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The bHLH transcription factor Olig2 promotes oligodendrocyte differentiation in collaboration with Nkx2.2.
Zhou Q, Choi G, Anderson DJ. Zhou Q, et al. Neuron. 2001 Sep 13;31(5):791-807. doi: 10.1016/s0896-6273(01)00414-7. Neuron. 2001. PMID: 11567617 Free article.
Olig2, a basic helix-loop-helix (bHLH) transcription factor, is expressed in a restricted domain of the spinal cord ventricular zone that sequentially generates motoneurons and oligodendrocytes. ...Coexpression of
Olig2, a basic helix-loop-helix (bHLH) transcription factor, is expressed in a restr
Ascl1 is required for oligodendrocyte development in the spinal cord.
Sugimori M, Nagao M, Parras CM, Nakatani H, Lebel M, Guillemot F, Nakafuku M. Sugimori M, et al. Development. 2008 Apr;135(7):1271-81. doi: 10.1242/dev.015370. Epub 2008 Feb 20. Development. 2008. PMID: 18287202 Free article.
Gain-of-function studies further showed that Ascl1 collaborates with Olig2 and Nkx2-2 in promoting differentiation of OLPs into oligodendrocytes in vitro. Overexpression of Ascl1, Olig2 and Nkx2-2 alone stimula …
Gain-of-function studies further showed that Ascl1 collaborates with Olig2 and Nkx2-2 in promoting dif
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