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Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans.
GTEx Consortium. GTEx Consortium. Science. 2015 May 8;348(6235):648-60. doi: 10.1126/science.1262110. Epub 2015 May 7. Science. 2015. PMID: 25954001 Free PMC article.
Understanding the functional consequences of genetic variation, and how it affects complex human disease and quantitative traits, remains a critical challenge for biomedicine. We present an analysis of RNA sequencing data from 1641 samples across 43 tissues from 175 indivi …
Understanding the functional consequences of genetic variation, and how it affects complex human disease and quantitative traits, remains a …
A multi-tissue atlas of regulatory variants in cattle.
Liu S, Gao Y, Canela-Xandri O, Wang S, Yu Y, Cai W, Li B, Xiang R, Chamberlain AJ, Pairo-Castineira E, D'Mellow K, Rawlik K, Xia C, Yao Y, Navarro P, Rocha D, Li X, Yan Z, Li C, Rosen BD, Van Tassell CP, Vanraden PM, Zhang S, Ma L, Cole JB, Liu GE, Tenesa A, Fang L. Liu S, et al. Nat Genet. 2022 Sep;54(9):1438-1447. doi: 10.1038/s41588-022-01153-5. Epub 2022 Aug 11. Nat Genet. 2022. PMID: 35953587 Free PMC article.
Characterization of genetic regulatory variants acting on livestock gene expression is essential for interpreting the molecular mechanisms underlying traits of economic value and for increasing the rate of genetic gain through artificial selection. Here we build a C …
Characterization of genetic regulatory variants acting on livestock gene expression is essential for interpreting the molecula …
Cautions should be taken when using cell models for gastric cancer research.
Cai S, Yao D, Zhang Y, Li Z, Li X, Li L. Cai S, et al. Gene. 2022 Jan 5;806:145922. doi: 10.1016/j.gene.2021.145922. Epub 2021 Aug 26. Gene. 2022. PMID: 34454032
Selected datasets from TCGA (The Cancer Genome Atlas), CCLE (The Broad Institute Cancer Cell Line Encyclopedia), and GTEx (The Genotype-Tissue Expression project) were used to represent GCs, GC-derived cell lines, and healthy tissues respectively in th …
Selected datasets from TCGA (The Cancer Genome Atlas), CCLE (The Broad Institute Cancer Cell Line Encyclopedia), and GTEx (The Gen …
Context Specific and Differential Gene Co-expression Networks via Bayesian Biclustering.
Gao C, McDowell IC, Zhao S, Brown CD, Engelhardt BE. Gao C, et al. PLoS Comput Biol. 2016 Jul 28;12(7):e1004791. doi: 10.1371/journal.pcbi.1004791. eCollection 2016 Jul. PLoS Comput Biol. 2016. PMID: 27467526 Free PMC article.
Further, we develop a principled method to recover context specific gene co-expression networks from the estimated sparse biclustering matrices. We apply BicMix to breast cancer gene expression data and to gene expression data from a card …
Further, we develop a principled method to recover context specific gene co-expression networks from the estimated sparse bicl …