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359 results
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Diversity as strategy.
Thomas DA. Thomas DA. Harv Bus Rev. 2004 Sep;82(9):98-108, 138. Harv Bus Rev. 2004. PMID: 15449859
Development of an intracellular quantitative assay to measure compound binding kinetics.
Lay CS, Thomas DA, Evans JP, Campbell M, McCombe K, Phillipou AN, Gordon LJ, Jones EJ, Riching K, Mahmood M, Messenger C, Carver CE, Gatfield KM, Craggs PD. Lay CS, et al. Among authors: thomas da. Cell Chem Biol. 2021 Sep 11:S2451-9456(21)00358-5. doi: 10.1016/j.chembiol.2021.07.018. Online ahead of print. Cell Chem Biol. 2021. PMID: 34520747
Discovery of GSK251: A Highly Potent, Highly Selective, Orally Bioavailable Inhibitor of PI3Kδ with a Novel Binding Mode.
Down K, Amour A, Anderson NA, Barton N, Campos S, Cannons EP, Clissold C, Convery MA, Coward JJ, Doyle K, Duempelfeld B, Edwards CD, Goldsmith MD, Krause J, Mallett DN, McGonagle GA, Patel VK, Rowedder J, Rowland P, Sharpe A, Sriskantharajah S, Thomas DA, Thomson DW, Uddin S, Hamblin JN, Hessel EM. Down K, et al. Among authors: thomas da. J Med Chem. 2021 Sep 23;64(18):13780-13792. doi: 10.1021/acs.jmedchem.1c01102. Epub 2021 Sep 11. J Med Chem. 2021. PMID: 34510892
Acetylation of the Catalytic Lysine Inhibits Kinase Activity in PI3Kδ.
Fournier JCL, Evans JP, Zappacosta F, Thomas DA, Patel VK, White GV, Campos S, Tomkinson NCO. Fournier JCL, et al. Among authors: thomas da. ACS Chem Biol. 2021 Sep 17;16(9):1644-1653. doi: 10.1021/acschembio.1c00225. Epub 2021 Aug 16. ACS Chem Biol. 2021. PMID: 34397208
Visual Recovery of Dysthyroid Optic Neuropathy With Teprotumumab.
Lopez MJ, Herring JL, Thomas C, Bertram BA, Thomas DA. Lopez MJ, et al. Among authors: thomas da. J Neuroophthalmol. 2021 Jun 25. doi: 10.1097/WNO.0000000000001298. Online ahead of print. J Neuroophthalmol. 2021. PMID: 34173359 No abstract available.
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