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Introduction of homologous DNA sequences into mammalian cells induces mutations in the cognate gene.
Thomas KR, Capecchi MR. Thomas KR, et al. Nature. 1986 Nov 6-12;324(6092):34-8. doi: 10.1038/324034a0. Nature. 1986. PMID: 3785372
Maintenance of functional equivalence during paralogous Hox gene evolution.
Greer JM, Puetz J, Thomas KR, Capecchi MR. Greer JM, et al. Among authors: thomas kr. Nature. 2000 Feb 10;403(6770):661-5. doi: 10.1038/35001077. Nature. 2000. PMID: 10688203
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes.
Mansour SL, Thomas KR, Capecchi MR. Mansour SL, et al. Among authors: thomas kr. Nature. 1988 Nov 24;336(6197):348-52. doi: 10.1038/336348a0. Nature. 1988. PMID: 3194019
Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development.
Thomas KR, Capecchi MR. Thomas KR, et al. Nature. 1990 Aug 30;346(6287):847-50. doi: 10.1038/346847a0. Nature. 1990. PMID: 2202907
Introduction of a lacZ reporter gene into the mouse int-2 locus by homologous recombination.
Mansour SL, Thomas KR, Deng CX, Capecchi MR. Mansour SL, et al. Among authors: thomas kr. Proc Natl Acad Sci U S A. 1990 Oct;87(19):7688-92. doi: 10.1073/pnas.87.19.7688. Proc Natl Acad Sci U S A. 1990. PMID: 2120706 Free PMC article.
Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells.
Thomas KR, Capecchi MR. Thomas KR, et al. Cell. 1987 Nov 6;51(3):503-12. doi: 10.1016/0092-8674(87)90646-5. Cell. 1987. PMID: 2822260
Interleukin receptor activates a MYD88-ARNO-ARF6 cascade to disrupt vascular stability.
Zhu W, London NR, Gibson CC, Davis CT, Tong Z, Sorensen LK, Shi DS, Guo J, Smith MC, Grossmann AH, Thomas KR, Li DY. Zhu W, et al. Among authors: thomas kr. Nature. 2012 Dec 13;492(7428):252-5. doi: 10.1038/nature11603. Epub 2012 Nov 11. Nature. 2012. PMID: 23143332 Free PMC article.
High-fidelity gene targeting in embryonic stem cells by using sequence replacement vectors.
Thomas KR, Deng C, Capecchi MR. Thomas KR, et al. Mol Cell Biol. 1992 Jul;12(7):2919-23. doi: 10.1128/mcb.12.7.2919. Mol Cell Biol. 1992. PMID: 1620105 Free PMC article.
Location of crossovers during gene targeting with insertion and replacement vectors.
Deng C, Thomas KR, Capecchi MR. Deng C, et al. Among authors: thomas kr. Mol Cell Biol. 1993 Apr;13(4):2134-40. doi: 10.1128/mcb.13.4.2134. Mol Cell Biol. 1993. PMID: 8455602 Free PMC article.
Slit2-Robo4 signalling promotes vascular stability by blocking Arf6 activity.
Jones CA, Nishiya N, London NR, Zhu W, Sorensen LK, Chan AC, Lim CJ, Chen H, Zhang Q, Schultz PG, Hayallah AM, Thomas KR, Famulok M, Zhang K, Ginsberg MH, Li DY. Jones CA, et al. Among authors: thomas kr. Nat Cell Biol. 2009 Nov;11(11):1325-31. doi: 10.1038/ncb1976. Epub 2009 Oct 18. Nat Cell Biol. 2009. PMID: 19855388 Free PMC article.
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