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The role of proteomics in assessing beta-cell dysfunction and death in type 1 diabetes.
Nakayasu ES, Qian WJ, Evans-Molina C, Mirmira RG, Eizirik DL, Metz TO. Nakayasu ES, et al. Expert Rev Proteomics. 2019 Jul;16(7):569-582. doi: 10.1080/14789450.2019.1634548. Epub 2019 Jun 24. Expert Rev Proteomics. 2019. PMID: 31232620 Free PMC article.
Introduction: Type 1 diabetes (T1D) is characterized by autoimmune-induced dysfunction and destruction of the pancreatic beta cells. ...Areas covered: Mass spectrometry (MS)-based proteomics and complementary techniques play an imp …
Introduction: Type 1 diabetes (T1D) is characterized by autoimmune-induced dysfunction and destruction of the pa …
PTPN2 Regulates the Interferon Signaling and Endoplasmic Reticulum Stress Response in Pancreatic β-Cells in Autoimmune Diabetes.
Elvira B, Vandenbempt V, Bauzá-Martinez J, Crutzen R, Negueruela J, Ibrahim H, Winder ML, Brahma MK, Vekeriotaite B, Martens PJ, Singh SP, Rossello F, Lybaert P, Otonkoski T, Gysemans C, Wu W, Gurzov EN. Elvira B, et al. Diabetes. 2022 Apr 1;71(4):653-668. doi: 10.2337/db21-0443. Diabetes. 2022. PMID: 35044456
Type 1 diabetes (T1D) results from autoimmune destruction of beta-cells in the pancreas. Protein tyrosine phosphatases (PTPs) are candidate genes for T1D and play a key role in autoimmune disease development and beta-cell
Type 1 diabetes (T1D) results from autoimmune destruction of beta-cells in the pancreas. Protein tyrosine