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2019 4
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The gut microbiota--masters of host development and physiology.
Sommer F, Bäckhed F. Sommer F, et al. Nat Rev Microbiol. 2013 Apr;11(4):227-38. doi: 10.1038/nrmicro2974. Epub 2013 Feb 25. Nat Rev Microbiol. 2013. PMID: 23435359 Review.
Establishing and maintaining beneficial interactions between the host and its associated microbiota are key requirements for host health. Although the gut microbiota has previously been studied in the context of inflammatory diseases, it has rec …
Establishing and maintaining beneficial interactions between the host and its associated microbiota are key requirements for …
The Dynamic Interplay between the Gut Microbiota and Autoimmune Diseases.
Xu H, Liu M, Cao J, Li X, Fan D, Xia Y, Lu X, Li J, Ju D, Zhao H. Xu H, et al. J Immunol Res. 2019 Oct 27;2019:7546047. doi: 10.1155/2019/7546047. eCollection 2019. J Immunol Res. 2019. PMID: 31772949 Free PMC article. Review.
Aryl hydrocarbon receptor, a ligand-activated transcription factor, is a master moderator of host-microbiota interactions because it shapes the immune system and impacts host metabolism. In addition, treatment optimization while minimizing potential ad …
Aryl hydrocarbon receptor, a ligand-activated transcription factor, is a master moderator of host-microbiota interactio …
A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment.
Van Hove H, Martens L, Scheyltjens I, De Vlaminck K, Pombo Antunes AR, De Prijck S, Vandamme N, De Schepper S, Van Isterdael G, Scott CL, Aerts J, Berx G, Boeckxstaens GE, Vandenbroucke RE, Vereecke L, Moechars D, Guilliams M, Van Ginderachter JA, Saeys Y, Movahedi K. Van Hove H, et al. Nat Neurosci. 2019 Jun;22(6):1021-1035. doi: 10.1038/s41593-019-0393-4. Epub 2019 May 6. Nat Neurosci. 2019. PMID: 31061494
Finally, gene network analysis and conditional deletion revealed IRF8 as a master regulator that drives the maturation and diversity of brain macrophages. Our results provide a framework for understanding host-macrophage interactions in both the healthy and diseased …
Finally, gene network analysis and conditional deletion revealed IRF8 as a master regulator that drives the maturation and diversity …
The impact of age and gut microbiota on Th17 and Tfh cells in K/BxN autoimmune arthritis.
Teng F, Felix KM, Bradley CP, Naskar D, Ma H, Raslan WA, Wu HJ. Teng F, et al. Arthritis Res Ther. 2017 Aug 15;19(1):188. doi: 10.1186/s13075-017-1398-6. Arthritis Res Ther. 2017. PMID: 28810929 Free PMC article.
Gut microbiota are known to be involved in the pathogenesis of RA, but the effects of microbiota in older subjects remain mostly unknown. ...Our results also indicate that exposure to immunomodulatory commensals may allow the young host to develop
Gut microbiota are known to be involved in the pathogenesis of RA, but the effects of microbiota in older subjects rema
Chemoproteomic Profiling of Gut Microbiota-Associated Bile Salt Hydrolase Activity.
Parasar B, Zhou H, Xiao X, Shi Q, Brito IL, Chang PV. Parasar B, et al. ACS Cent Sci. 2019 May 22;5(5):867-873. doi: 10.1021/acscentsci.9b00147. Epub 2019 Apr 18. ACS Cent Sci. 2019. PMID: 31139722 Free PMC article.
Here, we developed chemoproteomic tools to profile changes in gut microbiome-associated BSH activity. ...Importantly, our findings reveal that alterations in BSH enzymatic activities within the gut microbiome do not correlate with changes in gen …
Here, we developed chemoproteomic tools to profile changes in gut microbiome-associated BSH activity. ...Importantly, o …
Cross-talk between type 3 innate lymphoid cells and the gut microbiota in inflammatory bowel disease.
Buela KA, Omenetti S, Pizarro TT. Buela KA, et al. Curr Opin Gastroenterol. 2015 Nov;31(6):449-55. doi: 10.1097/MOG.0000000000000217. Curr Opin Gastroenterol. 2015. PMID: 26398682 Free PMC article. Review.
PURPOSE OF REVIEW: Innate lymphoid cells (ILCs) are a newly-identified population of immune cells prevalent in, but not limited to, mucosal tissues that not only play a significant role in immune homeostasis and host defense, but also in disease pathogenesis. This review h …
PURPOSE OF REVIEW: Innate lymphoid cells (ILCs) are a newly-identified population of immune cells prevalent in, but not limited to, mucosal …
Inflammatory bowel diseases: interrelationships between dietary vitamin D, exposure to UV radiation and the fecal microbiome.
Ghaly S, Hart PH, Lawrance IC. Ghaly S, et al. Expert Rev Gastroenterol Hepatol. 2019 Nov;13(11):1039-1048. doi: 10.1080/17474124.2019.1685874. Epub 2019 Nov 7. Expert Rev Gastroenterol Hepatol. 2019. PMID: 31657973
Vitamin D and ultraviolet radiation (UVR) are environmental factors that are associated by several pathways, including changes to the gastrointestinal microbiome, with the development and course of IBD.Area covered: This review explores the interaction of vit …
Vitamin D and ultraviolet radiation (UVR) are environmental factors that are associated by several pathways, including changes to the gas