS: To examine the stability, test-retest reliability and criterion validity of the CHATTI for children referred with a suspected d …
No evidence of association between Catechol-O-Methyltransferase (COMT) Val158Met genotype and performance on neuropsychological tasks in children with ADHD: a case-control study.
Mills S, Langley K, Van den Bree M, Street E, Turic D, Owen MJ, O'Donovan MC, Thapar A. Mills S, et al. BMC Psychiatry. 2004 Jun 7;4:15. doi: 10.1186/1471-244X-4-15. BMC Psychiatry. 2004. PMID: 15182372 Free PMC article.
METHODS: We set out to examine the association between the Val158Met polymorphism and performance on neurocognitive tasks including those tapping working memory, attention and speed, impulsiveness and response inhibition in a sample of 124 children with ADHD. ...
METHODS: We set out to examine the association between the Val158Met polymorphism and performance on neurocognitive tasks including those ta …
A population-based study of anxiety as a precursor for depression in childhood and adolescence.
Rice F, van den Bree MB, Thapar A. Rice F, et al. BMC Psychiatry. 2004 Dec 13;4:43. doi: 10.1186/1471-244X-4-43. BMC Psychiatry. 2004. PMID: 15596007 Free PMC article.
Although there is some evidence to suggest that the association between early anxiety and later depression is explained by a shared genetic aetiology, the contribution of environmental factors is less well examined and it is unknown whether anxiety itself is a pheno …
Although there is some evidence to suggest that the association between early anxiety and later depression is explained by a shared g …
A family based study implicates solute carrier family 1-member 3 (SLC1A3) gene in attention-deficit/hyperactivity disorder.
Turic D, Langley K, Williams H, Norton N, Williams NM, Moskvina V, Van den Bree MB, Owen MJ, Thapar A, O'Donovan MC. Turic D, et al. Biol Psychiatry. 2005 Jun 1;57(11):1461-6. doi: 10.1016/j.biopsych.2005.03.025. Biol Psychiatry. 2005. PMID: 15950021
The SLC1A3 (Solute Carrier Family 1, member 3) gene encodes a glial glutamate transporter which maps to chromosome 5p12, a region of linkage that coincides in two published ADHD genome scans so far. ...RESULTS: In a family-based sample (n = 299) we found a
The SLC1A3 (Solute Carrier Family 1, member 3) gene encodes a glial glutamate transporter which maps to chromosome 5p12, a reg …
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