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The phenotypic legacy of admixture between modern humans and Neandertals.
Simonti CN, Vernot B, Bastarache L, Bottinger E, Carrell DS, Chisholm RL, Crosslin DR, Hebbring SJ, Jarvik GP, Kullo IJ, Li R, Pathak J, Ritchie MD, Roden DM, Verma SS, Tromp G, Prato JD, Bush WS, Akey JM, Denny JC, Capra JA. Simonti CN, et al. Science. 2016 Feb 12;351(6274):737-41. doi: 10.1126/science.aad2149. Science. 2016. PMID: 26912863 Free PMC article.
Many modern human genomes retain DNA inherited from interbreeding with archaic hominins, such as Neandertals, yet the influence of this admixture on human traits is largely unknown. ...Our results establish that archaic admixture influenc …
Many modern human genomes retain DNA inherited from interbreeding with archaic hominins, such as Neandertals, yet the i …
Something old, something borrowed: admixture and adaptation in human evolution.
Dannemann M, Racimo F. Dannemann M, et al. Curr Opin Genet Dev. 2018 Dec;53:1-8. doi: 10.1016/j.gde.2018.05.009. Epub 2018 Jun 9. Curr Opin Genet Dev. 2018. PMID: 29894925 Review.
The sequencing of ancient DNA from archaic humans-Neanderthals and Denisovans-has revealed that modern and archaic humans interbred at least twice during the Pleistocene. ...What exactly did modern humans obtain from interbreeding with …
The sequencing of ancient DNA from archaic humans-Neanderthals and Denisovans-has revealed that modern and archaic h …
The Population-Specific Impact of Neandertal Introgression on Human Disease.
Dannemann M. Dannemann M. Genome Biol Evol. 2021 Jan 7;13(1):evaa250. doi: 10.1093/gbe/evaa250. Genome Biol Evol. 2021. PMID: 33247712 Free PMC article.
Since the discovery of admixture between modern humans and Neandertals, multiple studies investigated the effect of Neandertal-derived DNA on human disease and nondisease phenotypes. ...Many of these disease associations are linked …
Since the discovery of admixture between modern humans and Neandertals, multiple studies investigated the effect …
Neanderthal-Derived Genetic Variation is Associated with Functional Connectivity in the Brains of Living Humans.
Gregory MD, Kippenhan JS, Kohn P, Eisenberg DP, Callicott JH, Kolachana B, Berman KF. Gregory MD, et al. Brain Connect. 2021 Feb;11(1):38-44. doi: 10.1089/brain.2020.0809. Epub 2020 Dec 29. Brain Connect. 2021. PMID: 33218283 Free PMC article.
Aim: To determine whether Neanderthal-derived genetic variation relates to functional connectivity patterns in the brains of living modern humans. Introduction: Nearly 50,000 years ago, Neanderthals interbred with ancestors of modern humans, imp …
Aim: To determine whether Neanderthal-derived genetic variation relates to functional connectivity patterns in the brains of living moder …
Human Stem Cell Resources Are an Inroad to Neandertal DNA Functions.
Dannemann M, He Z, Heide C, Vernot B, Sidow L, Kanton S, Weigert A, Treutlein B, Pääbo S, Kelso J, Camp JG. Dannemann M, et al. Stem Cell Reports. 2020 Jul 14;15(1):214-225. doi: 10.1016/j.stemcr.2020.05.018. Epub 2020 Jun 18. Stem Cell Reports. 2020. PMID: 32559457 Free PMC article.
A portion of this variation originates from an ancient admixture between modern humans and Neandertals, which introduced alleles that left a phenotypic legacy on individual humans today. ...We also show that transcriptomic data fro …
A portion of this variation originates from an ancient admixture between modern humans and Neandertals, which in …