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Clofazimine for Treatment of Cryptosporidiosis in Human Immunodeficiency Virus Infected Adults: An Experimental Medicine, Randomized, Double-blind, Placebo-controlled Phase 2a Trial.
Iroh Tam P, Arnold SLM, Barrett LK, Chen CR, Conrad TM, Douglas E, Gordon MA, Hebert D, Henrion M, Hermann D, Hollingsworth B, Houpt E, Jere KC, Lindblad R, Love MS, Makhaza L, McNamara CW, Nedi W, Nyirenda J, Operario DJ, Phulusa J, Quinnan GV, Sawyer LA, Thole H, Toto N, Winter A, Van Voorhis WC. Iroh Tam P, et al. Among authors: thole h. Clin Infect Dis. 2021 Jul 15;73(2):183-191. doi: 10.1093/cid/ciaa421. Clin Infect Dis. 2021. PMID: 32277809 Free PMC article. Clinical Trial.
Distinct clinical and immunological profiles of patients with evidence of SARS-CoV-2 infection in sub-Saharan Africa.
Morton B, Barnes KG, Anscombe C, Jere K, Matambo P, Mandolo J, Kamng'ona R, Brown C, Nyirenda J, Phiri T, Banda NP, Van Der Veer C, Mndolo KS, Mponda K, Rylance J, Phiri C, Mallewa J, Nyirenda M, Katha G, Kambiya P, Jafali J, Mwandumba HC, Gordon SB; Blantyre COVID-19 Consortium; Cornick J, Jambo KC. Morton B, et al. Nat Commun. 2021 Jun 11;12(1):3554. doi: 10.1038/s41467-021-23267-w. Nat Commun. 2021. PMID: 34117221 Free PMC article.
Respiratory cryptosporidiosis in Malawian children with diarrheal disease.
Iroh Tam PY, Chisala M, Nyangulu W, Thole H, Nyirenda J. Iroh Tam PY, et al. Among authors: thole h. PLoS Negl Trop Dis. 2021 Jul 30;15(7):e0009643. doi: 10.1371/journal.pntd.0009643. eCollection 2021 Jul. PLoS Negl Trop Dis. 2021. PMID: 34329296 Free PMC article.
A comparison of four epidemic waves of COVID-19 in Malawi; an observational cohort study.
Anscombe C, Lissauer S, Thole H, Rylance J, Dula D, Menyere M, Kutambe B, van der Veer C, Phiri T, Banda NP, Mndolo KS, Mponda K, Phiri C, Mallewa J, Nyirenda M, Katha G, Mwandumba H, Gordon SB, Jambo KC, Cornick J, Feasey N, Barnes KG, Morton B, Ashton PM; Blantyre COVID-19 Consortium. Anscombe C, et al. Among authors: thole h. BMC Infect Dis. 2023 Feb 7;23(1):79. doi: 10.1186/s12879-022-07941-y. BMC Infect Dis. 2023. PMID: 36750921 Free PMC article.
Different clinical features in Malawian outpatients presenting with COVID-19 prior to and during Omicron variant dominance: A prospective observational study.
Chibwana MG, Thole HW, Anscombe C, Ashton PM, Green E, Barnes KG, Cornick J, Turner A, Witte D, Nthala S, Thom C, Kanyandula F, Ainani A, Mtike N, Tambala H, N'goma V, Mwafulirwa D, Asima E, Morton B, Gmeiner M, Gundah Z, Kawalazira G, French N, Feasey N, Heyderman RS, Swarthout TD, Jambo KC. Chibwana MG, et al. Among authors: thole hw. PLOS Glob Public Health. 2023 Mar 8;3(3):e0001575. doi: 10.1371/journal.pgph.0001575. eCollection 2023. PLOS Glob Public Health. 2023. PMID: 36963090 Free PMC article.
Examination of ELISA against PCR for assessing treatment efficacy against Cryptosporidium in a clinical trial context.
Nyirenda JT, Henrion MYR, Nyasulu V, Msakwiza M, Nedi W, Thole H, Phulusa J, Toto N, Jere KC, Winter A, Sawyer LA, Conrad T, Hebert D, Chen C, Van Voorhis WC, Houpt ER, Iroh Tam PY, Operario DJ. Nyirenda JT, et al. Among authors: thole h. PLoS One. 2023 Sep 8;18(9):e0289929. doi: 10.1371/journal.pone.0289929. eCollection 2023. PLoS One. 2023. PMID: 37682856 Free PMC article. Clinical Trial.
Clofazimine pharmacokinetics in HIV-infected adults with diarrhea: Implications of diarrheal disease on absorption of orally administered therapeutics.
Zhang CX, Conrad TM, Hermann D, Gordon MA, Houpt E, Iroh Tam PY, Jere KC, Nedi W, Operario DJ, Phulusa J, Quinnan GV Jr, Sawyer LA, Barrett LK, Thole H, Toto N, Van Voorhis WC, Arnold SLM. Zhang CX, et al. Among authors: thole h. CPT Pharmacometrics Syst Pharmacol. 2024 Mar;13(3):410-423. doi: 10.1002/psp4.13092. Epub 2024 Jan 2. CPT Pharmacometrics Syst Pharmacol. 2024. PMID: 38164114 Free PMC article.
A comparison of four epidemic waves of COVID-19 in Malawi; an observational cohort study.
Anscombe C, Lissauer S, Thole H, Rylance J, Dula D, Menyere M, Kutambe B, van der Veer C, Phiri T, Banda NP, Mndolo KS, Mponda K, Phiri C, Mallewa J, Nyirenda M, Katha G, Mwandumba H, Gordon SB, Jambo KC, Cornick J, Feasey N, Barnes KG, Morton B, Ashton PM; Blantyre COVID-19 Consortium. Anscombe C, et al. Among authors: thole h. medRxiv [Preprint]. 2022 Jul 11:2022.02.17.22269742. doi: 10.1101/2022.02.17.22269742. medRxiv. 2022. PMID: 35860218 Free PMC article. Updated. Preprint.
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