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5,335 results
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An encore for ribosome biogenesis in the control of cell proliferation.
Thomas G. Thomas G. Nat Cell Biol. 2000 May;2(5):E71-2. doi: 10.1038/35010581. Nat Cell Biol. 2000. PMID: 10806485 Review.
The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation.
Beuvink I, Boulay A, Fumagalli S, Zilbermann F, Ruetz S, O'Reilly T, Natt F, Hall J, Lane HA, Thomas G. Beuvink I, et al. Among authors: thomas g. Cell. 2005 Mar 25;120(6):747-59. doi: 10.1016/j.cell.2004.12.040. Cell. 2005. PMID: 15797377
S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway.
Pende M, Um SH, Mieulet V, Sticker M, Goss VL, Mestan J, Mueller M, Fumagalli S, Kozma SC, Thomas G. Pende M, et al. Among authors: thomas g. Mol Cell Biol. 2004 Apr;24(8):3112-24. doi: 10.1128/mcb.24.8.3112-3124.2004. Mol Cell Biol. 2004. PMID: 15060135 Free PMC article.
Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2.
Garami A, Zwartkruis FJ, Nobukuni T, Joaquin M, Roccio M, Stocker H, Kozma SC, Hafen E, Bos JL, Thomas G. Garami A, et al. Among authors: thomas g. Mol Cell. 2003 Jun;11(6):1457-66. doi: 10.1016/s1097-2765(03)00220-x. Mol Cell. 2003. PMID: 12820960
Rheb is an essential regulator of S6K in controlling cell growth in Drosophila.
Stocker H, Radimerski T, Schindelholz B, Wittwer F, Belawat P, Daram P, Breuer S, Thomas G, Hafen E. Stocker H, et al. Among authors: thomas g. Nat Cell Biol. 2003 Jun;5(6):559-65. doi: 10.1038/ncb995. Nat Cell Biol. 2003. PMID: 12766775
The S6 kinase signaling pathway in the control of development and growth.
Thomas G. Thomas G. Biol Res. 2002;35(2):305-13. doi: 10.4067/s0716-97602002000200022. Biol Res. 2002. PMID: 12415748 Review.
Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling.
Radimerski T, Montagne J, Hemmings-Mieszczak M, Thomas G. Radimerski T, et al. Among authors: thomas g. Genes Dev. 2002 Oct 15;16(20):2627-32. doi: 10.1101/gad.239102. Genes Dev. 2002. PMID: 12381661 Free PMC article.
Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K.
Kozma SC, Thomas G. Kozma SC, et al. Among authors: thomas g. Bioessays. 2002 Jan;24(1):65-71. doi: 10.1002/bies.10031. Bioessays. 2002. PMID: 11782951 Review.
dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1.
Radimerski T, Montagne J, Rintelen F, Stocker H, van der Kaay J, Downes CP, Hafen E, Thomas G. Radimerski T, et al. Among authors: thomas g. Nat Cell Biol. 2002 Mar;4(3):251-5. doi: 10.1038/ncb763. Nat Cell Biol. 2002. PMID: 11862217
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity.
Um SH, Frigerio F, Watanabe M, Picard F, Joaquin M, Sticker M, Fumagalli S, Allegrini PR, Kozma SC, Auwerx J, Thomas G. Um SH, et al. Among authors: thomas g. Nature. 2004 Sep 9;431(7005):200-5. doi: 10.1038/nature02866. Epub 2004 Aug 11. Nature. 2004. PMID: 15306821
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