Structural insight into the binding mechanism of ATP to EGFR and L858R, and T790M and L858R/T790 mutants.
Saldaña-Rivera L, Bello M, Méndez-Luna D.
Saldaña-Rivera L, et al.
J Biomol Struct Dyn. 2019 Oct;37(17):4671-4684. doi: 10.1080/07391102.2018.1558112. Epub 2019 Jan 11.
J Biomol Struct Dyn. 2019.
PMID: 30558477
This efficacy decreases due to drug resistance conferred by a second mutation, T790M, which subsequently produces a double mutant, L858R/T790M. ...Regrettably, detailed information at the atomic level on the origins of the increased binding affinity …
This efficacy decreases due to drug resistance conferred by a second mutation, T790M, which subsequently produces a dou …