The glomerular filtration barrier: a structural target for novel kidney therapies.
Nat Rev Drug Discov. 2021.
PMID: 34262140
Free PMC article.
Review.
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The glomerular filtration barrier: a structural target for novel kidney therapies.
Nat Rev Drug Discov. 2021 Oct;20(10):770-788. doi: 10.1038/s41573-021-00242-0. Epub 2021 Jul 14.
Nat Rev Drug Discov. 2021.
PMID: 34262140
Free PMC article.
Review.
Most kidney disease is characterized by breakdown of the glomerular filtration barrier (GFB). Specialized podocyte cells maintain the GFB, and structure-function experiments and studies of intercellular communication between the podocytes and ot …
Most kidney disease is characterized by breakdown of the glomerular filtration barrier (GFB). Specialized podocy …
Wogonin protects glomerular podocytes by targeting Bcl-2-mediated autophagy and apoptosis in diabetic kidney disease.
Acta Pharmacol Sin. 2022 Jan;43(1):96-110. doi: 10.1038/s41401-021-00721-5. Epub 2021 Jul 12.
Acta Pharmacol Sin. 2022.
PMID: 34253875
Free PMC article.
Diabetic kidney disease (DKD) is one of the microvascular complications of diabetes mellitus and a major cause of end-stage renal disease with limited treatment options. ...In this study, we investigated the effects of wogonin on glomerular podocytes in DKD using mo …
Diabetic kidney disease (DKD) is one of the microvascular complications of diabetes mellitus and a major cause of end-stage renal dis …
Novel therapies for FSGS: preclinical and clinical studies.
Adv Chronic Kidney Dis. 2015 Mar;22(2):e1-6. doi: 10.1053/j.ackd.2014.10.001.
Adv Chronic Kidney Dis. 2015.
PMID: 25704355
Free PMC article.
Review.
Focal segmental glomerulosclerosis (FSGS) is a rare but important cause of end-stage kidney disease in children and adults. Current therapy, consisting of corticosteroids and calcineurin inhibitors, fails to achieve a sustained remission in most patients. ...Despite …
Focal segmental glomerulosclerosis (FSGS) is a rare but important cause of end-stage kidney disease in children and adults. Current …
Bioengineering Strategies to Develop Podocyte Culture Systems.
Tissue Eng Part B Rev. 2022 Aug;28(4):938-948. doi: 10.1089/ten.TEB.2021.0154. Epub 2021 Dec 8.
Tissue Eng Part B Rev. 2022.
PMID: 34541902
Free PMC article.
Review.
Finally, we discuss various considerations and potential engineering strategies for developing next-generation complex 3D culture models for studying podocyte behaviors in vitro. Impact Statement In various glomerular kidney diseases, there are numerous alterations …
Finally, we discuss various considerations and potential engineering strategies for developing next-generation complex 3D culture models for …
Podocytes from the diagnostic and therapeutic point of view.
Pflugers Arch. 2017 Aug;469(7-8):1007-1015. doi: 10.1007/s00424-017-1993-z. Epub 2017 May 16.
Pflugers Arch. 2017.
PMID: 28508947
Review.
The central role of podocytes in glomerular diseases makes this cell type an interesting diagnostic tool as well as a therapeutic target. ...Incubation of cultured human podocyte cell lines with sera from patients with active glomerular diseases is currently …
The central role of podocytes in glomerular diseases makes this cell type an interesting diagnostic tool as well as a therapeutic …
Actin dynamics at focal adhesions: a common endpoint and putative therapeutic target for proteinuric kidney diseases.
Kidney Int. 2018 Jun;93(6):1298-1307. doi: 10.1016/j.kint.2017.12.028. Epub 2018 Apr 17.
Kidney Int. 2018.
PMID: 29678354
Free PMC article.
Review.
The basis of proteinuria is a disturbance in size selectivity of the glomerular filtration barrier, which largely depends on the podocyte: a terminally differentiated epithelial cell type covering the outer surface of the glomerulus. ...Numerous studies withi …
The basis of proteinuria is a disturbance in size selectivity of the glomerular filtration barrier, which largely depen …
Glomerular Biomechanical Stress and Lipid Mediators during Cellular Changes Leading to Chronic Kidney Disease.
Biomedicines. 2022 Feb 9;10(2):407. doi: 10.3390/biomedicines10020407.
Biomedicines. 2022.
PMID: 35203616
Free PMC article.
Review.
Hyperfiltration is an important underlying cause of glomerular dysfunction associated with several systemic and intrinsic glomerular conditions leading to chronic kidney disease (CKD). ...Ongoing research suggests these biomechanical forces as the initial med …
Hyperfiltration is an important underlying cause of glomerular dysfunction associated with several systemic and intrinsic glomerul …
Toward the development of podocyte-specific drugs.
Kidney Int. 2010 Apr;77(8):662-8. doi: 10.1038/ki.2009.559. Epub 2010 Feb 3.
Kidney Int. 2010.
PMID: 20130528
Free PMC article.
Review.
Most glomerulopathies directly stem from injury to podocytes, cells that have a key role in the maintenance of the glomerular filter. Thus, these cells constitute an obvious and promising target for the development of novel kidney-protective drugs. ... …
Most glomerulopathies directly stem from injury to podocytes, cells that have a key role in the maintenance of the glomerular filter. …
Signal transduction in podocytes--spotlight on receptor tyrosine kinases.
Nat Rev Nephrol. 2014 Feb;10(2):104-15. doi: 10.1038/nrneph.2013.274. Epub 2014 Jan 7.
Nat Rev Nephrol. 2014.
PMID: 24394191
Free PMC article.
Review.
The mammalian kidney filtration barrier is a complex multicellular, multicomponent structure that maintains homeostasis by regulating electrolytes, acid-base balance, and blood pressure (via maintenance of salt and water balance). ...Pharmacological in …
The mammalian kidney filtration barrier is a complex multicellular, multicomponent structure that maintains home …
G-protein coupled receptor GPR124 protects against podocyte senescence and injury in diabetic kidney disease.
Kidney Int. 2025 Apr;107(4):652-665. doi: 10.1016/j.kint.2024.12.013. Epub 2025 Jan 17.
Kidney Int. 2025.
PMID: 39828038
Here, we identified a previously unrecognized role of GPR124, a novel adhesion G protein-coupled receptor, in maintaining podocyte structure and function by regulation of cellular senescence in DKD. Podocyte GPR124 was significantly reduced in db/db diabetic (a type …
Here, we identified a previously unrecognized role of GPR124, a novel adhesion G protein-coupled receptor, in maintaining podocyte …
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