The prevalence and clinical correlates of apathy and irritability in Alzheimer's disease.
Eur J Neurol. 1995.
PMID: 24283780
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The prevalence and clinical correlates of apathy and irritability in Alzheimer's disease.
Eur J Neurol. 1995 Dec;2(6):540-6. doi: 10.1111/j.1468-1331.1995.tb00171.x.
Eur J Neurol. 1995.
PMID: 24283780
We examined the prevalence and correlates of apathy and irritability in a consecutive series of 101 patients with probable Alzheimer's disease (AD). Based on clinical criteria, 46 (46%) patients had apathy, and 13 (13%) pati …
We examined the prevalence and correlates of apathy and irritability in a consecutive series of 101 patients wit …
Clinical Correlates of Depression and Suicidality in Huntington Disease: An Analysis of the Enroll-HD Observational Study.
Cogn Behav Neurol. 2022 Jun 1;35(2):85-94. doi: 10.1097/WNN.0000000000000301.
Cogn Behav Neurol. 2022.
PMID: 35486527
BACKGROUND: Depression and suicidality are commonly experienced by Huntington disease (HD) gene carriers. Research on these behavioral symptoms is imperative, not only to increase our understanding of the symptoms and how they relate to HD, but also to contribute to improv …
BACKGROUND: Depression and suicidality are commonly experienced by Huntington disease (HD) gene carriers. Research on these behaviora …
Neuropsychiatric symptoms in mild cognitive impairment and early Alzheimer's disease: Clinical pattern and diagnostic implications.
AIMS Neurosci. 2025 Dec 18;12(4):676-705. doi: 10.3934/Neuroscience.2025032. eCollection 2025.
AIMS Neurosci. 2025.
PMID: 41523330
Free PMC article.
Review.
However, neuropsychiatric symptoms (NPS), including depression, apathy, anxiety, irritability, and sleep disturbances, are increasingly prevalent in the early stages of these conditions and significantly influence the disease trajectory and patient out …
However, neuropsychiatric symptoms (NPS), including depression, apathy, anxiety, irritability, and sleep disturbances, are inc …
Clinical Trajectories of Neuropsychiatric Symptoms in Mild-Moderate to Advanced Dementia.
J Alzheimers Dis. 2022;86(2):861-875. doi: 10.3233/JAD-215133.
J Alzheimers Dis. 2022.
PMID: 35147532
RESULTS: Overall prevalence of NPS was 94.6%, being apathy the most prevalent (66.7%) and the one whose severity increased the most with progression of dementia. ...CONCLUSION: NPS in dementia follow a heterogeneous course. Apathy is the most preval …
RESULTS: Overall prevalence of NPS was 94.6%, being apathy the most prevalent (66.7%) and the one whose severity increa …
The neuropsychiatric profile of posterior cortical atrophy.
J Geriatr Psychiatry Neurol. 2015 Jun;28(2):136-44. doi: 10.1177/0891988714554713. Epub 2014 Oct 20.
J Geriatr Psychiatry Neurol. 2015.
PMID: 25330926
We analyzed scores obtained at the Neuropsychiatric Inventory (NPI) by 20 patients with posterior cortical atrophy (PCA) and contrasted it with 20 patients having Alzheimer disease (AD). Patients with hallucinations and delusions were not included due to the high pr …
We analyzed scores obtained at the Neuropsychiatric Inventory (NPI) by 20 patients with posterior cortical atrophy (PCA) and contrasted it w …
Neuropsychiatric symptom clusters of Alzheimer's disease in Hong Kong Chinese: prevalence and confirmatory factor analysis of the Neuropsychiatric Inventory.
Int Psychogeriatr. 2012 Sep;24(9):1465-73. doi: 10.1017/S1041610212000609. Epub 2012 Apr 25.
Int Psychogeriatr. 2012.
PMID: 22717370
Free article.
BACKGROUND: The aim of this study was to investigate the clustering of symptoms on the Neuropsychiatric Inventory (NPI) and the relative prevalence of symptom clusters in mild and moderate Alzheimer's disease (AD). METHODS: Confirmatory factor analysis (CFA) …
BACKGROUND: The aim of this study was to investigate the clustering of symptoms on the Neuropsychiatric Inventory (NPI) and the relative …
Clustering of behavioural and psychological symptoms in dementia (BPSD): a European Alzheimer's disease consortium (EADC) study.
Acta Clin Belg. 2007 Nov-Dec;62(6):426-32. doi: 10.1179/acb.2007.062.
Acta Clin Belg. 2007.
PMID: 18351187
METHODS: We recruited 194 patients with dementia from the memory clinic practice of six European Alzheimer's Disease Consortium centres. BPSD were assessed using a pre-designed questionnaire comprising the Neuropsychiatric Inventory (NPI). BPSD scores were an …
METHODS: We recruited 194 patients with dementia from the memory clinic practice of six European Alzheimer's Disease Co …
Neurodegenerative pathologies associated with behavioral and psychological symptoms of dementia in a community-based autopsy cohort.
Acta Neuropathol Commun. 2023 Jun 2;11(1):89. doi: 10.1186/s40478-023-01576-z.
Acta Neuropathol Commun. 2023.
PMID: 37269007
Free PMC article.
In addition to the memory disorders and global cognitive impairment that accompany neurodegenerative diseases, behavioral and psychological symptoms of dementia (BPSD) commonly impair quality of life and complicate clinical management. To investigate clinical-pathol …
In addition to the memory disorders and global cognitive impairment that accompany neurodegenerative diseases, behavioral and psychological …
Relationship between neuropsychiatric symptoms and cognitive functions in patients with cognitive impairment.
Psychogeriatrics. 2021 Sep;21(5):773-782. doi: 10.1111/psyg.12738. Epub 2021 Jul 3.
Psychogeriatrics. 2021.
PMID: 34216181
BACKGROUND: Cognitive decline and neuropsychiatric symptoms (NPS) are main clinical manifestations in Alzheimer disease (AD). It is unclear whether the link between specific NPS and cognitive domains exists in AD or mild cognitive impairment (MCI). ...The ass …
BACKGROUND: Cognitive decline and neuropsychiatric symptoms (NPS) are main clinical manifestations in Alzheimer disease …
Neuropsychiatric symptoms and severity of dementia.
Dement Neuropsychol. 2013 Apr-Jun;7(2):171-175. doi: 10.1590/S1980-57642013DN70200006.
Dement Neuropsychol. 2013.
PMID: 29213836
Free PMC article.
RESULTS: The 124 subjects (mean age of 80.4 7.0 years), 88 women (70.9%) had average duration of dementia of 7.1 3.2 years, most common dementias of Alzheimer's disease (35.5%) and mixed (31.5%) and most prevalent NPS of apathy (75%) and irritabilit …
RESULTS: The 124 subjects (mean age of 80.4 7.0 years), 88 women (70.9%) had average duration of dementia of 7.1 3.2 years, most common deme …
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