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Cholesterol modification of hedgehog is required for trafficking and movement, revealing an asymmetric cellular response to hedgehog.
Gallet A, Rodriguez R, Ruel L, Therond PP. Gallet A, et al. Among authors: therond pp. Dev Cell. 2003 Feb;4(2):191-204. doi: 10.1016/s1534-5807(03)00031-5. Dev Cell. 2003. PMID: 12586063
Dynamic phosphorylation of the kinesin Costal-2 in vivo reveals requirement of fused kinase activity for all levels of hedgehog signalling.
Raisin S, Ruel L, Ranieri N, Staccini-Lavenant L, Thérond PP. Raisin S, et al. Among authors: therond pp. Dev Biol. 2010 Aug 1;344(1):119-28. doi: 10.1016/j.ydbio.2010.04.021. Epub 2010 May 9. Dev Biol. 2010. PMID: 20435030 Free article.
Cubitus interruptus-independent transduction of the Hedgehog signal in Drosophila.
Gallet A, Angelats C, Kerridge S, Thérond PP. Gallet A, et al. Among authors: therond pp. Development. 2000 Dec;127(24):5509-22. Development. 2000. PMID: 11076770
Differential requirements of the fused kinase for hedgehog signalling in the Drosophila embryo.
Thérond PP, Limbourg Bouchon B, Gallet A, Dussilol F, Pietri T, van den Heuvel M, Tricoire H. Thérond PP, et al. Development. 1999 Sep;126(18):4039-51. Development. 1999. PMID: 10457013
Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2.
Robbins DJ, Nybakken KE, Kobayashi R, Sisson JC, Bishop JM, Thérond PP. Robbins DJ, et al. Among authors: therond pp. Cell. 1997 Jul 25;90(2):225-34. doi: 10.1016/s0092-8674(00)80331-1. Cell. 1997. PMID: 9244297
A genome-wide RNAi screen identifies regulators of cholesterol-modified hedgehog secretion in Drosophila.
Aikin R, Cervantes A, D'Angelo G, Ruel L, Lacas-Gervais S, Schaub S, Thérond P. Aikin R, et al. PLoS One. 2012;7(3):e33665. doi: 10.1371/journal.pone.0033665. Epub 2012 Mar 14. PLoS One. 2012. PMID: 22432040 Free PMC article.
The cis-Golgi Drosophila GMAP has a role in anterograde transport and Golgi organization in vivo, similar to its mammalian ortholog in tissue culture cells.
Friggi-Grelin F, Rabouille C, Therond P. Friggi-Grelin F, et al. Eur J Cell Biol. 2006 Nov;85(11):1155-66. doi: 10.1016/j.ejcb.2006.07.001. Epub 2006 Aug 9. Eur J Cell Biol. 2006. PMID: 16904228
Human receptors patched and smoothened partially transduce hedgehog signal when expressed in Drosophila cells.
De Rivoyre M, Ruel L, Varjosalo M, Loubat A, Bidet M, Thérond P, Mus-Veteau I. De Rivoyre M, et al. J Biol Chem. 2006 Sep 29;281(39):28584-95. doi: 10.1074/jbc.M512986200. Epub 2006 Jul 25. J Biol Chem. 2006. PMID: 16867986
Human receptor Smoothened, a mediator of Hedgehog signalling, expressed in its native conformation in yeast.
De Rivoyre M, Bonino F, Ruel L, Bidet M, Thérond P, Mus-Veteau I. De Rivoyre M, et al. FEBS Lett. 2005 Feb 28;579(6):1529-33. doi: 10.1016/j.febslet.2005.01.054. FEBS Lett. 2005. PMID: 15733868
Cubitus interruptus acts to specify naked cuticle in the trunk of Drosophila embryos.
Angelats C, Gallet A, Thérond P, Fasano L, Kerridge S. Angelats C, et al. Dev Biol. 2002 Jan 1;241(1):132-44. doi: 10.1006/dbio.2001.0498. Dev Biol. 2002. PMID: 11784100
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