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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1996 2
1998 2
2000 3
2001 5
2002 3
2003 2
2005 2
2006 1
2008 1
2011 4
2012 1
2013 1
2014 4
2015 2
2016 3
2017 2
2018 4
2019 4
2020 9
2021 4
2022 3
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62 results
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Page 1
Rational discovery of molecular glue degraders via scalable chemical profiling.
Mayor-Ruiz C, Bauer S, Brand M, Kozicka Z, Siklos M, Imrichova H, Kaltheuner IH, Hahn E, Seiler K, Koren A, Petzold G, Fellner M, Bock C, Müller AC, Zuber J, Geyer M, Thomä NH, Kubicek S, Winter GE. Mayor-Ruiz C, et al. Among authors: thoma nh. Nat Chem Biol. 2020 Nov;16(11):1199-1207. doi: 10.1038/s41589-020-0594-x. Epub 2020 Aug 3. Nat Chem Biol. 2020. PMID: 32747809 Free PMC article.
The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K.
Słabicki M, Kozicka Z, Petzold G, Li YD, Manojkumar M, Bunker RD, Donovan KA, Sievers QL, Koeppel J, Suchyta D, Sperling AS, Fink EC, Gasser JA, Wang LR, Corsello SM, Sellar RS, Jan M, Gillingham D, Scholl C, Fröhling S, Golub TR, Fischer ES, Thomä NH, Ebert BL. Słabicki M, et al. Among authors: thoma nh. Nature. 2020 Sep;585(7824):293-297. doi: 10.1038/s41586-020-2374-x. Epub 2020 Jun 3. Nature. 2020. PMID: 32494016 Free PMC article.
Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide.
Fischer ES, Böhm K, Lydeard JR, Yang H, Stadler MB, Cavadini S, Nagel J, Serluca F, Acker V, Lingaraju GM, Tichkule RB, Schebesta M, Forrester WC, Schirle M, Hassiepen U, Ottl J, Hild M, Beckwith RE, Harper JW, Jenkins JL, Thomä NH. Fischer ES, et al. Among authors: thoma nh. Nature. 2014 Aug 7;512(7512):49-53. doi: 10.1038/nature13527. Epub 2014 Jul 16. Nature. 2014. PMID: 25043012 Free PMC article.
Mechanisms of OCT4-SOX2 motif readout on nucleosomes.
Michael AK, Grand RS, Isbel L, Cavadini S, Kozicka Z, Kempf G, Bunker RD, Schenk AD, Graff-Meyer A, Pathare GR, Weiss J, Matsumoto S, Burger L, Schübeler D, Thomä NH. Michael AK, et al. Among authors: thoma nh. Science. 2020 Jun 26;368(6498):1460-1465. doi: 10.1126/science.abb0074. Epub 2020 Apr 23. Science. 2020. PMID: 32327602
RIF1 acts in DNA repair through phosphopeptide recognition of 53BP1.
Setiaputra D, Escribano-Díaz C, Reinert JK, Sadana P, Zong D, Callen E, Sifri C, Seebacher J, Nussenzweig A, Thomä NH, Durocher D. Setiaputra D, et al. Among authors: thoma nh. Mol Cell. 2022 Apr 7;82(7):1359-1371.e9. doi: 10.1016/j.molcel.2022.01.025. Epub 2022 Feb 24. Mol Cell. 2022. PMID: 35216668
Targeted protein degradation: from small molecules to complex organelles-a Keystone Symposia report.
Cable J, Weber-Ban E, Clausen T, Walters KJ, Sharon M, Finley DJ, Gu Y, Hanna J, Feng Y, Martens S, Simonsen A, Hansen M, Zhang H, Goodwin JM, Reggio A, Chang C, Ge L, Schulman BA, Deshaies RJ, Dikic I, Harper JW, Wertz IE, Thomä NH, Słabicki M, Frydman J, Jakob U, David DC, Bennett EJ, Bertozzi CR, Sardana R, Eapen VV, Carra S. Cable J, et al. Among authors: thoma nh. Ann N Y Acad Sci. 2022 Apr;1510(1):79-99. doi: 10.1111/nyas.14745. Epub 2022 Jan 8. Ann N Y Acad Sci. 2022. PMID: 35000205
Reading the chromatinized genome.
Michael AK, Thomä NH. Michael AK, et al. Among authors: thoma nh. Cell. 2021 Jul 8;184(14):3599-3611. doi: 10.1016/j.cell.2021.05.029. Epub 2021 Jun 18. Cell. 2021. PMID: 34146479 Free article. Review.
62 results