Effect of inorganic nitrate on exercise capacity in heart failure with preserved ejection fraction.
Circulation. 2015.
PMID: 25533966
Free PMC article.
Clinical Trial.
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Interleukin-6 in Patients With Heart Failure and Preserved Ejection Fraction.
JACC Heart Fail. 2023 Nov;11(11):1549-1561. doi: 10.1016/j.jchf.2023.06.031. Epub 2023 Aug 9.
JACC Heart Fail. 2023.
PMID: 37565977
Free PMC article.
BACKGROUND: Interleukin (IL)-6 is a central inflammatory mediator and potential therapeutic target in heart failure (HF). Prior studies have shown that IL-6 concentrations are elevated in patients with HF, but much fewer data are available in heart failure …
BACKGROUND: Interleukin (IL)-6 is a central inflammatory mediator and potential therapeutic target in heart failure (HF). Prio …
Potassium Nitrate in Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial.
JAMA Cardiol. 2025 Mar 1;10(3):284-289. doi: 10.1001/jamacardio.2024.4417.
JAMA Cardiol. 2025.
PMID: 39693096
Free PMC article.
Clinical Trial.
IMPORTANCE: Nitric oxide deficiency may contribute to exercise intolerance in patients with heart failure with preserved ejection fraction (HFpEF). Prior pilot studies have shown improvements in exercise tolerance with single-do …
IMPORTANCE: Nitric oxide deficiency may contribute to exercise intolerance in patients with heart failure with prese …
Efficacy and Safety of Inorganic Nitrate Versus Placebo Treatment in Heart Failure with Preserved Ejection Fraction.
Cardiovasc Drugs Ther. 2020 Aug;34(4):503-513. doi: 10.1007/s10557-020-06980-4.
Cardiovasc Drugs Ther. 2020.
PMID: 32394177
BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is common, yet there is a lack of effective treatments. ...No study has reported the effect of inorganic nitrate on hospitalization and mortality of p …
BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is common, yet there is a lack of e …
The Nitrate-Nitrite-NO Pathway and Its Implications for Heart Failure and Preserved Ejection Fraction.
Curr Heart Fail Rep. 2016 Feb;13(1):47-59. doi: 10.1007/s11897-016-0277-9.
Curr Heart Fail Rep. 2016.
PMID: 26792295
Free PMC article.
Review.
The pathogenesis of exercise intolerance in patients with heart failure and preserved ejection fraction (HFpEF) is likely multifactorial. ...In a recently completed randomized trial, the administration of a single dose of exogenous …
The pathogenesis of exercise intolerance in patients with heart failure and preserved ejection fractio …
Exercise limitations in heart failure with reduced and preserved ejection fraction.
J Appl Physiol (1985). 2018 Jan 1;124(1):208-224. doi: 10.1152/japplphysiol.00747.2017. Epub 2017 Oct 19.
J Appl Physiol (1985). 2018.
PMID: 29051336
Free PMC article.
Review.
The hallmark symptom of chronic heart failure (HF) is severe exercise intolerance. Impaired perfusive and diffusive O(2) transport are two of the major determinants of reduced physical capacity and lowered maximal O(2) uptake in patients with HF. It ha …
The hallmark symptom of chronic heart failure (HF) is severe exercise intolerance. Impaired perfusive and diffusive O(2 …
Pharmacokinetics and Pharmacodynamics of Inorganic Nitrate in Heart Failure With Preserved Ejection Fraction.
Circ Res. 2017 Mar 31;120(7):1151-1161. doi: 10.1161/CIRCRESAHA.116.309832. Epub 2016 Dec 7.
Circ Res. 2017.
PMID: 27927683
Free PMC article.
Clinical Trial.
RATIONALE: Nitrate-rich beetroot juice has been shown to improve exercise capacity in heart failure with preserved ejection fraction, but studies using pharmacological preparations of inorganic nitrate are lack …
RATIONALE: Nitrate-rich beetroot juice has been shown to improve exercise capacity in heart failure with …
INDIE-HFpEF (Inorganic Nitrite Delivery to Improve Exercise Capacity in Heart Failure With Preserved Ejection Fraction): Rationale and Design.
Circ Heart Fail. 2017 May;10(5):e003862. doi: 10.1161/CIRCHEARTFAILURE.117.003862.
Circ Heart Fail. 2017.
PMID: 28476756
Free PMC article.
Review.
Approximately half of patients with heart failure have preserved ejection fraction. There is no proven treatment that improves outcome. ...Herein, we present the rationale and design for the INDIE-HFpEF trial (Inorganic Nitrite Delivery t …
Approximately half of patients with heart failure have preserved ejection fraction. There is no proven tr …
Distinct Impact of Noncardiac Comorbidities on Exercise Capacity and Functional Status in Chronic Heart Failure.
JACC Heart Fail. 2023 Oct;11(10):1365-1376. doi: 10.1016/j.jchf.2023.05.018. Epub 2023 Jun 28.
JACC Heart Fail. 2023.
PMID: 37389503
Free article.
BACKGROUND: Noncardiac comorbidities (NCCs) are common in patients with heart failure (HF), but how they jointly affect exercise capacity and functional status is relatively unexplored. OBJECTIVES: This study sought to investigate the cumulative eff …
BACKGROUND: Noncardiac comorbidities (NCCs) are common in patients with heart failure (HF), but how they jointly affect exe …
Advances in the pharmacotherapy of chronic heart failure with preserved ejection fraction: an ideal opportunity for precision medicine.
Expert Opin Pharmacother. 2017 Mar;18(4):399-409. doi: 10.1080/14656566.2017.1288717. Epub 2017 Feb 17.
Expert Opin Pharmacother. 2017.
PMID: 28129699
Free PMC article.
Review.
Heart failure with preserved ejection fraction (HFpEF), which comprises approximately 50% of all heart failure patients, is a challenging and complex clinical syndrome that is often thought to lack effective treatments. Area …
Heart failure with preserved ejection fraction (HFpEF), which comprises approximately 50% of all heart …
Efficacy and safety of inorganic nitrate/nitrite supplementary therapy in heart failure with preserved ejection fraction.
Front Cardiovasc Med. 2023 Feb 2;10:1054666. doi: 10.3389/fcvm.2023.1054666. eCollection 2023.
Front Cardiovasc Med. 2023.
PMID: 36818337
Free PMC article.
BACKGROUND: Approximately half of patients with heart failure have a preserved ejection fraction (HFpEF). To date, only SGLT-2i, ARNi, and MRAs treatments have been shown to be effective for HFpEF. Exercise intolerance is the prima …
BACKGROUND: Approximately half of patients with heart failure have a preserved ejection fraction (HFpEF). …
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