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An in vitro study of alginate oligomer therapies on oral biofilms.
Roberts JL, Khan S, Emanuel C, Powell LC, Pritchard MF, Onsøyen E, Myrvold R, Thomas DW, Hill KE. Roberts JL, et al. Among authors: Thomas DW. J Dent. 2013 Oct;41(10):892-9. doi: 10.1016/j.jdent.2013.07.011. Epub 2013 Jul 30. J Dent. 2013. PMID: 23907083
Targeted disruption of the extracellular polymeric network of Pseudomonas aeruginosa biofilms by alginate oligosaccharides.
Powell LC, Pritchard MF, Ferguson EL, Powell KA, Patel SU, Rye PD, Sakellakou SM, Buurma NJ, Brilliant CD, Copping JM, Menzies GE, Lewis PD, Hill KE, Thomas DW. Powell LC, et al. Among authors: Thomas DW. NPJ Biofilms Microbiomes. 2018 Jun 29;4:13. doi: 10.1038/s41522-018-0056-3. eCollection 2018. NPJ Biofilms Microbiomes. 2018. PMID: 29977590 Free PMC article.
Alginate Oligosaccharide-Induced Modification of the lasI-lasR and rhlI-rhlR Quorum-Sensing Systems in Pseudomonas aeruginosa.
Jack AA, Khan S, Powell LC, Pritchard MF, Beck K, Sadh H, Sutton L, Cavaliere A, Florance H, Rye PD, Thomas DW, Hill KE. Jack AA, et al. Among authors: Thomas DW. Antimicrob Agents Chemother. 2018 Apr 26;62(5):e02318-17. doi: 10.1128/AAC.02318-17. Print 2018 May. Antimicrob Agents Chemother. 2018. PMID: 29463534 Free PMC article.
The antimicrobial effects of the alginate oligomer OligoG CF-5/20 are independent of direct bacterial cell membrane disruption.
Pritchard MF, Powell LC, Khan S, Griffiths PC, Mansour OT, Schweins R, Beck K, Buurma NJ, Dempsey CE, Wright CJ, Rye PD, Hill KE, Thomas DW, Ferguson EL. Pritchard MF, et al. Among authors: Thomas DW. Sci Rep. 2017 Mar 31;7:44731. doi: 10.1038/srep44731. Sci Rep. 2017. PMID: 28361894 Free PMC article.
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