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Expression of pleiotrophin in the prostate is androgen regulated and it functions as an autocrine regulator of mesenchyme and cancer associated fibroblasts and as a paracrine regulator of epithelia.
Orr B, Vanpoucke G, Grace OC, Smith L, Anderson RA, Riddick AC, Franco OE, Hayward SW, Thomson AA. Orr B, et al. Among authors: thomson aa. Prostate. 2011 Feb 15;71(3):305-17. doi: 10.1002/pros.21244. Epub 2010 Sep 1. Prostate. 2011. PMID: 20812209 Free PMC article.
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