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Page 1
CFTR modulator theratyping: Current status, gaps and future directions.
Clancy JP, Cotton CU, Donaldson SH, Solomon GM, VanDevanter DR, Boyle MP, Gentzsch M, Nick JA, Illek B, Wallenburg JC, Sorscher EJ, Amaral MD, Beekman JM, Naren AP, Bridges RJ, Thomas PJ, Cutting G, Rowe S, Durmowicz AG, Mense M, Boeck KD, Skach W, Penland C, Joseloff E, Bihler H, Mahoney J, Borowitz D, Tuggle KL. Clancy JP, et al. Among authors: thomas pj. J Cyst Fibros. 2019 Jan;18(1):22-34. doi: 10.1016/j.jcf.2018.05.004. Epub 2018 Jun 20. J Cyst Fibros. 2019. PMID: 29934203 Free PMC article. Review.
Cystic fibrosis: recent structural insights.
Dorwart M, Thibodeau P, Thomas P. Dorwart M, et al. J Cyst Fibros. 2004 Aug;3 Suppl 2:91-4. doi: 10.1016/j.jcf.2004.05.020. J Cyst Fibros. 2004. PMID: 15463935 Free article. Review.
Side chain and backbone contributions of Phe508 to CFTR folding.
Thibodeau PH, Brautigam CA, Machius M, Thomas PJ. Thibodeau PH, et al. Among authors: thomas pj. Nat Struct Mol Biol. 2005 Jan;12(1):10-6. doi: 10.1038/nsmb881. Epub 2004 Dec 26. Nat Struct Mol Biol. 2005. PMID: 15619636 Free PMC article.
Regulatory interaction between CFTR and the SLC26 transporters.
Shcheynikov N, Ko SB, Zeng W, Choi JY, Dorwart MR, Thomas PJ, Muallem S. Shcheynikov N, et al. Among authors: thomas pj. Novartis Found Symp. 2006;273:177-86; discussion 186-92, 261-4. Novartis Found Symp. 2006. PMID: 17120768
Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis.
Hutt DM, Herman D, Rodrigues AP, Noel S, Pilewski JM, Matteson J, Hoch B, Kellner W, Kelly JW, Schmidt A, Thomas PJ, Matsumura Y, Skach WR, Gentzsch M, Riordan JR, Sorscher EJ, Okiyoneda T, Yates JR 3rd, Lukacs GL, Frizzell RA, Manning G, Gottesfeld JM, Balch WE. Hutt DM, et al. Among authors: thomas pj. Nat Chem Biol. 2010 Jan;6(1):25-33. doi: 10.1038/nchembio.275. Epub 2009 Dec 6. Nat Chem Biol. 2010. PMID: 19966789 Free PMC article.
Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening.
Kalid O, Mense M, Fischman S, Shitrit A, Bihler H, Ben-Zeev E, Schutz N, Pedemonte N, Thomas PJ, Bridges RJ, Wetmore DR, Marantz Y, Senderowitz H. Kalid O, et al. Among authors: thomas pj. J Comput Aided Mol Des. 2010 Dec;24(12):971-91. doi: 10.1007/s10822-010-9390-0. Epub 2010 Oct 26. J Comput Aided Mol Des. 2010. PMID: 20976528 Free PMC article.
503 results