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2020 0
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The effect of genetic variation in PCSK9 on the LDL-cholesterol response to statin therapy.
Feng Q, Wei WQ, Chung CP, Levinson RT, Bastarache L, Denny JC, Stein CM. Feng Q, et al. Pharmacogenomics J. 2017 Mar;17(2):204-208. doi: 10.1038/tpj.2016.3. Epub 2016 Feb 23. Pharmacogenomics J. 2017. PMID: 26902539 Free PMC article.
Statins (HMG-CoA reductase inhibitors) lower low-density lipoprotein cholesterol (LDL-C) and prevent cardiovascular disease. ...The therapeutic effect of statins may be modified by genetic variation in PCSK9
Statins (HMG-CoA reductase inhibitors) lower low-density lipoprotein cholesterol (LDL-C) and preve
The effect of APOE, CETP, and PCSK9 polymorphisms on simvastatin response in Thai hypercholesterolemic patients.
Wanmasae S, Sirintronsopon W, Porntadavity S, Jeenduang N. Wanmasae S, et al. Cardiovasc Ther. 2017 Dec;35(6). doi: 10.1111/1755-5922.12302. Epub 2017 Sep 25. Cardiovasc Ther. 2017. PMID: 28851085 Free article.
AIM: To investigate the effect of apolipoprotein E (APOE), cholesteryl ester transfer protein (CETP) and proprotein convertase subtilisin kexin type 9 (PCSK9) polymorphisms on the lipid-lowering response to simvastatin therapy in Thai hypercholesterole …
AIM: To investigate the effect of apolipoprotein E (APOE), cholesteryl ester transfer protein (CETP) and proprotein convertase subtil …
Resistance and intolerance to statins.
Reiner Z. Reiner Z. Nutr Metab Cardiovasc Dis. 2014 Oct;24(10):1057-66. doi: 10.1016/j.numecd.2014.05.009. Epub 2014 Jun 6. Nutr Metab Cardiovasc Dis. 2014. PMID: 24996502 Review.
BACKGROUND AND AIMS: Many patients treated with statins are considered statin-resistant because they fail to achieve adequate reduction of low density lipoprotein cholesterol (LDL-C) levels. ...Patients with inflammatory states and HIV infection also h …
BACKGROUND AND AIMS: Many patients treated with statins are considered statin-resistant because they fail to achieve adequate …
Homozygous Familial Hypercholesterolemia Patients With Identical Mutations Variably Express the LDLR (Low-Density Lipoprotein Receptor): Implications for the Efficacy of Evolocumab.
Thedrez A, Blom DJ, Ramin-Mangata S, Blanchard V, Croyal M, Chemello K, Nativel B, Pichelin M, Cariou B, Bourane S, Tang L, Farnier M, Raal FJ, Lambert G. Thedrez A, et al. Arterioscler Thromb Vasc Biol. 2018 Mar;38(3):592-598. doi: 10.1161/ATVBAHA.117.310217. Epub 2017 Dec 28. Arterioscler Thromb Vasc Biol. 2018. PMID: 29284604 Free PMC article. Clinical Trial.
However, their individual responses are highly variable, even among carriers of identical LDLR genetic defects. We aimed to elucidate why HoFH patients variably respond to PCSK9 inhibition. APPROACH AND RESULTS: Lymphocytes were isolated from 22 HoFH patients …
However, their individual responses are highly variable, even among carriers of identical LDLR genetic defects. We aimed to el …
Effect of ezetimibe coadministered with statins in genotype-confirmed heterozygous FH patients.
Pisciotta L, Fasano T, Bellocchio A, Bocchi L, Sallo R, Fresa R, Colangeli I, Cantafora A, Calandra S, Bertolini S. Pisciotta L, et al. Atherosclerosis. 2007 Oct;194(2):e116-22. doi: 10.1016/j.atherosclerosis.2006.10.036. Epub 2006 Nov 30. Atherosclerosis. 2007. PMID: 17140581 Clinical Trial.
PCSK9 and NPC1L1 genes were analysed to assess the role of genetic variants in response to therapy. In FH patients combined therapy reduced LDL-C by 57%, irrespective of the type of LDLR mutation. ...The variable response to sta
PCSK9 and NPC1L1 genes were analysed to assess the role of genetic variants in response to therapy. In FH patien
Targeting the proprotein convertase subtilisin/kexin type 9 for the treatment of dyslipidemia and atherosclerosis.
Urban D, Pöss J, Böhm M, Laufs U. Urban D, et al. J Am Coll Cardiol. 2013 Oct 15;62(16):1401-8. doi: 10.1016/j.jacc.2013.07.056. Epub 2013 Aug 21. J Am Coll Cardiol. 2013. PMID: 23973703 Free article. Review.
Low intracellular cholesterol levels in response to statin treatment activate the sterol regulatory element-binding protein-2 (SREBP-2), resulting in coexpression of LDLR and PCSK9. Although this self-regulatory mechanism contributes to maintain cho
Low intracellular cholesterol levels in response to statin treatment activate the sterol regulatory element-binding pro …
Leucine 10 allelic variant in signal peptide of PCSK9 increases the LDL cholesterol-lowering effect of statins in patients with familial hypercholesterolaemia.
Pisciotta L, Sallo R, Rabacchi C, Wunsch A, Calandra S, Bertolini S. Pisciotta L, et al. Nutr Metab Cardiovasc Dis. 2012 Oct;22(10):831-5. doi: 10.1016/j.numecd.2011.04.003. Epub 2011 Sep 14. Nutr Metab Cardiovasc Dis. 2012. PMID: 21920719
We investigated the effect of L10 variant on basal lipid profile and response to statins in molecularly characterised FH patients. ...CONCLUSION: The variant L10 of the leucine repeats in PCSK9 signal peptide is to be considered as a factor capable of …
We investigated the effect of L10 variant on basal lipid profile and response to statins in molecularly characterised F …
Missense mutations in the PCSK9 gene are associated with hypocholesterolemia and possibly increased response to statin therapy.
Berge KE, Ose L, Leren TP. Berge KE, et al. Arterioscler Thromb Vasc Biol. 2006 May;26(5):1094-100. doi: 10.1161/01.ATV.0000204337.81286.1c. Epub 2006 Jan 19. Arterioscler Thromb Vasc Biol. 2006. PMID: 16424354
Also, the cholesterol-lowering effect of statins could be increased in subjects carrying mutations in the PCSK9 gene. METHODS AND RESULTS: We have screened 38 unrelated hypocholesterolemic subjects as well as 25 unrelated familial hypercholesterolemia …
Also, the cholesterol-lowering effect of statins could be increased in subjects carrying mutations in the PCSK9
Genetic variation at the PCSK9 locus moderately lowers low-density lipoprotein cholesterol levels, but does not significantly lower vascular disease risk in an elderly population.
Polisecki E, Peter I, Robertson M, McMahon AD, Ford I, Packard C, Shepherd J, Jukema JW, Blauw GJ, Westendorp RG, de Craen AJ, Trompet S, Buckley BM, Murphy MB, Ordovas JM, Schaefer EJ; PROSPER Study Group. Polisecki E, et al. Atherosclerosis. 2008 Sep;200(1):95-101. doi: 10.1016/j.atherosclerosis.2007.12.005. Epub 2008 Feb 8. Atherosclerosis. 2008. PMID: 18262190 Free PMC article. Clinical Trial.
Caucasian carriers of the T allele at R46L in the proprotein convertase subtilisin/kexin type 9 (PCSK9) locus have been reported to have 15% lower low-density lipoprotein (LDL) cholesterol (C) levels and 47% lower coronary heart disease (CHD) risk. ...In this …
Caucasian carriers of the T allele at R46L in the proprotein convertase subtilisin/kexin type 9 (PCSK9) locus have been reported to h …
Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors: Present perspectives and future horizons.
Yadav K, Sharma M, Ferdinand KC. Yadav K, et al. Nutr Metab Cardiovasc Dis. 2016 Oct;26(10):853-62. doi: 10.1016/j.numecd.2016.05.006. Epub 2016 May 30. Nutr Metab Cardiovasc Dis. 2016. PMID: 27352986 Review.
Statin intolerance is a common clinical concern affecting adherence and the benefit with statins. There is also significant variation of individual lipid-lowering. ...Statin use has multiplied since the validation of LDL hypothesis, however, it
Statin intolerance is a common clinical concern affecting adherence and the benefit with statins. There is also significant
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