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The Apoptotic Engulfment Machinery Regulates Axonal Degeneration in C. elegans Neurons.
Nichols ALA, Meelkop E, Linton C, Giordano-Santini R, Sullivan RK, Donato A, Nolan C, Hall DH, Xue D, Neumann B, Hilliard MA. Nichols ALA, et al. Cell Rep. 2016 Feb 23;14(7):1673-1683. doi: 10.1016/j.celrep.2016.01.050. Epub 2016 Feb 11. Cell Rep. 2016. PMID: 26876181 Free PMC article.
Axonal degeneration is a characteristic feature of neurodegenerative disease and nerve injury. ...Thus, our results reveal the existence of a WLD(S)/Nmnat-independent axonal degeneration pathway, conservation of the axonal clearance machinery
Axonal degeneration is a characteristic feature of neurodegenerative disease and nerve injury. ...Thus, our results reveal the
The Core Molecular Machinery Used for Engulfment of Apoptotic Cells Regulates the JNK Pathway Mediating Axon Regeneration in Caenorhabditis elegans.
Pastuhov SI, Fujiki K, Tsuge A, Asai K, Ishikawa S, Hirose K, Matsumoto K, Hisamoto N. Pastuhov SI, et al. J Neurosci. 2016 Sep 14;36(37):9710-21. doi: 10.1523/JNEUROSCI.0453-16.2016. J Neurosci. 2016. PMID: 27629720 Free PMC article.
This module is also known to regulate the engulfment of apoptotic cells during development. Our findings thus reveal that the molecular machinery used for engulfment of apoptotic cells also promotes axon regeneration through activation of …
This module is also known to regulate the engulfment of apoptotic cells during development. Our findings thus reveal th …