Structural insight into the binding mechanism of ATP to EGFR and L858R, and T790M and L858R/T790 mutants.
J Biomol Struct Dyn. 2019 Oct;37(17):4671-4684. doi: 10.1080/07391102.2018.1558112. Epub 2019 Jan 11.
J Biomol Struct Dyn. 2019.
PMID: 30558477
Although this resistance was initially attributed to steric blocking by the T790M mutation, experimental studies have demonstrated that differences in the binding affinities of TKIs to T790M and L858R/T790M mutants are more a result of the increased se …
Although this resistance was initially attributed to steric blocking by the T790M mutation, experimental studies have demonstr …