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The structural basis for substrate specificity in DNA topoisomerase IV.
Corbett KD, Schoeffler AJ, Thomsen ND, Berger JM. Corbett KD, et al. Among authors: thomsen nd. J Mol Biol. 2005 Aug 19;351(3):545-61. doi: 10.1016/j.jmb.2005.06.029. J Mol Biol. 2005. PMID: 16023670
A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP6 in mRNA export.
Montpetit B, Thomsen ND, Helmke KJ, Seeliger MA, Berger JM, Weis K. Montpetit B, et al. Among authors: thomsen nd. Nature. 2011 Apr 14;472(7342):238-42. doi: 10.1038/nature09862. Epub 2011 Mar 27. Nature. 2011. PMID: 21441902 Free PMC article.
Allosteric activation mechanism of the Mycobacterium tuberculosis receptor Ser/Thr protein kinase, PknB.
Lombana TN, Echols N, Good MC, Thomsen ND, Ng HL, Greenstein AE, Falick AM, King DS, Alber T. Lombana TN, et al. Among authors: thomsen nd. Structure. 2010 Dec 8;18(12):1667-77. doi: 10.1016/j.str.2010.09.019. Structure. 2010. PMID: 21134645 Free PMC article.
Running in reverse: the structural basis for translocation polarity in hexameric helicases.
Thomsen ND, Berger JM. Thomsen ND, et al. Cell. 2009 Oct 30;139(3):523-34. doi: 10.1016/j.cell.2009.08.043. Cell. 2009. PMID: 19879839 Free PMC article.
Structural frameworks for considering microbial protein- and nucleic acid-dependent motor ATPases.
Thomsen ND, Berger JM. Thomsen ND, et al. Mol Microbiol. 2008 Sep;69(5):1071-90. doi: 10.1111/j.1365-2958.2008.06364.x. Epub 2008 Jul 21. Mol Microbiol. 2008. PMID: 18647240 Free PMC article. Review.
Molecular mechanisms of substrate-controlled ring dynamics and substepping in a nucleic acid-dependent hexameric motor.
Thomsen ND, Lawson MR, Witkowsky LB, Qu S, Berger JM. Thomsen ND, et al. Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):E7691-E7700. doi: 10.1073/pnas.1616745113. Epub 2016 Nov 16. Proc Natl Acad Sci U S A. 2016. PMID: 27856760 Free PMC article.
Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation.
Thomsen ND, Koerber JT, Wells JA. Thomsen ND, et al. Proc Natl Acad Sci U S A. 2013 May 21;110(21):8477-82. doi: 10.1073/pnas.1306759110. Epub 2013 May 6. Proc Natl Acad Sci U S A. 2013. PMID: 23650375 Free PMC article.
Crystallization and X-ray structure determination of an RNA-dependent hexameric helicase.
Thomsen ND, Berger JM. Thomsen ND, et al. Methods Enzymol. 2012;511:171-90. doi: 10.1016/B978-0-12-396546-2.00008-5. Methods Enzymol. 2012. PMID: 22713320 Free PMC article.
Nature-inspired design of motif-specific antibody scaffolds.
Koerber JT, Thomsen ND, Hannigan BT, Degrado WF, Wells JA. Koerber JT, et al. Among authors: thomsen nd. Nat Biotechnol. 2013 Oct;31(10):916-21. doi: 10.1038/nbt.2672. Epub 2013 Aug 18. Nat Biotechnol. 2013. PMID: 23955275 Free PMC article.
A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1.
Rettenmaier TJ, Sadowsky JD, Thomsen ND, Chen SC, Doak AK, Arkin MR, Wells JA. Rettenmaier TJ, et al. Among authors: thomsen nd. Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18590-5. doi: 10.1073/pnas.1415365112. Epub 2014 Dec 17. Proc Natl Acad Sci U S A. 2014. PMID: 25518860 Free PMC article.
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