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The SLC22 family with transporters of organic cations, anions and zwitterions.
Koepsell H. Koepsell H. Mol Aspects Med. 2013 Apr-Jun;34(2-3):413-35. doi: 10.1016/j.mam.2012.10.010. Mol Aspects Med. 2013. PMID: 23506881 Review.
The SLC22 family contains 13 functionally characterized human plasma membrane proteins each with 12 predicted alpha-helical transmembrane domains. The family comprises organic cation transporters (OCTs), organic zw …
The SLC22 family contains 13 functionally characterized human plasma membrane proteins each with 12 predicted al …
Expression and function of organic cation and anion transporters (SLC22 family) in the CNS.
Farthing CA, Sweet DH. Farthing CA, et al. Curr Pharm Des. 2014;20(10):1472-86. doi: 10.2174/13816128113199990456. Curr Pharm Des. 2014. PMID: 23789957 Review.
A major function of the blood brain barrier (BBB) and blood cerebrospinal fluid barrier (BCSFB) is to exert selective control over the flux of organic cations and anions into and out of the CNS compartment. These barriers are dynamic tissues that accomplish t …
A major function of the blood brain barrier (BBB) and blood cerebrospinal fluid barrier (BCSFB) is to exert selective control over the flux …
Emerging Roles of the Human Solute Carrier 22 Family.
Yee SW, Giacomini KM. Yee SW, et al. Drug Metab Dispos. 2021 Dec 17;50(9):1193-210. doi: 10.1124/dmd.121.000702. Drug Metab Dispos. 2021. PMID: 34921098 Free PMC article.
The human Solute Carrier 22 family (SLC22), also termed the organic ion transporter family, consists of 28 distinct multi-membrane spanning proteins, which phylogenetically cluster together according to their charge specificity for …
The human Solute Carrier 22 family (SLC22), also termed the organic ion transporter family, consists of 2 …
SLC22, SLC44, and SLC47 transporters--organic anion and cation transporters: molecular and cellular properties.
Pelis RM, Wright SH. Pelis RM, et al. Curr Top Membr. 2014;73:233-61. doi: 10.1016/B978-0-12-800223-0.00006-2. Curr Top Membr. 2014. PMID: 24745985 Review.
Transporters within the SLC22, SLC44, and SLC47 families of solute carriers mediate transport of a structurally diverse array of organic electrolytes, that is, molecules that are generally charged (cationic, anionic, or zwitteri …
Transporters within the SLC22, SLC44, and SLC47 families of solute carriers mediate transport of a structurally …
Interaction of Ethambutol with human organic cation transporters of the SLC22 family indicates potential for drug-drug interactions during antituberculosis therapy.
Pan X, Wang L, Gründemann D, Sweet DH. Pan X, et al. Antimicrob Agents Chemother. 2013 Oct;57(10):5053-9. doi: 10.1128/AAC.01255-13. Epub 2013 Aug 5. Antimicrob Agents Chemother. 2013. PMID: 23917312 Free PMC article.
Ethambutol is considered a first-line antituberculosis drug. Ethambutol is an organic cation at physiological pH, and its major metabolite, 2,2'-(ethylenediimino)dibutyric acid (EDA), is zwitterionic. Therefore, we assessed the effects of ethambutol and EDA o …
Ethambutol is considered a first-line antituberculosis drug. Ethambutol is an organic cation at physiological pH, and its majo …
The SLC22 drug transporter family.
Koepsell H, Endou H. Koepsell H, et al. Pflugers Arch. 2004 Feb;447(5):666-76. doi: 10.1007/s00424-003-1089-9. Epub 2003 Jul 19. Pflugers Arch. 2004. PMID: 12883891 Review.
The SLC22 family comprises organic cation transporters (OCTs), zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). ...Transporters of the SLC22 family func …
The SLC22 family comprises organic cation transporters (OCTs), zwitterion/cation transpo …
Organic Cation Transporter Expression and Function in the CNS.
Sweet DH. Sweet DH. Handb Exp Pharmacol. 2021;266:41-80. doi: 10.1007/164_2021_463. Handb Exp Pharmacol. 2021. PMID: 33963461
To fulfill their roles, these barriers and cell types express a multitude of transporter proteins from dozens of different transporter families. Fundamental advances over the past few decades in our knowledge of transporter substrates, expressio …
To fulfill their roles, these barriers and cell types express a multitude of transporter proteins from dozens of different …
Evolutionary Analysis and Classification of OATs, OCTs, OCTNs, and Other SLC22 Transporters: Structure-Function Implications and Analysis of Sequence Motifs.
Zhu C, Nigam KB, Date RC, Bush KT, Springer SA, Saier MH Jr, Wu W, Nigam SK. Zhu C, et al. PLoS One. 2015 Nov 4;10(11):e0140569. doi: 10.1371/journal.pone.0140569. eCollection 2015. PLoS One. 2015. PMID: 26536134 Free PMC article.
The SLC22 family includes organic anion transporters (OATs), organic cation transporters (OCTs) and organic carnitine and zwitterion transporters (OCTNs). ...Phylogenetic analysis of SLC22 support …
The SLC22 family includes organic anion transporters (OATs), organic cation transporters …
Profiling SLCO and SLC22 genes in the NCI-60 cancer cell lines to identify drug uptake transporters.
Okabe M, Szakács G, Reimers MA, Suzuki T, Hall MD, Abe T, Weinstein JN, Gottesman MM. Okabe M, et al. Mol Cancer Ther. 2008 Sep;7(9):3081-91. doi: 10.1158/1535-7163.MCT-08-0539. Mol Cancer Ther. 2008. PMID: 18790787 Free PMC article.
Using quantitative real-time PCR, we measured the mRNA expression of two solute carrier (SLC) families, the organic cation/zwitterion transporters (SLC22 family) and the organic anion transporters (SLCO fami …
Using quantitative real-time PCR, we measured the mRNA expression of two solute carrier (SLC) families, the organic cation …
OCTN1 (SLC22A4) displays two different transport pathways for organic cations or zwitterions.
Pochini L, Barone F, Console L, Brunocilla C, Galluccio M, Scalise M, Indiveri C. Pochini L, et al. Biochim Biophys Acta Biomembr. 2024 Feb;1866(2):184263. doi: 10.1016/j.bbamem.2023.184263. Epub 2023 Dec 12. Biochim Biophys Acta Biomembr. 2024. PMID: 38092232 Free article.
BACKGROUND: OCTN1 belongs to the SLC22 family, which includes transporters for cationic, zwitterionic, and anionic substrates. OCTN1 function and role in cells are still poorly understood. Not only cations, such as TEA, but also …
BACKGROUND: OCTN1 belongs to the SLC22 family, which includes transporters for cationic, zwitterionic, an …