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The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop.
Yasukawa H, Misawa H, Sakamoto H, Masuhara M, Sasaki A, Wakioka T, Ohtsuka S, Imaizumi T, Matsuda T, Ihle JN, Yoshimura A. Yasukawa H, et al. EMBO J. 1999 Mar 1;18(5):1309-20. doi: 10.1093/emboj/18.5.1309. EMBO J. 1999. PMID: 10064597 Free PMC article.
However, compared with other kinases, little is known about cellular regulators of the JAKs. We have recently identified a JAK-binding protein (JAB) that inhibits JAK signaling in cells. In the studies presented here we demonstrate …
However, compared with other kinases, little is known about cellular regulators of the JAKs. We have recently identified a JAK
Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain.
Sasaki A, Yasukawa H, Suzuki A, Kamizono S, Syoda T, Kinjyo I, Sasaki M, Johnston JA, Yoshimura A. Sasaki A, et al. Genes Cells. 1999 Jun;4(6):339-51. doi: 10.1046/j.1365-2443.1999.00263.x. Genes Cells. 1999. PMID: 10421843 Free article.
JAB inhibits JAK2 tyrosine kinase activity by binding to the kinase domain (JH1 domain) through the N-terminal kinase inhibitory region (KIR) and the SH2 domain. ...CONCLUSION: CIS3 inhibits JAK2 kinase acti
JAB inhibits JAK2 tyrosine kinase activity by binding to the kinase domain (JH1 domain) thr
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