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Did you mean the role of a chromosome in alzheimer (806 results)?
The X Files: "The Mystery of X Chromosome Instability in Alzheimer's Disease".
Bajic VP, Essack M, Zivkovic L, Stewart A, Zafirovic S, Bajic VB, Gojobori T, Isenovic E, Spremo-Potparevic B. Bajic VP, et al. Front Genet. 2020 Jan 28;10:1368. doi: 10.3389/fgene.2019.01368. eCollection 2019. Front Genet. 2020. PMID: 32047510 Free PMC article. Review.
Alzheimer's disease (AD) is a neurodegenerative disease that affects millions of individuals worldwide and can occur relatively early or later in life. ...In this review, we examine the role of X chromosome epigenetics and, based u
Alzheimer's disease (AD) is a neurodegenerative disease that affects millions of individuals worldwide and can o
The Role of X Chromosome in Alzheimer's Disease Genetics.
Belloy ME, Guen YL, Stewart I, Herz J, Sherva R, Zhang R, Merritt V, Panizzon MS, Hauger RL; VA Million Veteran Program; Gaziano JM, Logue M, Napolioni V, Greicius MD. Belloy ME, et al. medRxiv [Preprint]. 2024 Apr 23:2024.04.22.24306094. doi: 10.1101/2024.04.22.24306094. medRxiv. 2024. PMID: 38712163 Free PMC article. Preprint.
IMPORTANCE: The X chromosome has remained enigmatic in Alzheimer's disease (AD), yet it makes up 5% of the genome and carries a high proportion of genes expressed in the brain, making it particularly appealing as a potential source of unexplored …
IMPORTANCE: The X chromosome has remained enigmatic in Alzheimer's disease (AD), yet it makes up 5% of th …
The genetic contribution of the X chromosome in age-related hearing loss.
Naderi E, Cornejo-Sanchez DM, Li G, Schrauwen I, Wang GT, Dewan AT, Leal SM. Naderi E, et al. Front Genet. 2023 Feb 21;14:1106328. doi: 10.3389/fgene.2023.1106328. eCollection 2023. Front Genet. 2023. PMID: 36896235 Free PMC article.
We estimated that only a small amount of variation of ARHL, 0.4%, is explained by variants on the X chromosome. This study suggests that although there are likely a few genes contributing to ARHL on the X chromosome, the role that the X
We estimated that only a small amount of variation of ARHL, 0.4%, is explained by variants on the X chromosome. This study sug …
X-Chromosome Association Study in Latin American Cohorts Identifies New Loci in Parkinson's Disease.
Leal TP, Rao SC, French-Kwawu JN, Gouveia MH, Borda V, Bandres-Ciga S, Inca-Martinez M, Mason EA, Horimoto ARVR, Loesch DP, Sarihan EI, Cornejo-Olivas MR, Torres LE, Mazzetti-Soler PE, Cosentino C, Sarapura-Castro EH, Rivera-Valdivia A, Medina AC, Dieguez EM, Raggio VE, Lescano A, Tumas V, Borges V, Ferraz HB, Rieder CR, Schumacher Schuh A, Santos-Lobato BL, Velez-Pardo C, Jimenez-Del-Rio M, Lopera F, Moreno S, Chana-Cuevas P, Fernandez W, Arboleda G, Arboleda H, Arboleda Bustos CE, Yearout D, Barbosa MT, Cardoso FEC, Caramelli P, Cunningham MCQ, Maia DP, Lima-Costa MF, Tarazona-Santos E, Zabetian CP; International Parkinson Disease Genomics Consortium (IPDGC); Thornton TA, O'Connor TD, Mata IF; Latin American Research Consortium on the Genetics of Parkinson's Disease (LARGE-PD). Leal TP, et al. Mov Disord. 2023 Sep;38(9):1625-1635. doi: 10.1002/mds.29508. Epub 2023 Jul 20. Mov Disord. 2023. PMID: 37469269
OBJECTIVE: The objective of this study was to perform the first X-chromosome-wide association study for PD risk in a Latin American cohort. ...We also developed an X-chromosome framework specifically designed for admixed populations. ...
OBJECTIVE: The objective of this study was to perform the first X-chromosome-wide association study for PD risk in a Latin Ame …
X chromosome-wide association study of quantitative biomarkers from the Alzheimer's Disease Neuroimaging Initiative study.
Wang KW, Yuan YX, Zhu B, Zhang Y, Wei YF, Meng FS, Zhang S, Wang JX, Zhou JY; Alzheimer’s Disease Neuroimaging Initiative. Wang KW, et al. Front Aging Neurosci. 2023 Nov 14;15:1277731. doi: 10.3389/fnagi.2023.1277731. eCollection 2023. Front Aging Neurosci. 2023. PMID: 38035272 Free PMC article.
INTRODUCTION: Alzheimer's disease (AD) is a complex neurodegenerative disease with high heritability. ...METHODS: Using the data from the Alzheimer's Disease Neuroimaging Initiative Study, we conducted an X chromosome
INTRODUCTION: Alzheimer's disease (AD) is a complex neurodegenerative disease with high heritability. ...METHODS …
The X-chromosome instability phenotype in Alzheimer's disease: a clinical sign of accelerating aging?
Bajić VP, Spremo-Potparević B, Zivković L, Bonda DJ, Siedlak SL, Casadesus G, Lee HG, Smith MA. Bajić VP, et al. Med Hypotheses. 2009 Dec;73(6):917-20. doi: 10.1016/j.mehy.2009.06.046. Epub 2009 Jul 31. Med Hypotheses. 2009. PMID: 19647374 Free PMC article.
This phenomenon, seen in Robert's syndrome and various cancers, has also been documented in peripheral as well as neuronal cells of Alzheimer's disease (AD). In the latter instances, fluorescent in situ hybridization (FISH), applied to the centromere region o …
This phenomenon, seen in Robert's syndrome and various cancers, has also been documented in peripheral as well as neuronal cells of Alzhe
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.
Kanoni S, Graham SE, Wang Y, Surakka I, Ramdas S, Zhu X, Clarke SL, Bhatti KF, Vedantam S, Winkler TW, Locke AE, Marouli E, Zajac GJM, Wu KH, Ntalla I, Hui Q, Klarin D, Hilliard AT, Wang Z, Xue C, Thorleifsson G, Helgadottir A, Gudbjartsson DF, Holm H, Olafsson I, Hwang MY, Han S, Akiyama M, Sakaue S, Terao C, Kanai M, Zhou W, Brumpton BM, Rasheed H, Havulinna AS, Veturi Y, Pacheco JA, Rosenthal EA, Lingren T, Feng Q, Kullo IJ, Narita A, Takayama J, Martin HC, Hunt KA, Trivedi B, Haessler J, Giulianini F, Bradford Y, Miller JE, Campbell A, Lin K, Millwood IY, Rasheed A, Hindy G, Faul JD, Zhao W, Weir DR, Turman C, Huang H, Graff M, Choudhury A, Sengupta D, Mahajan A, Brown MR, Zhang W, Yu K, Schmidt EM, Pandit A, Gustafsson S, Yin X, Luan J, Zhao JH, Matsuda F, Jang HM, Yoon K, Medina-Gomez C, Pitsillides A, Hottenga JJ, Wood AR, Ji Y, Gao Z, Haworth S, Yousri NA, Mitchell RE, Chai JF, Aadahl M, Bjerregaard AA, Yao J, Manichaikul A, Hwu CM, Hung YJ, Warren HR, Ramirez J, Bork-Jensen J, Kårhus LL, Goel A, Sabater-Lleal M, Noordam R, Mauro P, Matteo F, McDaid AF, Marques-Vidal P, Wielscher M, Trompet S, Sattar N, Møllehave LT, Munz M, Zeng L, Huang J, Yang B, Poveda A, Kurbasic A, L… See abstract for full author list ➔ Kanoni S, et al. Genome Biol. 2022 Dec 27;23(1):268. doi: 10.1186/s13059-022-02837-1. Genome Biol. 2022. PMID: 36575460 Free PMC article.
We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3-5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X
We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3-5% of autosomal lipid-associated loci demonstrate sex-biased ef …
LncRNA Xist, X-chromosome Instability and Alzheimer's Disease.
Chanda K, Mukhopadhyay D. Chanda K, et al. Curr Alzheimer Res. 2020;17(6):499-507. doi: 10.2174/1567205017666200807185624. Curr Alzheimer Res. 2020. PMID: 32851944 Review.
X-inactive Specific Transcript (XIST), a component of the Xic, the X-chromosome inactivation centre, is an RNA gene on the X chromosome of the placental mammals indispensable for the X inactivation process. ...Comprehensive knowledge about how Xist cou …
X-inactive Specific Transcript (XIST), a component of the Xic, the X-chromosome inactivation centre, is an RNA gene on the …
Escape from X-chromosome inactivation and sex differences in Alzheimer's disease.
Song QH, Zhao KX, Huang S, Chen T, He L. Song QH, et al. Rev Neurosci. 2024 Jan 1;35(3):341-354. doi: 10.1515/revneuro-2023-0108. Print 2024 Apr 25. Rev Neurosci. 2024. PMID: 38157427 Review.
The cause of sex differences in Alzheimer's disease remains unclear. Accumulating evidence suggests the potential role of X-linked genetic factors in the sex difference of Alzheimer's disease (AD). ...Based on recent research findi …
The cause of sex differences in Alzheimer's disease remains unclear. Accumulating evidence suggests the potential ro
A second X chromosome contributes to resilience in a mouse model of Alzheimer's disease.
Davis EJ, Broestl L, Abdulai-Saiku S, Worden K, Bonham LW, Miñones-Moyano E, Moreno AJ, Wang D, Chang K, Williams G, Garay BI, Lobach I, Devidze N, Kim D, Anderson-Bergman C, Yu GQ, White CC, Harris JA, Miller BL, Bennett DA, Arnold AP, De Jager PL, Palop JJ, Panning B, Yokoyama JS, Mucke L, Dubal DB. Davis EJ, et al. Sci Transl Med. 2020 Aug 26;12(558):eaaz5677. doi: 10.1126/scitranslmed.aaz5677. Sci Transl Med. 2020. PMID: 32848093 Free PMC article.
A major sex difference in Alzheimer's disease (AD) is that men with the disease die earlier than do women. ...With or without a Y chromosome, hAPP mice with one X chromosome showed worse mortality and deficits than did those with two X ch …
A major sex difference in Alzheimer's disease (AD) is that men with the disease die earlier than do women. ...Wi …
27 results