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The mitochondrial chaperone TRAP1 promotes neoplastic growth by inhibiting succinate dehydrogenase.
Sciacovelli M, Guzzo G, Morello V, Frezza C, Zheng L, Nannini N, Calabrese F, Laudiero G, Esposito F, Landriscina M, Defilippi P, Bernardi P, Rasola A. Sciacovelli M, et al. Cell Metab. 2013 Jun 4;17(6):988-999. doi: 10.1016/j.cmet.2013.04.019. Cell Metab. 2013. PMID: 23747254 Free PMC article.
We report that the mitochondrial chaperone TRAP1, which is induced in most tumor types, is required for neoplastic growth and confers transforming potential to noncancerous cells. TRAP1 binds to and inhibits succinate deh
We report that the mitochondrial chaperone TRAP1, which is induced in most tumor types, is required for neoplastic
Inhibition of succinate dehydrogenase by the mitochondrial chaperone TRAP1 has anti-oxidant and anti-apoptotic effects on tumor cells.
Guzzo G, Sciacovelli M, Bernardi P, Rasola A. Guzzo G, et al. Oncotarget. 2014 Dec 15;5(23):11897-908. doi: 10.18632/oncotarget.2472. Oncotarget. 2014. PMID: 25564869 Free PMC article.
TRAP1 is a mitochondrial chaperone highly expressed in many tumor types; it inhibits respiratory complex II, down-modulating its succinate dehydrogenase (SDH) enzymatic activity. SDH inhibition in turn leads to a pseudohypoxic stat
TRAP1 is a mitochondrial chaperone highly expressed in many tumor types; it inhibits respiratory complex II, dow
Absence of Neurofibromin Induces an Oncogenic Metabolic Switch via Mitochondrial ERK-Mediated Phosphorylation of the Chaperone TRAP1.
Masgras I, Ciscato F, Brunati AM, Tibaldi E, Indraccolo S, Curtarello M, Chiara F, Cannino G, Papaleo E, Lambrughi M, Guzzo G, Gambalunga A, Pizzi M, Guzzardo V, Rugge M, Vuljan SE, Calabrese F, Bernardi P, Rasola A. Masgras I, et al. Cell Rep. 2017 Jan 17;18(3):659-672. doi: 10.1016/j.celrep.2016.12.056. Cell Rep. 2017. PMID: 28099845 Free article.
Here, we report that cells lacking neurofibromin exhibit enhanced glycolysis and decreased respiration in a Ras/ERK-dependent way. In the mitochondrial matrix of neurofibromin-deficient cells, a fraction of active ERK1/2 associates with succinate dehydrogenase
Here, we report that cells lacking neurofibromin exhibit enhanced glycolysis and decreased respiration in a Ras/ERK-dependent way. In the …