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2013 7
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2016 4
2018 2
2022 0
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Thiamine and dystonia 16.
Costantini A, Trevi E, Pala MI, Fancellu R. Costantini A, et al. BMJ Case Rep. 2016 Jul 22;2016:bcr-2016-216721. doi: 10.1136/bcr-2016-216721. BMJ Case Rep. 2016. PMID: 27448549 Free PMC article.
In this study, 3 brothers affected by inherited primary dystonia 16 (DYT16) began an oral therapy with high-dose thiamine from November to December 2015. After 3 months, an important improvement of the motor symptoms was observed. Our results support the hypothesis that pa …
In this study, 3 brothers affected by inherited primary dystonia 16 (DYT16) began an oral therapy with high-dose thiamine from Novemb …
Oral High-Dose Thiamine Improves the Symptoms of Chronic Cluster Headache.
Antonio C, Massimo T, Gianpaolo Z, Immacolata PM, Erika T. Antonio C, et al. Case Rep Neurol Med. 2018 Apr 18;2018:3901619. doi: 10.1155/2018/3901619. eCollection 2018. Case Rep Neurol Med. 2018. PMID: 29850313 Free PMC article.
Some authors have found in patients affected by this disease abnormality in glucose metabolism. Considering the role of thiamine in brain function, in energetic metabolism, and in pain modulation, we treated a patient affected by cluster headache with oral high-dose thi …
Some authors have found in patients affected by this disease abnormality in glucose metabolism. Considering the role of thiamine in b …
High-dose thiamine and essential tremor.
Costantini A. Costantini A. BMJ Case Rep. 2018 Mar 30;2018:bcr2017223945. doi: 10.1136/bcr-2017-223945. BMJ Case Rep. 2018. PMID: 29602891 Free PMC article.
These drugs, however, are often not effective in reducing tremor and cause side effects in a large share of the patients treated. The treatment with intramuscular high-dose thiamine has led to a rapid, remarkable and persistent improvement of the symptoms in two patients w …
These drugs, however, are often not effective in reducing tremor and cause side effects in a large share of the patients treated. The treatm …
Thiamine and fatigue in inflammatory bowel diseases: an open-label pilot study.
Costantini A, Pala MI. Costantini A, et al. J Altern Complement Med. 2013 Aug;19(8):704-8. doi: 10.1089/acm.2011.0840. Epub 2013 Feb 4. J Altern Complement Med. 2013. PMID: 23379830
Fatigue was measured using the chronic fatigue syndrome scale, and the determination of thiamine and thiamine pyrophosphate levels in the blood was carried out through blood tests. The levels of thiamine and thiamine pyrophosphate in the blood were nor …
Fatigue was measured using the chronic fatigue syndrome scale, and the determination of thiamine and thiamine pyrophosphate le …
Long-term treatment with thiamine as possible medical therapy for Friedreich ataxia.
Costantini A, Laureti T, Pala MI, Colangeli M, Cavalieri S, Pozzi E, Brusco A, Salvarani S, Serrati C, Fancellu R. Costantini A, et al. J Neurol. 2016 Nov;263(11):2170-2178. doi: 10.1007/s00415-016-8244-7. Epub 2016 Aug 3. J Neurol. 2016. PMID: 27488863 Free article.
Previous studies reported low thiamine levels in cerebrospinal fluid and pyruvate dehydrogenase dysfunction in Friedreich ataxia (FRDA). ...Further studies are mandatory to evaluate thiamine role on FXN regulation, to exclude placebo effect, to verify our clinical r …
Previous studies reported low thiamine levels in cerebrospinal fluid and pyruvate dehydrogenase dysfunction in Friedreich ataxia (FRD …
Thiamine and Hashimoto's thyroiditis: a report of three cases.
Costantini A, Pala MI. Costantini A, et al. J Altern Complement Med. 2014 Mar;20(3):208-11. doi: 10.1089/acm.2012.0612. Epub 2013 Sep 25. J Altern Complement Med. 2014. PMID: 24351023
Fatigue was measured using the Fatigue Severity Scale. Free thiamine in the serum and thiamine pyrophosphate in red cells were tested before and after the therapy. ...CONCLUSION: As the administration of thiamine led to a partial or complete regression of the …
Fatigue was measured using the Fatigue Severity Scale. Free thiamine in the serum and thiamine pyrophosphate in red cells were …
Thiamine and spinocerebellar ataxia type 2.
Costantini A, Pala MI, Colangeli M, Savelli S. Costantini A, et al. BMJ Case Rep. 2013 Jan 10;2013:bcr2012007302. doi: 10.1136/bcr-2012-007302. BMJ Case Rep. 2013. PMID: 23314445 Free PMC article.
We performed the Scale for Assessment and Rating of Ataxia and Robertson Profile for Dysarthria (Italian version). Thiamine and thiamine pyrophosphate levels in the blood were within the healthy reference range. ...After about 3 months, a discreet improvement of mot …
We performed the Scale for Assessment and Rating of Ataxia and Robertson Profile for Dysarthria (Italian version). Thiamine and th …
High-dose thiamine as initial treatment for Parkinson's disease.
Costantini A, Pala MI, Compagnoni L, Colangeli M. Costantini A, et al. BMJ Case Rep. 2013 Aug 28;2013:bcr2013009289. doi: 10.1136/bcr-2013-009289. BMJ Case Rep. 2013. PMID: 23986125 Free PMC article.
From this clinical observation, it is reasonable to infer that a focal, severe thiamine deficiency due to a dysfunction of thiamine metabolism could cause a selective neuronal damage in the centres that are typically hit in this disease. Injection of high doses of …
From this clinical observation, it is reasonable to infer that a focal, severe thiamine deficiency due to a dysfunction of thiamin …
Long-Term Treatment with High-Dose Thiamine in Parkinson Disease: An Open-Label Pilot Study.
Costantini A, Pala MI, Grossi E, Mondonico S, Cardelli LE, Jenner C, Proietti S, Colangeli M, Fancellu R. Costantini A, et al. J Altern Complement Med. 2015 Dec;21(12):740-7. doi: 10.1089/acm.2014.0353. Epub 2015 Oct 27. J Altern Complement Med. 2015. PMID: 26505466
OBJECTIVES: To investigate the potential clinical, restorative, and neuroprotective effects of long-term treatment with thiamine in Parkinson disease (PD). DESIGN: Observational open-label pilot study. ...Thiamine could have both restorative and neuroprotective acti …
OBJECTIVES: To investigate the potential clinical, restorative, and neuroprotective effects of long-term treatment with thiamine in P …
Can long-term thiamine treatment improve the clinical outcomes of myotonic dystrophy type 1?
Costantini A, Trevi E, Pala MI, Fancellu R. Costantini A, et al. Neural Regen Res. 2016 Sep;11(9):1487-1491. doi: 10.4103/1673-5374.191225. Neural Regen Res. 2016. PMID: 27857755 Free PMC article.
Thiamine deficiency is critical mainly in the central and peripheral nervous system, as well as in the muscular cells. ...These findings suggest that clinical outcomes are improved by long-term thiamine treatment....
Thiamine deficiency is critical mainly in the central and peripheral nervous system, as well as in the muscular cells. ...These findi …
15 results