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Page 1
Did you mean the t cell (203 results)?
Proteomic analyses identify targets, pathways, and cellular consequences of oncogenic KRAS signaling.
Kabella N, Bayer FP, Stamatiou K, Abele M, Sakhteman A, Chang YC, Wagner V, Gabriel A, Krumm J, Reinecke M, Holzner M, Aigner M, The M, Hahne H, Bassermann F, Ludwig C, Vagnarelli P, Kuster B. Kabella N, et al. Among authors: the m. Sci Signal. 2025 Jul 29;18(897):eadt6552. doi: 10.1126/scisignal.adt6552. Epub 2025 Jul 29. Sci Signal. 2025. PMID: 40729433
Comparisons of phosphoproteomes between cell lines revealed a core KRAS signaling signature and cell line-specific signaling networks. ...The collective data reveal insights into oncogenic KRAS signaling, place many additional proteins into this functional context, …
Comparisons of phosphoproteomes between cell lines revealed a core KRAS signaling signature and cell line-specific signaling n …
Decrypting drug actions and protein modifications by dose- and time-resolved proteomics.
Zecha J, Bayer FP, Wiechmann S, Woortman J, Berner N, Müller J, Schneider A, Kramer K, Abril-Gil M, Hopf T, Reichart L, Chen L, Hansen FM, Lechner S, Samaras P, Eckert S, Lautenbacher L, Reinecke M, Hamood F, Prokofeva P, Vornholz L, Falcomatà C, Dorsch M, Schröder A, Venhuizen A, Wilhelm S, Médard G, Stoehr G, Ruland J, Grüner BM, Saur D, Buchner M, Ruprecht B, Hahne H, The M, Wilhelm M, Kuster B. Zecha J, et al. Among authors: the m. Science. 2023 Apr 7;380(6640):93-101. doi: 10.1126/science.ade3925. Epub 2023 Mar 16. Science. 2023. PMID: 36926954 Free PMC article.
In this work, we introduce a proteomic assay called decryptM that quantifies drug-PTM modulation for thousands of PTMs in cells to shed light on target engagement and drug mechanism of action. Examples range from detecting DNA damage by chemotherapeutics, to identifying dr …
In this work, we introduce a proteomic assay called decryptM that quantifies drug-PTM modulation for thousands of PTMs in cells to sh …
Gemcitabine and ATR inhibitors synergize to kill PDAC cells by blocking DNA damage response.
Höfer S, Frasch L, Brajkovic S, Putzker K, Lewis J, Schürmann H, Leone V, Sakhteman A, The M, Bayer FP, Müller J, Hamood F, Siveke JT, Reichert M, Kuster B. Höfer S, et al. Among authors: the m. Mol Syst Biol. 2025 Mar;21(3):231-253. doi: 10.1038/s44320-025-00085-6. Epub 2025 Jan 21. Mol Syst Biol. 2025. PMID: 39838187 Free PMC article.
Here, we phenotypically screened 13 human pancreatic adenocarcinoma (PDAC) cell lines against GEM in combination with 146 clinical inhibitors and observed strong synergy for the ATR kinase inhibitor Elimusertib in most cell lines. ...
Here, we phenotypically screened 13 human pancreatic adenocarcinoma (PDAC) cell lines against GEM in combination with 146 clinical in …
Mass spectrometry-based draft of the mouse proteome.
Giansanti P, Samaras P, Bian Y, Meng C, Coluccio A, Frejno M, Jakubowsky H, Dobiasch S, Hazarika RR, Rechenberger J, Calzada-Wack J, Krumm J, Mueller S, Lee CY, Wimberger N, Lautenbacher L, Hassan Z, Chang YC, Falcomatà C, Bayer FP, Bärthel S, Schmidt T, Rad R, Combs SE, The M, Johannes F, Saur D, de Angelis MH, Wilhelm M, Schneider G, Kuster B. Giansanti P, et al. Among authors: the m. Nat Methods. 2022 Jul;19(7):803-811. doi: 10.1038/s41592-022-01526-y. Epub 2022 Jun 16. Nat Methods. 2022. PMID: 35710609 Free PMC article.
Here, we present a quantitative draft of the mouse proteome and phosphoproteome constructed from 41 healthy tissues and several lines of analyses exemplify which insights can be gleaned from the data. For instance, tissue- and cell-type resolved profiles provide protein ev …
Here, we present a quantitative draft of the mouse proteome and phosphoproteome constructed from 41 healthy tissues and several lines of ana …
Prosit-TMT: Deep Learning Boosts Identification of TMT-Labeled Peptides.
Gabriel W, The M, Zolg DP, Bayer FP, Shouman O, Lautenbacher L, Schnatbaum K, Zerweck J, Knaute T, Delanghe B, Huhmer A, Wenschuh H, Reimer U, Médard G, Kuster B, Wilhelm M. Gabriel W, et al. Among authors: the m. Anal Chem. 2022 May 24;94(20):7181-7190. doi: 10.1021/acs.analchem.1c05435. Epub 2022 May 12. Anal Chem. 2022. PMID: 35549156
It is a standard workflow in proteomics ranging from single-cell to high-throughput proteomics. Particularly for TMT, increasing the number of confidently identified spectra is highly desirable as it provides identification and quantification information with every spectru …
It is a standard workflow in proteomics ranging from single-cell to high-throughput proteomics. Particularly for TMT, increasing the …
Human insulin: DNA technology's first drug.
The MJ. The MJ. Am J Hosp Pharm. 1989 Nov;46(11 Suppl 2):S9-11. Am J Hosp Pharm. 1989. PMID: 2690608 Review.
The human genetic coding for proinsulin is inserted into Escherichia coli cells, which are then grown by fermentation to produce proinsulin. The connecting peptide is cleaved enzymatically from proinsulin to produce human insulin. ...
The human genetic coding for proinsulin is inserted into Escherichia coli cells, which are then grown by fermentation to produce proi …
Decrypting lysine deacetylase inhibitor action and protein modifications by dose-resolved proteomics.
Chang YC, Gnann C, Steimbach RR, Bayer FP, Lechner S, Sakhteman A, Abele M, Zecha J, Trendel J, The M, Lundberg E, Miller AK, Kuster B. Chang YC, et al. Among authors: the m. Cell Rep. 2024 Jun 25;43(6):114272. doi: 10.1016/j.celrep.2024.114272. Epub 2024 May 24. Cell Rep. 2024. PMID: 38795348 Free article.
Lysine deacetylase inhibitors (KDACis) are approved drugs for cutaneous T cell lymphoma (CTCL), peripheral T cell lymphoma (PTCL), and multiple myeloma, but many aspects of their cellular mechanism of action (MoA) and substantial toxicity are not well understood. .. …
Lysine deacetylase inhibitors (KDACis) are approved drugs for cutaneous T cell lymphoma (CTCL), peripheral T cell lymphoma (PT …
The Use of a Staggered Herringbone Micromixer for the Preparation of Rigid Liposomal Formulations Allows Efficient Encapsulation of Antigen and Adjuvant.
Lozano Vigario F, Nagy NA, The MH, Sparrius R, Bouwstra JA, Kros A, Jiskoot W, de Jong EC, Slütter B. Lozano Vigario F, et al. Among authors: the mh. J Pharm Sci. 2022 Apr;111(4):1050-1057. doi: 10.1016/j.xphs.2022.01.029. Epub 2022 Jan 31. J Pharm Sci. 2022. PMID: 35114210 Free article.
Furthermore, we show that the system allows for the encapsulation of a wide variety of peptides and significantly higher loading efficiency of 1-alpha,25-dihydroxyvitaminD3 compared to the traditional lipid film hydration method, without compromising their non-inflammatory intera …
Furthermore, we show that the system allows for the encapsulation of a wide variety of peptides and significantly higher loading efficiency …
18 results