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The chemokines CCL5 and CXCL12 exhibit high-affinity binding to N-terminal peptides of the non-cognate receptors CXCR4 and CCR5, respectively.
Kessler N, Akabayov SR, Cohen LS, Scherf T, Naider F, Anglister J. Kessler N, et al. FEBS J. 2024 Feb;291(3):458-476. doi: 10.1111/febs.17013. Epub 2023 Dec 1. FEBS J. 2024. PMID: 37997026
CC and CXC chemokines are distinct chemokine subfamilies. CC chemokines usually do not bind CXC-chemokine receptors and vice versa. ...CCL5 contains one conserved binding site for a sulfated tyrosine residue, whereas CXCL12 is unique in having two addi …
CC and CXC chemokines are distinct chemokine subfamilies. CC chemokines usually do not bind CXC-chemokine receptors and vice v …
Effects of Small Molecule Ligands on ACKR3 Receptors.
Hopkins BE, Masuho I, Ren D, Iyamu ID, Lv W, Malik N, Martemyanov KA, Schiltz GE, Miller RJ. Hopkins BE, et al. Mol Pharmacol. 2022 Sep;102(3):128-138. doi: 10.1124/molpharm.121.000295. Epub 2022 Jul 9. Mol Pharmacol. 2022. PMID: 35809897 Free PMC article.
Chemokines such as stromal derived factor 1 and their G protein coupled receptors are well-known regulators of the development and functions of numerous tissues. C-X-C motif chemokine ligand 12 (CXCL12) has two receptors: C-X-C chemokine motif r …
Chemokines such as stromal derived factor 1 and their G protein coupled receptors are well-known regulators of the development and …
Patient-Derived Bone Marrow Spheroids Reveal Leukemia-Initiating Cells Supported by Mesenchymal Hypoxic Niches in Pediatric B-ALL.
Balandrán JC, Dávila-Velderrain J, Sandoval-Cabrera A, Zamora-Herrera G, Terán-Cerqueda V, García-Stivalet LA, Limón-Flores JA, Armenta-Castro E, Rodríguez-Martínez A, Leon-Chavez BA, Vallejo-Ruiz V, Hassane DC, Pérez-Tapia SM, Ortiz-Navarrete V, Guzman ML, Pelayo R. Balandrán JC, et al. Front Immunol. 2021 Oct 19;12:746492. doi: 10.3389/fimmu.2021.746492. eCollection 2021. Front Immunol. 2021. PMID: 34737747 Free PMC article.
Importantly, transcriptional profiles of MSC derived from primary patient samples revealed two unique signatures (1), a CXCL12(low) inflammatory and leukemia expansion (ILE)-like niche, that likely supports leukemic burden, and (2) a CXCL11(hi) immune-suppressive an …
Importantly, transcriptional profiles of MSC derived from primary patient samples revealed two unique signatures (1), a CXCL12 …