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Beta-Blockers after Myocardial Infarction in Patients without Heart Failure.
Munkhaugen J, Kristensen AMD, Halvorsen S, Holmager T, Olsen MH, Bakken A, Sehested TSG, Ruddox V, Mæng M, Vikenes K, Jensen SE, Steigen T, Lambrechtsen J, Jortveit J, Bovin A, Schirmer H, Christiansen MK, Wiseth R, Mikkelsen D, Larsen AI, Lyngby Kjærgaard C, Andresen K, Gustafsson I, Tuseth V, Larsen ML, Deeg PS, Veien K, Bøhmer E, Bøtker HE, Brattrud AO, Brønnum-Schou J, Pettersen AR, Bang LE, Øie E, Engstrøm T, Borg EB, Kristensen K, Nymo SH, Gislason G, Vethe NT, Abdulla JAM, Dammen T, Mouridsen MR, Bendz B, Bertelsen MLN, Hove JD, Schierbeck L, Snoer M, Davidsen C, Egholm G, Thomsen KK, Jadou G, Poenaru M, Krarup NT, Böttcher M, Stæhr PB, Zwisler AD, Edvardsen T, Torp-Pedersen C, Otterstad JE, Lange T, Fagerland MW, Atar D, Prescott E; BETAMI–DANBLOCK Investigators. Munkhaugen J, et al. Among authors: holmager t. N Engl J Med. 2025 Nov 13;393(19):1901-1911. doi: 10.1056/NEJMoa2505985. Epub 2025 Aug 30. N Engl J Med. 2025. PMID: 40888716 Free article. Clinical Trial.
The primary end point was a composite of death from any cause or major adverse cardiovascular events (new myocardial infarction, unplanned coronary revascularization, ischemic stroke, heart failure, or malignant ventricular arrhythmias). ...CONCLUSIONS: Among patients with …
The primary end point was a composite of death from any cause or major adverse cardiovascular events (new myocardial infarction, unpl …
Beta-Blockers after Myocardial Infarction with Normal Ejection Fraction.
Kristensen AMD, Rossello X, Atar D, Yndigegn T, Kimura T, Latini R, Lindahl B, Halvorsen S, Olsen MH, Fuster V, Hofmann R, Vikenes K, Maeng M, Erlinge D, Pocock S, Karlström P, Bakken A, Lange T, Barrabés JA, Benatar J, Raposeiras-Roubin S, Held C, Piepoli M, Fagerland MW, Holmager T, Ozasa N, Prescott EIB, Munkhaugen J, Jernberg T, Ibanez B; Beta-Blocker Trialists’ Collaboration Study Group. Kristensen AMD, et al. Among authors: holmager t. N Engl J Med. 2026 Feb 5;394(6):540-550. doi: 10.1056/NEJMoa2512686. Epub 2025 Nov 9. N Engl J Med. 2026. PMID: 41211954
β blockers after myocardial infarction with mildly reduced ejection fraction: an individual patient data meta-analysis of randomised controlled trials.
Rossello X, Prescott EIB, Kristensen AMD, Latini R, Fuster V, Fagerland MW, Pocock SJ, Halvorsen S, Dominguez-Rodriguez A, Holmager TLF, Sanchez PL, Bakken A, Raposeiras-Roubin S, Jensen SE, Kimura T, Ottani F, Lambrechtsen J, Anguita M, Ozasa N, Atar D, Ibanez B, Munkhaugen J. Rossello X, et al. Among authors: holmager tlf. Lancet. 2025 Sep 13;406(10508):1128-1137. doi: 10.1016/S0140-6736(25)01592-2. Epub 2025 Aug 30. Lancet. 2025. PMID: 40897190
Validating National Registry Data for Randomised Trials: Comparison of registry-derived cardiovascular events with and without adjudication in the BETAMI-DANBLOCK trial.
Holmager TLF, Kristensen AMD, Fagerland MW, Atar D, Olsen MH, Bakken A, Munkhaugen J, Prescott E. Holmager TLF, et al. Eur Heart J Qual Care Clin Outcomes. 2026 Apr 4:qcag055. doi: 10.1093/ehjqcco/qcag055. Online ahead of print. Eur Heart J Qual Care Clin Outcomes. 2026. PMID: 41934630
However, adjudication substantially reduced the number of cardiovascular endpoint events and event-specific misclassification appeared, particularly during the first months after the index-event....
However, adjudication substantially reduced the number of cardiovascular endpoint events and event-specific misclassification appeare …
Temporal trends in cause-specific mortality in a rural-provincial area of Denmark, Lolland-Falster, 1970-2018.
Holmager TLF, Nymand Lophaven S, Mortensen LH, Lynge E. Holmager TLF, et al. Scand J Public Health. 2023 Aug;51(6):853-861. doi: 10.1177/14034948221075023. Epub 2022 Feb 9. Scand J Public Health. 2023. PMID: 35139716 Free PMC article.
METHODS: We used data from Danish registers to calculate cause-specific mortality for 1970-1979, 1980-1989, 1990-1999, 2000-2009 and 2010-2018 divided into cancer, cardiovascular diseases, respiratory diseases, external causes and other causes (all remaining causes). ...Ov …
METHODS: We used data from Danish registers to calculate cause-specific mortality for 1970-1979, 1980-1989, 1990-1999, 2000-2009 and 2010-20 …
Outcomes in the BETAMI-DANBLOCK trial compared with a Norwegian nationwide myocardial infarction population.
Kristensen AMD, Jortveit J, Holmager T, Atar D, Olsen MH, Bakken A, Steigen T, Schirmer H, Edvardsen T, Larsen AI, Otterstad JE, Prescott E, Munkhaugen J, Halvorsen S. Kristensen AMD, et al. Among authors: holmager t. Eur Heart J. 2026 May 25:ehag348. doi: 10.1093/eurheartj/ehag348. Online ahead of print. Eur Heart J. 2026. PMID: 42183826
BACKGROUND AND AIMS: In patients with myocardial infarction (MI), no heart failure, and left ventricular ejection fraction (LVEF) 40%, the combined BETAMI-DANBLOCK trial showed that beta-blockers reduced the risk of all-cause mortality or major adverse cardiovascular eve …
BACKGROUND AND AIMS: In patients with myocardial infarction (MI), no heart failure, and left ventricular ejection fraction (LVEF) 40%, the …