Thompson PE - Search Results

1

Thiophene inhibitors of PDE4: crystal structures show a second binding mode at the catalytic domain of PDE4D2.

Nankervis JL, Feil SC, Hancock NC, Zheng Z, Ng HL, Morton CJ, Holien JK, Ho PW, Frazzetto MM, Jennings IG, Manallack DT, Martin TJ, Thompson PE, Parker MW. Nankervis JL, et al. Among authors: thompson pe. Bioorg Med Chem Lett. 2011 Dec 1;21(23):7089-93. doi: 10.1016/j.bmcl.2011.09.109. Epub 2011 Oct 5. Bioorg Med Chem Lett. 2011. PMID: 22030030

2

PDE2 inhibition by the PI3 kinase inhibitor LY294002 and analogues.

Abbott BM, Thompson PE. Abbott BM, et al. Among authors: thompson pe. Bioorg Med Chem Lett. 2004 Jun 7;14(11):2847-51. doi: 10.1016/j.bmcl.2004.03.043. Bioorg Med Chem Lett. 2004. PMID: 15125945

3

Identification of a unique filamin A binding region within the cytoplasmic domain of glycoprotein Ibalpha.

Cranmer SL, Pikovski I, Mangin P, Thompson PE, Domagala T, Frazzetto M, Salem HH, Jackson SP. Cranmer SL, et al. Among authors: thompson pe. Biochem J. 2005 May 1;387(Pt 3):849-58. doi: 10.1042/BJ20041836. Biochem J. 2005. PMID: 15574123 Free PMC article.

4

The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases.

Manallack DT, Hughes RA, Thompson PE. Manallack DT, et al. Among authors: thompson pe. J Med Chem. 2005 May 19;48(10):3449-62. doi: 10.1021/jm040217u. J Med Chem. 2005. PMID: 15887951 Review. No abstract available.

5

Analysis of anti-PDE3 activity of 2-morpholinochromone derivatives reveals multiple mechanisms of anti-platelet activity.

Abbott BM, Thompson PE. Abbott BM, et al. Among authors: thompson pe. Bioorg Med Chem Lett. 2006 Feb 15;16(4):969-73. doi: 10.1016/j.bmcl.2005.10.092. Epub 2005 Nov 15. Bioorg Med Chem Lett. 2006. PMID: 16290931

6

Re-discovering PDE3 inhibitors--new opportunities for a long neglected target.

Thompson PE, Manganiello V, Degerman E. Thompson PE, et al. Curr Top Med Chem. 2007;7(4):421-36. doi: 10.2174/156802607779941224. Curr Top Med Chem. 2007. PMID: 17305583 Review.

7

Dissecting isoform selectivity of PI3K inhibitors: the role of non-conserved residues in the catalytic pocket.

Frazzetto M, Suphioglu C, Zhu J, Schmidt-Kittler O, Jennings IG, Cranmer SL, Jackson SP, Kinzler KW, Vogelstein B, Thompson PE. Frazzetto M, et al. Among authors: thompson pe. Biochem J. 2008 Sep 15;414(3):383-90. doi: 10.1042/BJ20080512. Biochem J. 2008. PMID: 18489260 Free PMC article.

8

Development of cognitive enhancers based on inhibition of insulin-regulated aminopeptidase.

Chai SY, Yeatman HR, Parker MW, Ascher DB, Thompson PE, Mulvey HT, Albiston AL. Chai SY, et al. Among authors: thompson pe. BMC Neurosci. 2008 Dec 3;9 Suppl 2(Suppl 2):S14. doi: 10.1186/1471-2202-9-S2-S14. BMC Neurosci. 2008. PMID: 19090987 Free PMC article. Review.

9

The structure of the bacterial oxidoreductase enzyme DsbA in complex with a peptide reveals a basis for substrate specificity in the catalytic cycle of DsbA enzymes.

Paxman JJ, Borg NA, Horne J, Thompson PE, Chin Y, Sharma P, Simpson JS, Wielens J, Piek S, Kahler CM, Sakellaris H, Pearce M, Bottomley SP, Rossjohn J, Scanlon MJ. Paxman JJ, et al. Among authors: thompson pe. J Biol Chem. 2009 Jun 26;284(26):17835-45. doi: 10.1074/jbc.M109.011502. Epub 2009 Apr 22. J Biol Chem. 2009. PMID: 19389711 Free PMC article.

10

Inflammatory twins from PI3K gang brought to justice?

Thompson PE, Jennings IG, Pinson JA. Thompson PE, et al. Chem Biol. 2010 Feb 26;17(2):101-2. doi: 10.1016/j.chembiol.2010.02.001. Chem Biol. 2010. PMID: 20189098

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