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2019 1
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The impact of mitotic errors on cell proliferation and tumorigenesis.
Levine MS, Holland AJ. Levine MS, et al. Genes Dev. 2018 May 1;32(9-10):620-638. doi: 10.1101/gad.314351.118. Genes Dev. 2018. PMID: 29802124 Free PMC article. Review.
Here, we review the sources of mitotic errors in human tumors and their effect on cell fitness and transformation. We discuss new findings that suggest that chromosome missegregation can produce a proinflammatory environment and impact tumor responsive …
Here, we review the sources of mitotic errors in human tumors and their effect on cell fitness and transformation. We d …
Risks of aneuploidy induction from chemical exposure: Twenty years of collaborative research in Europe from basic science to regulatory implications.
Kirsch-Volders M, Pacchierotti F, Parry EM, Russo A, Eichenlaub-Ritter U, Adler ID. Kirsch-Volders M, et al. Mutat Res Rev Mutat Res. 2019 Jan-Mar;779:126-147. doi: 10.1016/j.mrrev.2018.11.002. Epub 2018 Dec 27. Mutat Res Rev Mutat Res. 2019. PMID: 31097149 Review.
Although Theodor Boveri linked abnormal chromosome numbers and disease more than a century ago, an in-depth understanding of the impact of mitotic and meiotic chromosome segregation errors on cell proliferation and diseases is still lacking. ... …
Although Theodor Boveri linked abnormal chromosome numbers and disease more than a century ago, an in-depth understanding of the impact
Systemic Chromosome Instability Resulted in Colonic Transcriptomic Changes in Metabolic, Proliferation, and Stem Cell Regulators in Sgo1-/+ Mice.
Rao CV, Sanghera S, Zhang Y, Biddick L, Reddy A, Lightfoot S, Janakiram NB, Mohammed A, Dai W, Yamada HY. Rao CV, et al. Cancer Res. 2016 Feb 1;76(3):630-42. doi: 10.1158/0008-5472.CAN-15-0940. Cancer Res. 2016. PMID: 26833665 Free PMC article.
Chromosome instability (CIN) is observed in 80% to 90% of colon cancers and is thought to contribute to colon cancer progression and recurrence. To investigate the impact of CIN on colon cancer development, we developed shugoshin-1 (Sgo1) haploinsufficient (-/+) mice, an a …
Chromosome instability (CIN) is observed in 80% to 90% of colon cancers and is thought to contribute to colon cancer progression and recurre …