Therapeutic anti-tumor immunity triggered by injections of immunostimulating single-stranded RNA.
Eur J Immunol. 2006.
PMID: 17013976
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Multifunctional oncolytic nanoparticles deliver self-replicating IL-12 RNA to eliminate established tumors and prime systemic immunity.
Nat Cancer. 2020 Sep;1(9):882-893. doi: 10.1038/s43018-020-0095-6. Epub 2020 Aug 10.
Nat Cancer. 2020.
PMID: 34447945
Free PMC article.
Therapies that synergistically stimulate immunogenic cancer cell death (ICD), inflammation, and immune priming are of great interest for cancer immunotherapy. However, even multi-agent therapies often fail to trigger all of the steps necessary for self-sustaining …
Therapies that synergistically stimulate immunogenic cancer cell death (ICD), inflammation, and immune priming are of great interest …
Therapeutic anti-tumor immunity triggered by injections of immunostimulating single-stranded RNA.
Eur J Immunol. 2006 Oct;36(10):2807-16. doi: 10.1002/eji.200635910.
Eur J Immunol. 2006.
PMID: 17013976
Free article.
We wanted to find out whether this danger signal is capable of triggering anti-tumor immunity when injected locally into an established tumor. Using the mouse glioma tumor cell line SMA-560 in syngenic VM/Dk mice, we were able to show that intra …
We wanted to find out whether this danger signal is capable of triggering anti-tumor immunity when injected …
Intratumoral delivery of the chitin-derived C100 adjuvant promotes robust STING, IFNAR, and CD8(+) T cell-dependent anti-tumor immunity.
Cell Rep Med. 2024 May 21;5(5):101560. doi: 10.1016/j.xcrm.2024.101560. Epub 2024 May 9.
Cell Rep Med. 2024.
PMID: 38729159
Free PMC article.
Here, we identify C100, a highly deacetylated chitin-derived polymer (HDCP), as an attractive alternative to conventional STING agonists. C100 promotes potent anti-tumor immune responses, outperforming less deacetylated HDCPs, with therapeutic efficacy …
Here, we identify C100, a highly deacetylated chitin-derived polymer (HDCP), as an attractive alternative to conventional STING agonists. C1 …
Anti-tumor immunity elicited by direct intratumoral administration of a recombinant adenovirus expressing either IL-28A/IFN-lambda2 or IL-29/IFN-lambda1.
Cancer Gene Ther. 2016 Aug;23(8):266-77. doi: 10.1038/cgt.2016.29. Epub 2016 Aug 19.
Cancer Gene Ther. 2016.
PMID: 27561689
Interleukin (IL)-28A/interferon (IFN)-lambda2 and IL-29/IFN-lambda1 have been demonstrated to elicit direct and indirect anti-tumor actions. In this study, we constructed an adenovirus vector expressing either IL-28A/IFN-lambda2 (AdIL-28A) or IL-29/IFN-lambda1 (AdIL …
Interleukin (IL)-28A/interferon (IFN)-lambda2 and IL-29/IFN-lambda1 have been demonstrated to elicit direct and indirect anti-tumo …
Prevention of Tumor Growth and Dissemination by In Situ Vaccination with Mitochondria-Targeted Atovaquone.
Adv Sci (Weinh). 2022 Apr;9(12):e2101267. doi: 10.1002/advs.202101267. Epub 2022 Mar 4.
Adv Sci (Weinh). 2022.
PMID: 35243806
Free PMC article.
A recently synthesized mitochondria-targeted atovaquone increased mitochondrial accumulation and antitumor activity in vitro. Using an in situ vaccination approach, local injection of mitochondria-targeted atovaquone into primary tumors triggered potent T cel …
A recently synthesized mitochondria-targeted atovaquone increased mitochondrial accumulation and antitumor activity in vitro. Using an in si …
In situ chemoimmunotherapy hydrogel elicits immunogenic cell death and evokes efficient antitumor immune response.
J Transl Med. 2024 Apr 9;22(1):341. doi: 10.1186/s12967-024-05102-0.
J Transl Med. 2024.
PMID: 38594751
Free PMC article.
BACKGROUND: Chemoimmunotherapy has shown promising advantages of eliciting immunogenic cell death and activating anti-tumor immune responses. However, the systemic toxicity of chemotherapy and tumor immunosuppressive microenvironment limit the clinical applic …
BACKGROUND: Chemoimmunotherapy has shown promising advantages of eliciting immunogenic cell death and activating anti-tumor …
Generation of potent anti-tumor immunity in mice by interleukin-12-secreting dendritic cells.
Cancer Immunol Immunother. 2005 Jan;54(1):67-77. doi: 10.1007/s00262-004-0571-3.
Cancer Immunol Immunother. 2005.
PMID: 15693141
Free PMC article.
This anti-tumor immune response was most pronounced when using recombinant protein as an antigen source, which was evident in a prophylactic as well as in a therapeutic setting. The absence of a response to parental K-Balb tumors confirmed the antigen …
This anti-tumor immune response was most pronounced when using recombinant protein as an antigen source, which was evid …
Screening and mechanistic study of natural compounds that enhance T cell anti-tumor effects post-heat treatment.
Front Immunol. 2025 Mar 27;16:1537398. doi: 10.3389/fimmu.2025.1537398. eCollection 2025.
Front Immunol. 2025.
PMID: 40213558
Free PMC article.
By triggering the generation of heat shock proteins and facilitating mitochondrial energy supply, the 39C treatment amplified the anti-tumor functions of T cells. ...High-throughput transcriptomics studies disclosed that the combination of thermotherapy and T …
By triggering the generation of heat shock proteins and facilitating mitochondrial energy supply, the 39C treatment amplified the …
Electrical Stimulation for Immune Modulation in Cancer Treatments.
Front Bioeng Biotechnol. 2022 Jan 11;9:795300. doi: 10.3389/fbioe.2021.795300. eCollection 2021.
Front Bioeng Biotechnol. 2022.
PMID: 35087799
Free PMC article.
Review.
Several therapies utilize electroporation to deliver immunostimulants (like genes encoded with cytokine producing sequences, cancer specific antigens or fragments of anti-tumor toxins) more effectively. Lastly, electrical stimulation of the vagus nerve can …
Several therapies utilize electroporation to deliver immunostimulants (like genes encoded with cytokine producing sequences, cancer s …
Silver nanoparticles induce a non-immunogenic tumor cell death.
J Immunotoxicol. 2023 Dec;20(1):2175078. doi: 10.1080/1547691X.2023.2175078.
J Immunotoxicol. 2023.
PMID: 36773297
Free article.
Consequently, anti-tumoral prophylactic immunization with AgNP-dead cells failed to protect mice from tumor re-challenge; intra-tumor injection of AgNP did not induce a significant effect. ...Clearly, further research is needed to determine if one could combine AgNP …
Consequently, anti-tumoral prophylactic immunization with AgNP-dead cells failed to protect mice from tumor re-challenge; intra-tumor …
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