Thompson AJ - Search Results

1

Defining the roles of Asn-128, Glu-129 and Phe-130 in loop A of the 5-HT3 receptor.

Sullivan NL, Thompson AJ, Price KL, Lummis SC. Sullivan NL, et al. Among authors: thompson aj. Mol Membr Biol. 2006 Sep-Oct;23(5):442-51. doi: 10.1080/09687860600831539. Mol Membr Biol. 2006. PMID: 17060161 Free PMC article.

2

A single ring of charged amino acids at one end of the pore can control ion selectivity in the 5-HT3 receptor.

Thompson AJ, Lummis SC. Thompson AJ, et al. Br J Pharmacol. 2003 Sep;140(2):359-65. doi: 10.1038/sj.bjp.0705424. Epub 2003 Aug 11. Br J Pharmacol. 2003. PMID: 12970096 Free PMC article.

3

Locating an antagonist in the 5-HT3 receptor binding site using modeling and radioligand binding.

Thompson AJ, Price KL, Reeves DC, Chan SL, Chau PL, Lummis SC. Thompson AJ, et al. J Biol Chem. 2005 May 27;280(21):20476-82. doi: 10.1074/jbc.M413610200. Epub 2005 Mar 21. J Biol Chem. 2005. PMID: 15781467 Free article.

4

Mutagenesis and molecular modeling reveal the importance of the 5-HT3 receptor F-loop.

Thompson AJ, Padgett CL, Lummis SC. Thompson AJ, et al. J Biol Chem. 2006 Jun 16;281(24):16576-82. doi: 10.1074/jbc.M601265200. Epub 2006 Apr 4. J Biol Chem. 2006. PMID: 16595668 Free article.

5

The 5-HT3 receptor as a therapeutic target.

Thompson AJ, Lummis SC. Thompson AJ, et al. Expert Opin Ther Targets. 2007 Apr;11(4):527-40. doi: 10.1517/14728222.11.4.527. Expert Opin Ther Targets. 2007. PMID: 17373882 Free PMC article. Review.

6

Characterization of 5-HT3 receptor mutations identified in schizophrenic patients.

Thompson AJ, Sullivan NL, Lummis SC. Thompson AJ, et al. J Mol Neurosci. 2006;30(3):273-81. doi: 10.1385/JMN:30:3:273. J Mol Neurosci. 2006. PMID: 17401153 Free PMC article.

7

A hydrogen bond in loop A is critical for the binding and function of the 5-HT3 receptor.

Price KL, Bower KS, Thompson AJ, Lester HA, Dougherty DA, Lummis SC. Price KL, et al. Among authors: thompson aj. Biochemistry. 2008 Jun 17;47(24):6370-7. doi: 10.1021/bi800222n. Epub 2008 May 22. Biochemistry. 2008. PMID: 18498149 Free PMC article.

8

Calcium modulation of 5-HT3 receptor binding and function.

Thompson AJ, Lummis SC. Thompson AJ, et al. Neuropharmacology. 2009 Jan;56(1):285-91. doi: 10.1016/j.neuropharm.2008.07.009. Epub 2008 Jul 16. Neuropharmacology. 2009. PMID: 18675830 Free PMC article.

9

The structural basis of function in Cys-loop receptors.

Thompson AJ, Lester HA, Lummis SC. Thompson AJ, et al. Q Rev Biophys. 2010 Nov;43(4):449-99. doi: 10.1017/S0033583510000168. Epub 2010 Sep 20. Q Rev Biophys. 2010. PMID: 20849671 Review.

10

Structure-activity relationships of quinoxaline-based 5-HT3A and 5-HT3AB receptor-selective ligands.

Thompson AJ, Verheij MH, van Muijlwijk-Koezen JE, Lummis SC, Leurs R, de Esch IJ. Thompson AJ, et al. ChemMedChem. 2013 Jun;8(6):946-55. doi: 10.1002/cmdc.201300032. Epub 2013 May 2. ChemMedChem. 2013. PMID: 23640722 Free PMC article.

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