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Regulation of p70s6k/p85s6k and its role in the cell cycle.
Pearson RB, Thomas G. Pearson RB, et al. Prog Cell Cycle Res. 1995;1:21-32. doi: 10.1007/978-1-4615-1809-9_3. Prog Cell Cycle Res. 1995. PMID: 9552351 Review.
The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation.
Beuvink I, Boulay A, Fumagalli S, Zilbermann F, Ruetz S, O'Reilly T, Natt F, Hall J, Lane HA, Thomas G. Beuvink I, et al. Cell. 2005 Mar 25;120(6):747-59. doi: 10.1016/j.cell.2004.12.040. Cell. 2005. PMID: 15797377
Phytohormones participate in an S6 kinase signal transduction pathway in Arabidopsis.
Turck F, Zilbermann F, Kozma SC, Thomas G, Nagy F. Turck F, et al. Plant Physiol. 2004 Apr;134(4):1527-35. doi: 10.1104/pp.103.035873. Epub 2004 Apr 2. Plant Physiol. 2004. PMID: 15064379 Free PMC article.
S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway.
Pende M, Um SH, Mieulet V, Sticker M, Goss VL, Mestan J, Mueller M, Fumagalli S, Kozma SC, Thomas G. Pende M, et al. Mol Cell Biol. 2004 Apr;24(8):3112-24. doi: 10.1128/mcb.24.8.3112-3124.2004. Mol Cell Biol. 2004. PMID: 15060135 Free PMC article.
Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2.
Garami A, Zwartkruis FJ, Nobukuni T, Joaquin M, Roccio M, Stocker H, Kozma SC, Hafen E, Bos JL, Thomas G. Garami A, et al. Mol Cell. 2003 Jun;11(6):1457-66. doi: 10.1016/s1097-2765(03)00220-x. Mol Cell. 2003. PMID: 12820960
Rheb is an essential regulator of S6K in controlling cell growth in Drosophila.
Stocker H, Radimerski T, Schindelholz B, Wittwer F, Belawat P, Daram P, Breuer S, Thomas G, Hafen E. Stocker H, et al. Nat Cell Biol. 2003 Jun;5(6):559-65. doi: 10.1038/ncb995. Nat Cell Biol. 2003. PMID: 12766775
The S6 kinase signaling pathway in the control of development and growth.
Thomas G. Thomas G. Biol Res. 2002;35(2):305-13. doi: 10.4067/s0716-97602002000200022. Biol Res. 2002. PMID: 12415748 Review.
In parallel, a great deal of information has accumulated concerning the identification of the signaling pathway and the regulatory phosphorylation sites involved in controlling S6K activation (Dufner and Thomas, 1999). ...Use of the immunosuppressant rapamycin, a bacterial …
In parallel, a great deal of information has accumulated concerning the identification of the signaling pathway and the regulatory phosphory …
dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1.
Radimerski T, Montagne J, Rintelen F, Stocker H, van der Kaay J, Downes CP, Hafen E, Thomas G. Radimerski T, et al. Nat Cell Biol. 2002 Mar;4(3):251-5. doi: 10.1038/ncb763. Nat Cell Biol. 2002. PMID: 11862217
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