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The idiopathic intracranial hypertension treatment trial: clinical profile at baseline.
Wall M, Kupersmith MJ, Kieburtz KD, Corbett JJ, Feldon SE, Friedman DI, Katz DM, Keltner JL, Schron EB, McDermott MP; NORDIC Idiopathic Intracranial Hypertension Study Group. Wall M, et al. JAMA Neurol. 2014 Jun;71(6):693-701. doi: 10.1001/jamaneurol.2014.133. JAMA Neurol. 2014. PMID: 24756302 Free PMC article. Clinical Trial.
IMPORTANCE: To our knowledge, there are no large prospective cohorts of untreated patients with idiopathic intracranial hypertension (IIH) to characterize the disease. OBJECTIVE: To report the baseline clinical and laboratory features of patient …
IMPORTANCE: To our knowledge, there are no large prospective cohorts of untreated patients with idiopathic intracranial hyp …
Nuclear Magnetic Resonance Spectroscopy Metabolomics in Idiopathic Intracranial Hypertension to Identify Markers of Disease and Headache.
Grech O, Seneviratne SY, Alimajstorovic Z, Yiangou A, Mitchell JL, Smith TB, Mollan SP, Lavery GG, Ludwig C, Sinclair AJ. Grech O, et al. Neurology. 2022 Oct 17;99(16):e1702-e1714. doi: 10.1212/WNL.0000000000201007. Neurology. 2022. PMID: 36240084 Free PMC article.
BACKGROUND AND OBJECTIVE: We evaluated the metabolomic profile in the CSF, serum, and urine of participants with idiopathic intracranial hypertension (IIH) compared with that in controls and measured changes in metabolism associated with clinical …
BACKGROUND AND OBJECTIVE: We evaluated the metabolomic profile in the CSF, serum, and urine of participants with idiopathic …
Safety and Efficacy of Metformin for Idiopathic Intracranial Hypertension. A U.S-Based Real-World Data Retrospective Multicenter Cohort Study.
Azzam AY, Nassar M, Zomia ASA, Elswedy A, Morsy MM, Mohamed AA, Elamin O, Elsayed OS, Azab MA, Essibayi MA, Wu J, Dmytirw AA, Altschul DJ. Azzam AY, et al. ASIDE Intern Med. 2025;1(1):12-19. doi: 10.71079/2024001001. Epub 2024 Dec 28. ASIDE Intern Med. 2025. PMID: 39816946 Free PMC article.
INTRODUCTION: Managing idiopathic intracranial hypertension (IIH) is challenging due to limited treatment options. ...This suggests complex mechanisms at play, supporting further research through prospective clinical trials to confirm met …
INTRODUCTION: Managing idiopathic intracranial hypertension (IIH) is challenging due to limited treatment option …
A randomized sequential cross-over trial evaluating five purportedly ICP-lowering drugs in idiopathic intracranial hypertension.
Mitchell JL, Lyons HS, Walker JK, Yiangou A, Thaller M, Grech O, Alimajstorovic Z, Tsermoulas G, Brock K, Mollan SP, Sinclair AJ. Mitchell JL, et al. Headache. 2025 Feb;65(2):258-268. doi: 10.1111/head.14897. Epub 2025 Jan 24. Headache. 2025. PMID: 39853738 Free PMC article. Clinical Trial.
OBJECTIVE: To gain initial insight into the efficacy to lower intracranial pressure (ICP), side effects, and effects on cognition of five drugs commonly used to treat idiopathic intracranial hypertension (IIH). ...Cognitive measures were impaired by ac …
OBJECTIVE: To gain initial insight into the efficacy to lower intracranial pressure (ICP), side effects, and effects on cognition of …
Safety and Efficacy of Metformin for Idiopathic Intracranial Hypertension. A U.S-Based Real-World Data Retrospective Multicenter Cohort Study.
Azzam AY, Nassar M, Al Zomia AS, Elswedy A, Morsy MM, Mohamed AA, Elamin O, Elsayed OS, Azab MA, Essibayi MA, Wu J, Dmytirw AA, Altschul DJ. Azzam AY, et al. medRxiv [Preprint]. 2024 Oct 7:2024.09.01.24312907. doi: 10.1101/2024.09.01.24312907. medRxiv. 2024. Update in: ASIDE Intern Med. 2025;1(1):12-19. doi: 10.71079/2024001001. PMID: 39410963 Free PMC article. Updated. Preprint.
INTRODUCTION: Idiopathic intracranial hypertension (IIH) remains a challenging condition to manage, with limited therapeutic options. ...These findings warrant further investigation through prospective clinical trials to establish metformin's ro …
INTRODUCTION: Idiopathic intracranial hypertension (IIH) remains a challenging condition to manage, with limited therap …
Identifying MicroRNA Biomarkers in Idiopathic Intracranial Hypertension: A Pilot Study.
Hill LJ, Begum G, Thomas CN, Hubbard JC, Mugo C, Alimajstorovic Z, Botfield HF, Lyons HS, Thaller M, Yiangou A, Ludwig C, Grech O, Mitchell JL, Mollan SP, Sinclair AJ. Hill LJ, et al. Neurology. 2026 Jul 14;107(1):e218162. doi: 10.1212/WNL.0000000000218162. Epub 2026 Jun 17. Neurology. 2026. PMID: 42308437 Free PMC article. Clinical Trial.
BACKGROUND AND OBJECTIVES: Idiopathic intracranial hypertension (IIH) is characterized by raised intracranial pressure (ICP). ...CLASSIFICATION OF EVIDENCE: This study provides Class III evidence that serum microRNA markers may potentially distinguish …
BACKGROUND AND OBJECTIVES: Idiopathic intracranial hypertension (IIH) is characterized by raised intracranial pr …
Bromocriptine for Idiopathic Intracranial Hypertension: A Retrospective Multicenter Cohort Study.
Morsy MM, Azzam AY, Mirdad MT, Abadi AM, Alqahtani SAM, Abukhadijah HJ, Elamin O, Morsy MD, Altschul DJ. Morsy MM, et al. Int J Gen Med. 2025 Apr 4;18:1933-1943. doi: 10.2147/IJGM.S512250. eCollection 2025. Int J Gen Med. 2025. PMID: 40201930 Free PMC article.
INTRODUCTION: Idiopathic Intracranial Hypertension (IIH) is a disorder characterized by elevated intracranial pressure without an identifiable cause, commonly affecting young obese women. ...CONCLUSION: Bromocriptine shows promise as an effective and s …
INTRODUCTION: Idiopathic Intracranial Hypertension (IIH) is a disorder characterized by elevated intracranial pr …
Pharmacokinetics of IGF-1 in PAPP-A2-Deficient Patients, Growth Response, and Effects on Glucose and Bone Density.
Cabrera-Salcedo C, Mizuno T, Tyzinski L, Andrew M, Vinks AA, Frystyk J, Wasserman H, Gordon CM, Hwa V, Backeljauw P, Dauber A. Cabrera-Salcedo C, et al. J Clin Endocrinol Metab. 2017 Dec 1;102(12):4568-4577. doi: 10.1210/jc.2017-01411. J Clin Endocrinol Metab. 2017. PMID: 29029190 Free PMC article. Clinical Trial.
The two younger siblings were started on rhIGF-1 treatment. An oral glucose tolerance test and dual-energy X-ray absorptiometry scans were obtained at baseline and after 1 year of treatment. ...Treatment with rhIGF-1 is ongoing in the youngest patient …
The two younger siblings were started on rhIGF-1 treatment. An oral glucose tolerance test and dual-energy X-ray absorptiometry scans …