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The intra- and extracellular functions of ASC specks.
Franklin BS, Latz E, Schmidt FI. Franklin BS, et al. Immunol Rev. 2018 Jan;281(1):74-87. doi: 10.1111/imr.12611. Immunol Rev. 2018. PMID: 29247990 Review.
On the molecular level, this is accomplished by the sensor-nucleated recruitment and oligomerization of the adapter protein ASC. Once a tunable threshold is reached, cooperative assembly of ASC into linear filaments and their condensation into macromolecular ASC
On the molecular level, this is accomplished by the sensor-nucleated recruitment and oligomerization of the adapter protein ASC. Once …
Unknown/enigmatic functions of extracellular ASC.
de Souza JG, Starobinas N, Ibañez OCM. de Souza JG, et al. Immunology. 2021 Aug;163(4):377-388. doi: 10.1111/imm.13375. Epub 2021 Jun 22. Immunology. 2021. PMID: 34042182 Free PMC article. Review.
Apoptosis-associated speck-like protein containing a caspase recruit domain (ASC), encoded by PYCARD gene, is a 22 kDa small molecule, which aggregates into ASC specks during inflammasome activation. ASC protein is an adaptor protein present in …
Apoptosis-associated speck-like protein containing a caspase recruit domain (ASC), encoded by PYCARD gene, is a 22 kDa small m …