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The human zygote inherits its mitotic potential from the male gamete.
Palermo G, Munné S, Cohen J. Palermo G, et al. Hum Reprod. 1994 Jul;9(7):1220-5. doi: 10.1093/oxfordjournals.humrep.a138682. Hum Reprod. 1994. PMID: 7962421
The centrosome used for development in most species is paternally inherited, with the exception of the mouse. Single and double centrioles within centrosomes in human zygotes have been described. Interpretation of data suggests that sperm centrioles are assoc …
The centrosome used for development in most species is paternally inherited, with the exception of the mouse. Single and double centr …
Centromere Dynamics in Male and Female Germ Cells.
Dunleavy EM, Collins CM. Dunleavy EM, et al. Prog Mol Subcell Biol. 2017;56:357-375. doi: 10.1007/978-3-319-58592-5_15. Prog Mol Subcell Biol. 2017. PMID: 28840245 Review.
In sexually reproducing organisms the germ line is the cellular lineage that gives rise to gametes. All germ cells originate from germline stem cells that divide asymmetrically to generate gonial pre-cursors, which are amplified in number by …
In sexually reproducing organisms the germ line is the cellular lineage that gives rise to gametes. All germ cells …
Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease.
Hyslop LA, Blakeley P, Craven L, Richardson J, Fogarty NM, Fragouli E, Lamb M, Wamaitha SE, Prathalingam N, Zhang Q, O'Keefe H, Takeda Y, Arizzi L, Alfarawati S, Tuppen HA, Irving L, Kalleas D, Choudhary M, Wells D, Murdoch AP, Turnbull DM, Niakan KK, Herbert M. Hyslop LA, et al. Nature. 2016 Jun 16;534(7607):383-6. doi: 10.1038/nature18303. Epub 2016 Jun 8. Nature. 2016. PMID: 27281217 Free PMC article.
Mitochondrial DNA (mtDNA) mutations are maternally inherited and are associated with a broad range of debilitating and fatal diseases. Reproductive technologies designed to uncouple the inheritance of mtDNA from nuclear DNA may enable affected women to have a geneti …
Mitochondrial DNA (mtDNA) mutations are maternally inherited and are associated with a broad range of debilitating and fatal diseases …
Molecular medical approaches for alleviating infertility and understanding assisted reproductive technologies.
Sutovsky P, Hewitson L, Simerly C, Schatten G. Sutovsky P, et al. Proc Assoc Am Physicians. 1996 Nov;108(6):432-43. Proc Assoc Am Physicians. 1996. PMID: 8956366 Review.
Rodents such as the rat, mouse, and hamster are poor models owing to their maternal inheritance of the zygotic centrosome that is in strong contrast with the biparentally contributed assembly of the human zygotic centrosome during fertilization. Althou …
Rodents such as the rat, mouse, and hamster are poor models owing to their maternal inheritance of the zygotic centrosome that …