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ARF and PITP restore GTP gamma S-stimulated protein secretion from cytosol-depleted HL60 cells by promoting PIP2 synthesis.
Fensome A, Cunningham E, Prosser S, Tan SK, Swigart P, Thomas G, Hsuan J, Cockcroft S. Fensome A, et al. Curr Biol. 1996 Jun 1;6(6):730-8. doi: 10.1016/s0960-9822(09)00454-0. Curr Biol. 1996. PMID: 8793299
Requirement for phosphatidylinositol transfer protein in epidermal growth factor signaling.
Kauffmann-Zeh A, Thomas GM, Ball A, Prosser S, Cunningham E, Cockcroft S, Hsuan JJ. Kauffmann-Zeh A, et al. Science. 1995 May 26;268(5214):1188-90. doi: 10.1126/science.7761838. Science. 1995. PMID: 7761838
Identification of a novel cytosolic poly-phosphoinositide-specific phospholipase C (PLC-86) as the major G-protein-regulated enzyme.
Thomas GM, Geny B, Cockcroft S. Thomas GM, et al. EMBO J. 1991 Sep;10(9):2507-12. EMBO J. 1991. PMID: 1651229 Free PMC article.
In this study we demonstrate that the PLC activity from rat brain cytosol can be regulated in a G-protein-dependent manner in a reconstituted system using pre-permeabilized HL60 cells. We identify two enzymes, PLC-beta and a novel 86 kDa enzyme (designated PLC-epsilon) as …
In this study we demonstrate that the PLC activity from rat brain cytosol can be regulated in a G-protein-dependent manner in a recon …
Phospholipase D: a downstream effector of ARF in granulocytes.
Cockcroft S, Thomas GM, Fensome A, Geny B, Cunningham E, Gout I, Hiles I, Totty NF, Truong O, Hsuan JJ. Cockcroft S, et al. Science. 1994 Jan 28;263(5146):523-6. doi: 10.1126/science.8290961. Science. 1994. PMID: 8290961
Interaction of furin in immature secretory granules from neuroendocrine cells with the AP-1 adaptor complex is modulated by casein kinase II phosphorylation.
Dittié AS, Thomas L, Thomas G, Tooze SA. Dittié AS, et al. EMBO J. 1997 Aug 15;16(16):4859-70. doi: 10.1093/emboj/16.16.4859. EMBO J. 1997. PMID: 9305628 Free PMC article.
An essential role for phosphatidylinositol transfer protein in phospholipase C-mediated inositol lipid signaling.
Thomas GM, Cunningham E, Fensome A, Ball A, Totty NF, Truong O, Hsuan JJ, Cockcroft S. Thomas GM, et al. Cell. 1993 Sep 10;74(5):919-28. doi: 10.1016/0092-8674(93)90471-2. Cell. 1993. PMID: 8374957
Transmembrane signaling by the phospholipase C-beta (PLC-beta) pathway is known to require at least three components: the receptor, the G protein, and the PLC. Recent studies have indicated that if the cytosol is allowed to leak out of HL60 cells, then G protein-sti …
Transmembrane signaling by the phospholipase C-beta (PLC-beta) pathway is known to require at least three components: the receptor, the G
Regulation of cytosolic phosphoinositide-phospholipase C by G-protein, Gp.
Cockcroft S, Geny B, Thomas GM. Cockcroft S, et al. Biochem Soc Trans. 1991 Apr;19(2):299-302. doi: 10.1042/bst0190299. Biochem Soc Trans. 1991. PMID: 1653732 Review. No abstract available.
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