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Points-to-consider on the return of results in epigenetic research.
Dyke SOM, Saulnier KM, Dupras C, Webster AP, Maschke K, Rothstein M, Siebert R, Walter J, Beck S, Pastinen T, Joly Y. Dyke SOM, et al. Genome Med. 2019 May 23;11(1):31. doi: 10.1186/s13073-019-0646-6. Genome Med. 2019. PMID: 31122281 Free PMC article. Review.
Members of the International Human Epigenome Consortium (IHEC) Bioethics Workgroup considered the potential ethical, legal, and social issues (ELSI) involved in returning epigenetic research results and incidental findings in order to produce a set of …
Members of the International Human Epigenome Consortium (IHEC) Bioethics Workgroup considered the potential ethical, legal, and socia …
The legal risks of returning results of genomics research.
Clayton EW, McGuire AL. Clayton EW, et al. Genet Med. 2012 Apr;14(4):473-7. doi: 10.1038/gim.2012.10. Epub 2012 Feb 9. Genet Med. 2012. PMID: 22323070 Free PMC article.
Although some have argued against the return of results in research, many cite an emerging consensus that there is an ethical obligation to return at least some results; the debate quickly turns to issues of mechanics (e.g., which results …
Although some have argued against the return of results in research, many cite an emerging consensus that there is an e …
Returning Results to Family Members: Professional Duties in Genomics Research in the United States.
Fox D, Spencer E, Torkamani A. Fox D, et al. J Leg Med. 2018 Apr-Jun;38(2):201-219. doi: 10.1080/01947648.2017.1417934. J Leg Med. 2018. PMID: 30289737
This article critically appraises the ethical and legal duties to disclose findings to the family members of research participants. ...Research laboratories should generally be immune from liability for failing to diagnose or disclose a genetic disorder in ti …
This article critically appraises the ethical and legal duties to disclose findings to the family members of research particip …
Ethical challenges of precision cancer medicine.
Winkler EC, Knoppers BM. Winkler EC, et al. Semin Cancer Biol. 2022 Sep;84:263-270. doi: 10.1016/j.semcancer.2020.09.009. Epub 2020 Oct 9. Semin Cancer Biol. 2022. PMID: 33045356 Review.
With the advent of genomic sequencing technologies, achieving precision cancer medicine requires prospective norms due to the large and varied sources of data involved. Here, we discuss the ethical and legal aspects of the policy debate around the relevant topics in precis …
With the advent of genomic sequencing technologies, achieving precision cancer medicine requires prospective norms due to the large and vari …
Toward the implementation of genomic applications for smoking cessation and smoking-related diseases.
Ramsey AT, Chen LS, Hartz SM, Saccone NL, Fisher SL, Proctor EK, Bierut LJ. Ramsey AT, et al. Transl Behav Med. 2018 Jan 29;8(1):7-17. doi: 10.1093/tbm/ibx060. Transl Behav Med. 2018. PMID: 29385591 Free PMC article. Review.
Our review identified at least three specific genomic applications for which implementation may be considered, including the use of CHRNA5 genetic test results for informing disease risk, optimizing smoking cessation treatment, and motivating smoking behavior change …
Our review identified at least three specific genomic applications for which implementation may be considered, including the use of CHRNA5 g …
Ethical, legal and social implications of human genome studies in radiation research: a workshop report for studies on atomic bomb survivors at the Radiation Effects Research Foundation.
Noda A, Kato K, Tamura C, Biesecker LG, Imaizumi M, Inoue Y, Henderson GE, Wilfond B, Muto K, Naito M, Kayukawa J. Noda A, et al. J Radiat Res. 2021 Jul 10;62(4):656-661. doi: 10.1093/jrr/rrab043. J Radiat Res. 2021. PMID: 34059901 Free PMC article.
In December 2020, RERF held a virtual international workshop on the ethical, legal and social implications (ELSI) of genome studies. In this workshop, the ELSI considerations of future human genome studies on radiation research including atomic bomb survivors and th …
In December 2020, RERF held a virtual international workshop on the ethical, legal and social implications (ELSI) of genome studies. …
An Examination of the Ethical and Legal Limits in Implementing "Traceback Testing" for Deceased Patients.
Martucci J, Prado Y, Rope AF, Weinmann S, White L, Zepp J, Henrikson NB, Feigelson HS, Hunter JE, Lee SS. Martucci J, et al. J Law Med Ethics. 2022;50(4):818-832. doi: 10.1017/jme.2023.23. J Law Med Ethics. 2022. PMID: 36883408 Free PMC article.
This paper examines the legal and ethical aspects of traceback testing, a process in which patients who have been previously diagnosed with ovarian cancer are identified and offered genetic testing so that their family members can be informed of their genetic risk a …
This paper examines the legal and ethical aspects of traceback testing, a process in which patients who have been previously diagnose …
An Ethics Checklist for Digital Health Research in Psychiatry: Viewpoint.
Shen FX, Silverman BC, Monette P, Kimble S, Rauch SL, Baker JT. Shen FX, et al. J Med Internet Res. 2022 Feb 9;24(2):e31146. doi: 10.2196/31146. J Med Internet Res. 2022. PMID: 35138261 Free PMC article.
We convened an interdisciplinary expert stakeholder workshop in May 2020, and this checklist emerges out of that dialogue. RESULTS: Consistent with recent ELSI analyses, we find that existing ethical guidance and legal regulations are not sufficient for deep phenoty …
We convened an interdisciplinary expert stakeholder workshop in May 2020, and this checklist emerges out of that dialogue. RESULTS: C …
Exploring access to genomic risk information and the contours of the HIPAA public health exception.
Wagner JK, Tanniru JK, Chane CA, Meyer MN. Wagner JK, et al. J Law Biosci. 2022 Dec 10;9(2):lsac034. doi: 10.1093/jlb/lsac034. eCollection 2022 Jul-Dec. J Law Biosci. 2022. PMID: 36518815 Free PMC article.
Considerable resources have been invested in research to identify pathogenic and likely pathogenic variants that cause morbidity and mortality and also in returning these results to patients. ...We conclude by reflecting on ethical considerations of leveragin …
Considerable resources have been invested in research to identify pathogenic and likely pathogenic variants that cause morbidity and …
Classification of painful or painless diabetic peripheral neuropathy and identification of the most powerful predictors using machine learning models in large cross-sectional cohorts.
Baskozos G, Themistocleous AC, Hebert HL, Pascal MMV, John J, Callaghan BC, Laycock H, Granovsky Y, Crombez G, Yarnitsky D, Rice ASC, Smith BH, Bennett DLH. Baskozos G, et al. BMC Med Inform Decis Mak. 2022 May 29;22(1):144. doi: 10.1186/s12911-022-01890-x. BMC Med Inform Decis Mak. 2022. PMID: 35644620 Free PMC article.
Model selection was carried out using the Mathews Correlation Coefficient (MCC) and model performance was quantified in the validation set using MCC, the area under the precision/recall curve (AUPRC) and accuracy. RESULTS: Random Forest (MCC = 0.28, AUPRC = 0.76) and Adapt …
Model selection was carried out using the Mathews Correlation Coefficient (MCC) and model performance was quantified in the validation set u …
21 results