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The SLC22 family with transporters of organic cations, anions and zwitterions.
Koepsell H. Koepsell H. Mol Aspects Med. 2013 Apr-Jun;34(2-3):413-35. doi: 10.1016/j.mam.2012.10.010. Mol Aspects Med. 2013. PMID: 23506881 Review.
The SLC22 family contains 13 functionally characterized human plasma membrane proteins each with 12 predicted α-helical transmembrane domains. The family comprises organic cation transporters (OCTs), organic zwitte
The SLC22 family contains 13 functionally characterized human plasma membrane proteins each with 12 predicted α- …
Expression and function of organic cation and anion transporters (SLC22 family) in the CNS.
Farthing CA, Sweet DH. Farthing CA, et al. Curr Pharm Des. 2014;20(10):1472-86. doi: 10.2174/13816128113199990456. Curr Pharm Des. 2014. PMID: 23789957 Review.
These barriers are dynamic tissues that accomplish this task by expressing dozens of transporter proteins representing numerous transporter families. One such family, belonging to the Solute Carrier (SLC) superfamily, is the organic ca
These barriers are dynamic tissues that accomplish this task by expressing dozens of transporter proteins representing numerou …
Interaction of Ethambutol with human organic cation transporters of the SLC22 family indicates potential for drug-drug interactions during antituberculosis therapy.
Pan X, Wang L, Gründemann D, Sweet DH. Pan X, et al. Antimicrob Agents Chemother. 2013 Oct;57(10):5053-9. doi: 10.1128/AAC.01255-13. Epub 2013 Aug 5. Antimicrob Agents Chemother. 2013. PMID: 23917312 Free PMC article.
Ethambutol is an organic cation at physiological pH, and its major metabolite, 2,2'-(ethylenediimino)dibutyric acid (EDA), is zwitterionic. Therefore, we assessed the effects of ethambutol and EDA on the function of human organic cation trans
Ethambutol is an organic cation at physiological pH, and its major metabolite, 2,2'-(ethylenediimino)dibutyric acid (EDA), is …
Evolutionary Analysis and Classification of OATs, OCTs, OCTNs, and Other SLC22 Transporters: Structure-Function Implications and Analysis of Sequence Motifs.
Zhu C, Nigam KB, Date RC, Bush KT, Springer SA, Saier MH Jr, Wu W, Nigam SK. Zhu C, et al. PLoS One. 2015 Nov 4;10(11):e0140569. doi: 10.1371/journal.pone.0140569. eCollection 2015. PLoS One. 2015. PMID: 26536134 Free PMC article.
The SLC22 family includes organic anion transporters (OATs), organic cation transporters (OCTs) and organic carnitine and zwitterion transporters (OCTNs). These are often referred to as drug transport
The SLC22 family includes organic anion transporters (OATs), organic cation transporters
SLC22, SLC44, and SLC47 transporters--organic anion and cation transporters: molecular and cellular properties.
Pelis RM, Wright SH. Pelis RM, et al. Curr Top Membr. 2014;73:233-61. doi: 10.1016/B978-0-12-800223-0.00006-2. Curr Top Membr. 2014. PMID: 24745985 Review.
Transporters within the SLC22, SLC44, and SLC47 families of solute carriers mediate transport of a structurally diverse array of organic electrolytes, that is, molecules that are generally charged (cationic, anionic, or zwitteri
Transporters within the SLC22, SLC44, and SLC47 families of solute carriers mediate transport of a structurally
Profiling SLCO and SLC22 genes in the NCI-60 cancer cell lines to identify drug uptake transporters.
Okabe M, Szakács G, Reimers MA, Suzuki T, Hall MD, Abe T, Weinstein JN, Gottesman MM. Okabe M, et al. Mol Cancer Ther. 2008 Sep;7(9):3081-91. doi: 10.1158/1535-7163.MCT-08-0539. Mol Cancer Ther. 2008. PMID: 18790787 Free PMC article.
Using quantitative real-time PCR, we measured the mRNA expression of two solute carrier (SLC) families, the organic cation/zwitterion transporters (SLC22 family) and the organic anion transporters (SLCO fami
Using quantitative real-time PCR, we measured the mRNA expression of two solute carrier (SLC) families, the organic cation
The SLC22 drug transporter family.
Koepsell H, Endou H. Koepsell H, et al. Pflugers Arch. 2004 Feb;447(5):666-76. doi: 10.1007/s00424-003-1089-9. Epub 2003 Jul 19. Pflugers Arch. 2004. PMID: 12883891 Review.
The SLC22 family comprises organic cation transporters (OCTs), zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). ...Transporters of the SLC22 family func …
The SLC22 family comprises organic cation transporters (OCTs), zwitterion/cation transpo
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