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The impact of osteoblastic differentiation on osteosarcomagenesis in the mouse.
Quist T, Jin H, Zhu JF, Smith-Fry K, Capecchi MR, Jones KB. Quist T, et al. Oncogene. 2015 Aug 6;34(32):4278-84. doi: 10.1038/onc.2014.354. Epub 2014 Oct 27. Oncogene. 2015. PMID: 25347737 Free PMC article.
In order to test how the cell of origin contributes to the final state of differentiation in the transformed cells, we compared the relative tumorigenicity of Cre-LoxP conditional disruption of the cell cycle checkpoint tumor-suppressor genes Trp53 and Rb1 us …
In order to test how the cell of origin contributes to the final state of differentiation in the transformed cells, we compare …
PTEN Plays Dual Roles As a Tumor Suppressor in Osteosarcoma Cells.
Xi Y, Chen Y. Xi Y, et al. J Cell Biochem. 2017 Sep;118(9):2684-2692. doi: 10.1002/jcb.25888. Epub 2017 Apr 25. J Cell Biochem. 2017. PMID: 28106296
The downregulation of PTEN also associates with activation of AKT pathway. We then treated previously reported mouse OS tumor cells MOTO-Rank(delta/deltaOC) and human OS cell line U2OS with PTEN inhibitor VO-OHpic to investigate how PTEN impacts tumor cell …
The downregulation of PTEN also associates with activation of AKT pathway. We then treated previously reported mouse OS tumor cells M …